Urban Milan Ph.D.

Journals

BACHOŘÍK, J., I. FRYDRYCH, S. GURSKÁ, S. DOSTAL, J. POKORNÝ, M. HAJDÚCH, M. URBAN
New Synthetic Approach to C‑30 Ethers, Esters, and Amines of Betulin Using the Mitsunobu Reaction and Biological Evaluation of the Products. ACS Omega. 2026, 11(16), 24564-24579, ISSN: 2470-1343, PMID: 42077890,  PDF.
ORSÁG, Š., I. FRYDRYCH, B. LIŠKOVÁ, S. GURSKÁ, A. PRIBYLKA, J. HODOŇ, P. DŽUBÁK, M. HAJDÚCH, M. URBAN
Synthesis and biological evaluation of novel C-30 modified lupane triterpenoids selectively cytotoxic against cancer cells. European Journal of Medicinal Chemistry. 2025, 302 (Pt 1), 118268, ISSN: 0223-5234 , PMID: 41124881,  PDF.
FRYDRYCH, I., J. ŘEHULKA, L. SLAVIKOVA, J. HODOŇ, J. HODOŇ, J. POKORNÝ, V. ŠIDOVÁ, M. MEDVEDÍKOVÁ, H. SLAVÍK, P. POLISHCHUK, T. OŽDIAN, J. VRBKOVÁ, J. ŠAREK, P. DŽUBÁK, M. HAJDÚCH, M. URBAN
Triterpenoid derivatives inhibit Gli-mediated transcription in human glioblastoma cell line via direct interaction with Gli1. The Journal of biological chemistry. 2025, ISSN: 0021-9258, PMID: 40651614,  PDF.

Books & book chapters

DŽUBÁK, P., M. URBAN, M. HAJDÚCH
Vývoj nových léčiv, 1. vyd, Praha, Galén, 2015, 11, 469-472, ISBN: 978-80-7492-121-6,
URBAN, M., M. KVASNICA, N. DICKINSON, J. ŠAREK
Biologically Active Triterpenoids Usable As Prodrugs, 1. vyd, New York, USA, Nova Science Publishers, 2015, 2, 25-50, Dedication: CZ.1.05/2.1.00/01.0030, ISBN: 978-1-63463-656-8,
ŠAREK, J., M. KVASNICA, M. VLK, M. URBAN, P. DŽUBÁK, M. HAJDÚCH
The Potential of Triterpenoids in the Treatment of Melanoma, 1.vyd, Rijeka, InTech, 2011, 7, 125-158, Dedication: 305/09/1216, ISBN: 978-953-307-293-7,

Intellectual property

TERPENOID DERIVATIVES, PHARMACEUTICAL PREPARATIONS CONTAINING THESE DERIVATIVES AND THEIR USE IN NEUROPROTECTION - PV 2020-651 (Urban)
  1. Published Application PCT/CZ2021/050146 under WO 2022/117133 (9.6.2022). 
  2. Published Application US 18/036,564

  3. Published Application EP 21827174.0 

    Ownership: Palacký University Olomouc. Inventors: URBAN Milan, GONZALEZ Gabriel, HODOŇ Jiří, STRNAD Miroslav

    Status: Patent pending

Doctoral mentorship

Bachořík Jan

Preparation of semisynthetic triterpenes

Status: Ongoing from 2019.
Orság Šimon

Preparation of new heterocyclic derivatives of triterpene

Status: Ongoing from 2022 to 2022.
Jurčeka Ondřej

Modification of lupine triterpenes in position C-17

Status: Ongoing from 2022.

Master mentorship

Horka Vladimír

Conjugates of betulin prepared by cycloaddition reactions

Status: Graduated from 2018 to 2020.
Pisár Martin

Preparation of semisynthetic derivatives of betulinic acid with cytotoxic activity

Status: Graduated from 2017 to 2019.
Olejníková Denisa

Synthesis of new lupane derivatives modified at position 20 or 30

Status: Graduated from 2018 to 2020.

Bachelor mentorship

Zamazal Viktor

Preparation of new triterpene derivatives based on sulfur

Status: Graduated from 2022 to 2024.
Jarošová Amálie

Preparation of new nitrogen-based triterpene derivatives

Status: Ongoing from 2022.
Oriešková Eliška

Preparation of new triterpene derivatives based on peptides

Status: Graduated from 2022 to 2024.

Open positions

Project: Natural compounds with anti tumor activity
Supervisors: Urban Milan Ph.D.
Available: 2
Intended for: Doctoral training
Summary: 2 full-time positions
Project: Research and development of agents for cancer, neurodegenerative and infectious diseases
Supervisors: De Sanctis Juan Bautista Ph.D., Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D., Urban Milan Ph.D., Das Viswanath M.Sc., Ph.D.
Available: 5
Intended for: Doctoral training