Frydrych Ivo Ph.D.

Journals

FRYDRYCH, I., B. CHROMA, L. SLAVIKOVA, J. POKORNÝ, N. JAKUBCOVÁ, S. LUDHA, S. GURSKÁ, J. ŘEHULKA, B. LIŠKOVÁ, P. DŽUBÁK, M. HAJDÚCH, M. URBAN
Novel C-2 Aromatic Heterocycle-Substituted Triterpenoids Inhibit Hedgehog Signaling in GLI1 Overexpression Cancer Cells. ACS Omega. 2025, 10(10), 10617-10632, ISSN: 2470-1343, PMID: 40124057,  PDF.
DUMUT, D., M. HAJDÚCH, A. ZACHARIAS, Q. DUAN, I. FRYDRYCH, Z. ROŽÁNKOVÁ, M. POPPER, D. GARIC, R. PAUN, A. CENTORAME, J. SHAH, M. MISTRÍK, P. DŽUBÁK, J. DE SANCTIS, D. RADZIOCH
Diethyldithiocarbamate-copper complex ignites the tumor microenvironment through NKG2D-NKG2DL axis. Frontiers in Immunology. 2025, 16, 1491450, ISSN: 1664-3224 , PMID: 40013140,  PDF.
LIGASOVÁ, A., I. FRYDRYCH, B. PISKLÁKOVÁ, D. FRIEDECKÝ, K. KOBERNA
The kinetics of uracil-N-glycosylase distribution inside replication foci. Scientific Reports. 2025, 15(1), 3026, ISSN: 2045-2322, PMID: 39849039,  PDF.

Books & book chapters

FRYDRYCH, I.
Reporters based on luminescence or fluorescence detection , 1.vyd., Olomouc, Palacky University, 2021, 20, 147-152, Dedication: LO1304, ISBN: 978-80-244-6049-9,
FRYDRYCH, I.
Cell cycle analysis by flow cytometry , 1.vyd., Olomouc, Palacky University, 2021, 26, 193-200, Dedication: LO1304, ISBN: 978-80-244-6049-9,

Intellectual property

SONIC HEDGEHOG (Urban)
  1. Patent: CZ 309885. Granted: 30.11.2023. Ownership: Palacký University Olomouc. Inventors: URBAN Milan, FRYDRYCH Ivo, BORKOVÁ Lucie, VRÁNOVÁ Barbora, HAJDÚCH Marián. 

Status: Terminated

METHOD OF PREDICTING THE TUMOR RESPONSE TO DNA METHYLATION INHIBITORS AND ALTERNATIVE THERAPEUTIC REGIMENS FOR OVERCOMING RESISTANCE (Khushboo)
  1. Patent: EP 2924125 (ASH1L). Granted: 17.6.2017. Ownership: Palacký University Olomouc. Inventors: AGRAWAL Khushboo, FRYDRYCH Ivo, DŽUBÁK Petr, HAJDÚCH Marián
  2. Patent: EP 3042650 (JQ1). Granted: 10.6.2020. Ownership: Palacký University Olomouc. Inventors: AGRAWAL Khushboo, FRYDRYCH Ivo, DŽUBÁK Petr, HAJDÚCH Marián
  3. Published Application PCT/CZ2015/000029 under WO 2015/144102 (1.10.2015)
  4. Patent: EP 3122902 (BRD4). Granted: 16.5.2018. Ownership: Palacký University Olomouc. Inventors: AGRAWAL Khushboo, FRYDRYCH Ivo, DŽUBÁK Petr, HAJDÚCH Marián
  5. Published Application US 15/128,390 under US 20180251847 (6.9.2018)
  6. Patent: JP 6463372 (BRD4). Granted: 11.1.2019. Ownership: Palacký University Olomouc. Inventors: AGRAWAL Khushboo, FRYDRYCH Ivo, DŽUBÁK Petr, HAJDÚCH Marián

​Status: Terminated 

Master mentorship

Reiterová Ivana

Preparation of cell-based reporter assay for high-throughput screening of small molecules as potential receptor for advanced glycation endproducts inhibitors

Status: Graduated from 2015 to 2017.

Bachelor mentorship

Kollárová Ema

Study of biological activity of new betulin derivatives

Status: Ongoing from 2023.
Pitnerová Monika

Targeting Hedgehog signaling by betulinic acid derivatives

Status: Ongoing from 2021.