Lišková Barbora Ph.D.
About me
Publications
DNA interactions of 2-pyrrolinodoxorubicin, a distinctively more potent daunosamine-modified analogue of doxorubicin. Stepankova J, Studenovsky M, Malina J, Kasparkova J, Liskova B, Novakova O, Ulbrich K, Brabec V. Biochem Pharmacol. 2011 Aug 1;82(3):227-35.
Cellular response to antitumor cis-Dichlorido platinum(II) complexes of CDK inhibitor Bohemine and its analogues. Liskova B, Zerzankova L, Novakova O, Kostrhunova H, Travnicek Z, Brabec V. Chem Res Toxicol. 2012 Feb 20;25(2):500-9.
Bipyrimidine ruthenium(II) arene complexes: structure, reactivity and cytotoxicity. Betanzos-Lara S, Novakova O, Deeth RJ, Pizarro AM, Clarkson GJ, Liskova B, Brabec V, Sadler PJ, Habtemariam A. J Biol Inorg Chem. 2012 Oct;17(7):1033-51.
Conformation and recognition of DNA damaged by antitumor cis-dichlorido platinum(II) complex of CDK inhibitor bohemine. Novakova O, Liskova B, Vystrcilova J, Suchankova T, Vrana O, Starha P, Travnicek Z, Brabec V. Eur J Med Chem. 2014 May 6;78:54-64.
Effect of defined green tea extract in various dosage schemes on drug-metabolizing enzymes in mice in vivo. Matouskova P, Bartikova H, Bousova I, Szotakova B, Martin J, Skorkovska J, Hanusova V, Tomankova V, Anzenbacherova E, Liskova B, Anzenbacher P, Skalova L. Journal of functional foods 10 (2014) 327–335
Influence of diet supplementation with green tea extract on drug-metabolizing enzymes in a mouse model of monosodium glutamate-induced obesity. Bousova I, Matouskova P, Bartikova H, Szotakova B, Hanusova V, Tomankova V, Anzenbacherova E, Liskova B, Anzenbacher P, Skalova L. Eur J Nutr. 2015 Feb 8. [Epub ahead of print]
Altered cytochrome P450 activities and expression levels in liver and intestines of monosodium glutamate-induced mouse model of human obesity. Tomankova V, Liskova B, Skalova L, Bartikova H, Bousova I, Jourova L, Anzenbacher P, Ulrichova J, Anzenbacherova E. Life Sci. 2015 Jul 15;133:15-20. doi: 10.1016/j.lfs.2015.04.014. Epub 2015 May 18.
Evaluation of possible inhibition of human liver drug metabolizing cytochromes P450 by two new acetylcholinesterase oxime-type reactivators. Spicakova A, Anzenbacher P, Liskova B, Kuca K, Fusek J, Anzenbacherova E. Food Chem Toxicol. 2016 Feb;88:100-4. doi: 10.1016/j.fct.2015.11.024
The reverse role of the hypothalamic paraventricular (PVN) and arcuate (ARC) nuclei in the central serotonergic regulation of the liver cytochrome P450 isoform CYP2C11. Rysz M, Bromek E, Haduch A, Liskova B, Wójcikowski J, Daniel WA. Biochem Pharmacol. 2016 Jul 15;112:82-9. doi: 10.1016/j.bcp.2016.04.017
Impact factor journals
Book chapters
Master mentorship
Křištofová Kateřina
ADME as support for the doscovery of new drugs in preclinical development
Kašparpová Zdena
The role of the absorption, distribution, metabolism and excretion in a drug discovery in preclinical development
Krupicová Kateřina
Study of the basic pharmacokinetic properties of a new drug candidates in preclinical development
Bachelor mentorship
Krupicová Kateřina
Study of the basic pharmacokinetic properties of a new drug candidates in preclinical development
Open positions
| Project: | Pharmacokinetic methods in preclinical drug testing |
|---|---|
| Supervisors: | Hajdúch Marián M.D., Ph.D., Lišková Barbora Ph.D. |
| Available: | 1 |
| Intended for: | Doctoral training |
| Summary: | The study of ADME properties of a potential drug that are part of the IMTM chemical library - obtained by national or international cooperation belongs to one of the first steps in predicting potential drugs. In vitro models generate many ADME parameters, including chemical, plasma and microsomal stability, plasma protein binding and proportion of passive diffusion as a transport mechanism. The Caco-2 and MDCK-MDR1 permeability assays are established models of intestinal and blood-brain barriers, respectively. Analysis of samples is performed using a Agilent RapidFire 300 - rapid online solid phase extraction with subsequent detection of the mass spectrometer Qtrap 5500 (AB Sciex) - RF/MS. High-Throughput Mass Spectrometry System RF/MS delivers ultrafast, label – free analysis of native compounds for biochemical assays in ADME and provide throughput speeds of 6 to 10 seconds per sample. |
| Project: | Study of basic pharmacokinetic properties (ADME) of new drugs in preclinical development |
|---|---|
| Supervisors: | Lišková Barbora Ph.D. |
| Available: | 1 |
| Intended for: | Doctoral training |