Frydrych Ivo Ph.D.

Phone: +420 585 632 145
Curriculum Vitae: download here

My research interests focus on development and validation of cellular gen reporters for high-throughput screening (HTS) of biologically active compounds. I´m working on a development of luminiscent technologies for mapping of cell signalling pathways activation/inhibition  as a powerful tool for assessing the biological impact of small molecule compounds. The another goal is development of cellular fluorescent  models for monitoring cell death hallmarks. My current research focuses on the investigation of pyrimidine derivatives as potential inhibitors of RAGE receptor, which is implicated in the regulation of diverse pathological conditions such as cancer, neurodegenerative diseases, diabetes or inflammation.

Publications (Impact Factor Journals)

  • [12]
    BORKOVÁ, L., I. FRYDRYCH, N. JAKUBCOVÁ, R. ADÁMEK, B. LIŠKOVÁ, S. GURSKÁ, M. MEDVEDÍKOVÁ, M. HAJDÚCH a M. URBAN. Synthesis and biological evaluation of triterpenoid thiazoles derived from betulonic acid, dihydrobetulonic acid, and ursonic acid. European Journal of Medicinal Chemistry. 2019, 185, 111806. ISSN 0223-5234. IF: 4.833. PMID: 31677446
  • [11]
    TOKARENKO, A., B. LIŠKOVÁ, S. SMOLEN, N. TÁBORSKÁ, M. TICHÝ, S. GURSKÁ, P. PERLÍKOVÁ, I. FRYDRYCH, E. TLOUŠŤOVÁ, P. ZNOJEK, H. MERTLIKOVA-KAISEROVA, L. POSTOVA SLAVETINSKA, R. POHL, B. KLEPETAROVA, N. KHALID, Y. WENREN, R. LAPOSA, P. DŽUBÁK, M. HAJDÚCH a M. HOCEK. Synthesis and Cytotoxic and Antiviral Profiling of Pyrrolo- and Furo-fused 7-Deazapurine Ribonucleosides. Journal of Medicinal Chemistry. 2018, 61(20), 9347-9359. ISSN 0022-2623. IF: 6.253. PMID: 30281308
  • [10]
    JURÁŠEK, M., M. CERNOHORSKA, J. ŘEHULKA, V. SPIWOK, T. SULIMENKO, E. DRABEROVA, M. DARMOSTUK, S. GURSKÁ, I. FRYDRYCH, R. BURIÁNOVÁ, T. RUML, M. HAJDÚCH, P. BARTŮNĚK, P. DRABER, P. DŽUBÁK, P. DRAŠAR a D. SEDLÁK. Estradiol Dimer Inhibits Tubulin Polymerization and Microtubule Dynamics. The Journal of Steroid Biochemistry and Molecular Biology. 2018, 183, 68-79. ISSN 0960-0760. IF: 4.561. PMID: 29803726
  • [9]
    WONG, A., D. BRYZEK, E. DOBOSZ, C. SCAVENIUS, P. SVOBODA, M. RAPALA-KOZIK, A. LESNER, I. FRYDRYCH, J. ENGHILD, P. MYDEL, J. POHL, P. THOMPSON, J. POTEMPA a J. KOZIEL. A Novel Biological Role for Peptidyl-Arginine Deiminases: Citrullination of Cathelicidin LL-37 Controls the Immunostimulatory Potential of Cell-Free DNA. Journal of Immunology. 2018, 200(7), 2327-2340. ISSN 0022-1767. IF: 4.856. PMID: 29475987
  • [8]
    ŘEHULKA, J., N. ANNADURAI, I. FRYDRYCH, P. DŽUBÁK, M. MILLER, M. HAJDÚCH a V. DAS. Peloruside A-Induced Cell Death in Hypoxia Is p53 Dependent in HCT116 Colorectal Cancer Cells. Journal of Natural Products. 2018, 81(3), 634-640. ISSN 0163-3864. IF: 3.281. PMID: 29400463
  • [7]
    LIGASOVÁ, A., P. KONEČNÝ, I. FRYDRYCH a K. KOBERNA. Cell cycle profiling by image and flow cytometry: The optimised protocol for the detection of replicational activity using 5-Bromo-2'-deoxyuridine, low concentration of hydrochloric acid and exonuclease III. PLOS One. 2017, 12(4), e0175880. ISSN 1932-6203. IF: 3.057. PMID: 28426799
  • [6]
    ŘEHULKA, J., N. ANNADURAI, I. FRYDRYCH, P. ZNOJEK, P. DŽUBÁK, P. NORTHCOTE, J.H. MILLER, M. HAJDÚCH a V. DAS. Cellular effects of the microtubule-targeting agent peloruside A in hypoxia-conditioned colorectal carcinoma cells. Biochimica et Biophysica Acta. 2017, 17, 30124-1. ISSN 0304-4165. IF: 5.083. PMID: 28366502
  • [5]
    LIGASOVÁ, A., P. KONEČNÝ, I. FRYDRYCH a K. KOBERNA. Looking for ugly ducklings: The role of the stability of BrdU-antibody complex and the improved method of the detection of DNA replication. PLOS One. 2017, 12(3), e0174893. ISSN 1932-6203. IF: 3.057. PMID: 28358913
  • [4]
    JURÁŠEK, M., P. DŽUBÁK, S. RIMPELOVA, D. SEDLÁK, P. KONEČNÝ, I. FRYDRYCH, S. GURSKÁ, M. HAJDÚCH, K. BOGDANOVÁ, M. KOLÁŘ, T. MÜLLER, E. KMONICKOVA, T. RUML, J. HARMATHA a P. DRAŠAR. Trilobolide-steroid hybrids: Synthesis, cytotoxic and antimycobacterial activity. Steroids. 2017, 117(2017), 97-104. ISSN 0039-128X. IF: 2.513. PMID: 27543674
  • [3]
    MISTRÍK, M., E. VESELÁ, T. FÜRST, H. HANZLIKOVA, I. FRYDRYCH, J. GURSKÝ, D. MAJERA a J. BÁRTEK. Cells and Stripes: A novel quantitative photo-manipulation technique. Scientific Reports. 2016, 6(-), Article Number: 19567. ISSN 2045-2322. IF: 4.259. PMID: 26777522
  • [2]
    BORKOVÁ, L., L. JASILKOVA, J. ŘEHULKA, K. FRISONSOVA, M. URBAN, I. FRYDRYCH, I. POPA, M. HAJDÚCH, N.J. DICKINSON, M. VLK, P. DŽUBÁK a J. ŠAREK. Synthesis of cytotoxic 2,2-difluoroderivatives of dihydrobetulinic acid and allobetulin and study of their impact on cancer cells. European Journal of Medicinal Chemistry. 2015, 96(-), 482-490. ISSN 0223-5234. IF: 3.902. PMID: 25942059
  • [1]
    KAPLANEK, R., M. JAKUBEK, J. RAK, Z. KEJIK, M. HAVLIK, B.. DOLENSKY, I. FRYDRYCH, M. HAJDÚCH, M. KOLÁŘ, K. BOGDANOVÁ, J. KRALOVA, P. DŽUBÁK a V. KRAL. Caffeine-hydrazones as anticancer agents with pronounced selectivity toward T-lymphoblastic leukaemia cells. Bioorganic Chemistry. 2015, 60(-), 19-29. ISSN 0045-2068. IF: 2.252. PMID: 25912310

  • Patents, Utility models & other IP's :

    1. Patent appl. EP 14161897.5 (ASH1L), Patent: EP 2924125, Granted: 17. 6. 2017, Ownership: Palacky University Olomouc, Inventors: Agrawal Khushboo, Frydrych Ivo, Džubák PetrHajdúch Marián
    2. Published Application EP 16158309.1 (JQ1) [divisional] under EP 3042650 (13. 7. 2016)
    3. Published Application PCT/CZ2015/000029 under WO 2015/144102 (1. 10. 2015)
    4. Patent appl. EP 15717786.6 (BRD4), Patent: EP 3122902, Granted: 16. 5. 2018, Ownership: Palacký University, Olomouc, Inventors: Agrawal KhushbooFrydrych IvoDžubák PetrHajdúch Marián
    5. Published Application US 15/128,390 under US 20180251847 (6.9.2018)
    6. Patent appl. JP 2016-559355 (BRD4), Patent: JP 6463372, Granted: 11. 1. 2019, Ownership: Palacký University, Olomouc, Inventors: Agrawal KhushbooFrydrych IvoDžubák PetrHajdúch Marián

    ​Status: Available 

    Master students mentor:

    [1] Ivana Reiterová, Preparation of cell-based reporter assay for high-throughput screening of small molecules as potential receptor for advanced glycation endproducts inhibitors,
    status: Graduated, from: 2015 to 2017