Postdoctoral training
Three-dimensional cell culture assays.
Status:
Graduated from 2013 to 2017.
About me
Group leader of Translational Disease Models and Neurodegeneration Group of the Laboratory of Experimental Medicine at IMTM. My research focuses on misfolding, aggregation and prion-like spreading of tau in Alzheimer's disease and α-synuclein in Parkinson's disease and ways to target them and the use of physiologically relevant cellular models for disease modelling and drug discovery.
Selected publications
- ANNADURAI, N., L. MALINA, J. MALOHLAVA, M. HAJDÚCH and V. DAS. Tau R2 and R3 are essential regions for tau aggregation, seeding and propagation. Biochimie. 2022, 200 79-86. ISSN: 0300-9084.
- ANNADURAI, N., L. MALINA, M. SALMONA, L. DIOMEDE, A. BASTONE, A. CAGNOTTO, M. ROMEO, M. SREJBER, K. BERKA, M. OTYEPKA, M. HAJDÚCH and V. DAS. Antitumour drugs targeting tau R3 VQIVYK and Cys322 prevent seeding of endogenous tau aggregates by exogenous seeds. FEBS Journal. 2022, 289:1929-1949.
- ANNADURAI, N., J. DE SANCTIS, M. HAJDÚCH and V. DAS. Tau secretion and propagation: perspectives for potential preventive interventions in Alzheimer's disease and other tauopathies. Experimental Neurology. 2021, 343:113756.
- AGRAWAL, K., V. DAS, N. KUDLOVÁ, J. GURSKÝ, P. DŽUBÁK and M. HAJDÚCH. Differential regulation of methylation-regulating enzymes by senescent stromal cells drives colorectal cancer cell response to DNA epi-drug decitabine. Stem Cells International. 2018:6013728.
- DAS, V., F. BRUZZESE, P. KONEČNÝ, F. IANNELLI, A. BUDILLON and M. HAJDÚCH. Pathophysiologically relevant in vitro tumor models for screening of anticancer compounds. Drug Discovery Today. 2015, 20:848.
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