Institute of Molecular and Translational Medicine

REVIEW: Coronavirus infection: An immunologists' perspective

Coronavirus infections are frequent viral infections in several species. As soon as the severe acute respiratory syndrome (SARS) appeared in the early 2000s, most of the research focused on pulmonary disease. However, disorders in immune response and organ dysfunctions have been documented. Elderly individuals with comorbidities exhibit worse outcomes in all the coronavirus that cause SARS.

A breakthrough method in the research of the proteotoxic stress of cells

Scientists have unveiled a breakthrough method in the research of the proteotoxic stress of cells that leads to neurodegenerative diseases and cancer.

IMTM's director Marián Hajdúch is a member of The Research, Development and Innovation Council

We are pleased to inform you that the director of ÚMTM Marián Hajdúch has become a member of The Research, Development and Innovation Council (R&D&I Council). R&D&I Council is a professional and consultancy body of the Government of the Czech Republic in the field of research, experimental development and innovation.

IMTM WILL BE PART OF THE OF THE CZECH ADVANCED TECHNOLOGY AND RESEARCH INSTITUTE

The Palacký University Academical Senate has approved the Statute of the Czech Advanced Technology and Research Institute of the Palacky University (CATRIN), a new university institute into which university research centers will be integrated.

IMTM DECLARES WAR AGAINST COVID - 19

We confirm that the Laboratory of Experimental Medicine of the Institute of Molecular and Translational Medicine is in the final phase of implementation of high-throughput testing.

MOLECULAR BASIS OF DISEASES AND MOLECULAR TARGET

Research program aims at identification and description of metabolic pathways, signaling pathways, genetic and epigenetic changes causing human diseases, particularly focusing cancer, inflammatory and infectious diseases.

WELCOME TO INSTITUTE OF MOLECULAR AND TRANSLATIONAL MEDICINE

The institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacký University in Olomouc is cutting-edge biomedical research institute in the Czech Republic. IMTM is a leading Czech translational medicine institute established in 2010.

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Featured publications

VAN GOOL, A., F. BIETRIX, E. CALDENHOVEN, K. ZATLOUKAL, A. SCHERER, J. LITTON, G. MEIJER, N. BLOMBERG, A. SMITH, B. MONS, J. HERINGA, W. KOOT, M. SMIT, M. HAJDÚCH, T. RIJNDERS a A.E.

USSI. Bridging the translational innovation gap through good biomarker practice. Nature Reviews. Drug Discovery. 2017, 16(9), 587-588. ISSN 1474-1776 . IF: 57.000. PMID: 28450744

GILLILAND, C.T., D. ZUK, P. KOCIS, M. JOHNSON, S. HAY, M. HAJDÚCH, F. BIETRIX, G. AVERSA, C.P. AUSTIN a A.E.

USSI. Putting translational science on to a global stage. Nature Reviews Drug Discovery. 2016, 15, 217-219. ISSN 1474-1776. IF: 57.000. PMID: 27032820

MAYA-MENDOZA, A., P. MOUDRÝ, J. MERCHUT-MAYA, M. LEE, R. STRAUSS a J. BÁRTEK.

High speed of fork progression induces DNA replication stress and genomic instability. Nature. 2018, 559(7713), 279-284. ISSN 0028-0836. IF: 41.577. PMID: 29950726

ŠKROTT, Z., M. MISTRÍK, K. ANDERSEN, S. FRIIS, D. MAJERA, J. GURSKÝ, T. OŽDIAN, J. BARTKOVA, Z. TURI, P. MOUDRÝ, M. KRAUS, M. MEDVEDÍKOVÁ, J. VÁCLAVKOVÁ, P. DŽUBÁK, I. VROBEL, P. POUCKOVA, J. SEDLACEK, A. MIKLOVICOVA, A. KUTT, J. MATTOVA, C. DRIESSEN, Q. DOU, J. OLSEN, M. HAJDÚCH, B. CVEK, R. DESHAIES a J. BÁRTEK.

Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4. Nature. 2017, 552(7684), 194-199. ISSN 0028-0836. IF: 40.137. PMID: 29211715

XU, G., J. CHAPMAN, I. BRANDSMA, J. YUAN, M. MISTRÍK, P. BOUWMAN, J. BARTKOVA, E. GOGOLA, D. WARMERDAM, M. BAZARAS, J. JASPERS, K. WATANABE, M. PIETERSE, K. KERSBERGEN, W. SOL, P. CELIE, P. SCHOUTEN, B. VAN DEN BROEK, A. SALMAN, M. NIEUWLAND, I. DE RINK, J. DE RONDE, K. JALINK, S. BOULTON, J. CHEN, D. VAN GENT, J. BÁRTEK, J. JONKERS, P. BORST a S. ROTTENBERG.

REV7 counteracts DNA double-strand break resection and affects PARP inhibition. Nature. 2015, 521(7553), 541-544. ISSN 0028-0836. IF: 38.138. PMID: 25799992

DIETLEIN, F., B. KALB, M. JOKIC, E. NOLL, A. STRONG, L. THARUN, L. OZRETIC, H. KUNSTLINGER, K. KAMBARTEL, W. RANDERATH, C. JUNGST, A. SCHMITT, A. TORGOVNICK, A. RICHTERS, D. RAUH, F. SIEDEK, T. PERSIGEHL, C. MAUCH, J. BARTKOVA, A. BRADLEY, M. SPRICK, A. TRUMPP, R. RAD, D. SAUR, J. BÁRTEK, J. WOLF, R. BUTTNER, R. THOMAS a H. REINHARDT.

A Synergistic Interaction between Chk1-and MK2 Inhibitors in KRAS-Mutant Cancer. Cell. 2015, 162(1), 146-159. ISSN 0092-8674. IF: 28.710. PMID: 26140595

ALL PUBLICATIONS

REVIEW: Coronavirus infection: An immunologists' perspective

A breakthrough method in the research of the proteotoxic stress of cells

IMTM's director Marián Hajdúch is a member of The Research, Development and Innovation Council

IMTM WILL BE PART OF THE OF THE CZECH ADVANCED TECHNOLOGY AND RESEARCH INSTITUTE

IMTM DECLARES WAR AGAINST COVID - 19

MOLECULAR BASIS OF DISEASES AND MOLECULAR TARGET

WELCOME TO INSTITUTE OF MOLECULAR AND TRANSLATIONAL MEDICINE

News

REVIEW: Coronavirus infection: An immunologists' perspective

Marián Hajdúch talks about the development of the pandemic before the first spring concert of the Czech Phil

World success of Czech scientists: A breakthrough method can help in the treatment of Alzheimer's disease or cancer

A breakthrough method in the research of the proteotoxic stress of cells

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Featured publications

VAN GOOL, A., F. BIETRIX, E. CALDENHOVEN, K. ZATLOUKAL, A. SCHERER, J. LITTON, G. MEIJER, N. BLOMBERG, A. SMITH, B. MONS, J. HERINGA, W. KOOT, M. SMIT, M. HAJDÚCH, T. RIJNDERS a A.E.

GILLILAND, C.T., D. ZUK, P. KOCIS, M. JOHNSON, S. HAY, M. HAJDÚCH, F. BIETRIX, G. AVERSA, C.P. AUSTIN a A.E.

MAYA-MENDOZA, A., P. MOUDRÝ, J. MERCHUT-MAYA, M. LEE, R. STRAUSS a J. BÁRTEK.

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