Das Viswanath M.Sc., Ph.D.

Journals

ALLADI, C., I. KOZLOV, P. SKOUPILOVÁ, L. MALINA, S. ROY, V. DAS
Structural and functional insights into the selective inhibition of mutant tau aggregation by purpurin and oleocanthal in frontotemporal dementia. Protein Science. 2025, 34(9), e70240, ISSN: 0961-8368, PMID: 40862394,  PDF.
DAS, V., S. MODARRES MOUSAVI, N. ANNADURAI, S. SUKUR, F. MEHRNEJAD, M. MORADI, L. MALINA, M. KOLARIKOVA, V. RANC, I. FRYDRYCH, R. KOURIL, S. HOSSEINKHANI, M. HAJDÚCH, M. NIKKHAH
Hydrophobic residues in the α-synuclein NAC domain drive seed-competent fibril formation and are targeted by peptide inhibitors. Federation of European Biochemical Societies. 2025, ISSN: 1742-464X, PMID: 40819250,  PDF.
DAS, V., L. DIOMEDE, L. MALINA, M. MOSCONI, N. ANNADURAI
Intrinsic aggregation and propagation of unmodified tau peptides: R2R3 as a minimal model system. Biophysical Journal. 2025, ISSN: 0006-3495 , PMID: 40515399,

Books & book chapters

DAS, V.
Multiparametric analysis of spheroid integrity by brightfield high-content microscopy , 1.vyd., Olomouc, Palacky University, 2021, 24, 177-182, Dedication: LO1304, ISBN: 978-80-244-6049-9,
DAS, V.
Cell lines and cell culture conditions - 3D cultures , 1.vyd., Olomouc, Palacky University, 2021, 2, 15, Dedication: LO1304, ISBN: 978-80-244-6049-9,
ANNADURAI, N., V. DAS
A combination of kinetic fluorometric assay and microscopy for the screening of potential anti-tau aggregating agents, 1.vyd., Olomouc, Palacky University, 2021, 41, 317-324, Dedication: LO1304, ISBN: 978-80-244-6049-9,

Doctoral mentorship

Annadurai Narendran M.Sc., Ph.D.

Identification and Characterisation of Tau minimal regions as Potential Pharmacological Targets against Tau Spreading in Tauopathies

Stav: Absolvoval od 2015 do 2023.
Kozlov Ihor

Role of axonal transport and pathology in neurodegeneration

Stav: Probíhající od 2023.
Varečka Alexander

Dysfunction of mitochondria and microglia in tauopathies: effects of pathogenic TAU strains

Stav: Probíhající od 2025.

Master mentorship

Bechná Eliška

3D spheroids cultures of tumor cell lines for drug discovery studies

Stav: Absolvoval od 2022 do 2025.
Pavlíková Martina

Specific pharmacological modulators of tau aggregation and spreading for Alzheimer's disease preclinical studies.

Stav: Absolvoval od 2022 do 2024.
Skoupilová Patricie

Examination of mutations in tau on the activity of small molecules against prion-like tau formation in tauopathies

Stav: Absolvoval od 2023 do 2025.

Bachelor mentorship

Chudáčková Alica

Investigating the biochemical and structural alterations in tau mutants caused by VQIVYK-targeting tau inhibitors

Stav: Absolvoval od 2023 do 2025.
Vrablíková Barbora

Cytotoxicity of microtubule-stabilizing drug laulimalide in hypoxic human colorectal and cervical cancer cells

Stav: Absolvoval od 2018 do 2020.

Open positions

Projekt: The role of tumor hypoxia in the emergence of acquired resistance to drugs aimed at microtubules
Vedoucí: Das Viswanath M.Sc., Ph.D.
K dispozici: 1
Určeno pro: Doktorské studium
Souhrn: 1 place in full-time study
Projekt: Research and development of agents for cancer, neurodegenerative and infectious diseases
Vedoucí: De Sanctis Juan Bautista Ph.D., Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D., Urban Milan Ph.D., Das Viswanath M.Sc., Ph.D.
K dispozici: 5
Určeno pro: Doktorské studium
Projekt: Role of axonal transport and pathology in neurodegeneration
Vedoucí: Das Viswanath M.Sc., Ph.D.
K dispozici: 2
Určeno pro: Doktorské studium
Projekt: Systems approaches to understanding aging and neurodegeneration
Vedoucí: Das Viswanath M.Sc., Ph.D.
K dispozici: 2
Určeno pro: Doktorské studium
Projekt: Mitochondrial and microglial dysfunction in tauopathies: effects of pathogenic TAU strains
Vedoucí: Das Viswanath M.Sc., Ph.D.
K dispozici: 1
Určeno pro: Doktorské studium
Souhrn: 1 full-time position
Projekt: Investigating Effects of Aggregates of Intrinsically Disordered Proteins on Microglia: Implication for Neurodegenerative Diseases
Vedoucí: Das Viswanath M.Sc., Ph.D.
K dispozici: 1
Určeno pro: Magisterské studium
Souhrn: -
Projekt: Biochemical and cellular analysis of amyloid staining agents in models of tauopathies and synucleopathies
Vedoucí: Das Viswanath M.Sc., Ph.D.
K dispozici: 1
Určeno pro: Magisterské studium
Souhrn: -
Projekt: Generation of 3D human neuronal cultures: application to modeling CNS diseases
Vedoucí: Das Viswanath M.Sc., Ph.D.
K dispozici: 1
Určeno pro: Magisterské studium
Souhrn: -
Projekt: Efficacy of Bruton Tyrosine Kinase Inhibitors Against Neuroinflammation in Neurodegenerative Diseases
Vedoucí: Das Viswanath M.Sc., Ph.D.
K dispozici: 1
Určeno pro: Magisterské studium
Souhrn: -