Přejít k hlavnímu obsahu
Header image

Frydrych Ivo Ph.D.

Journals

Novel triterpenoid pyrones, phthalimides and phthalates are selectively cytotoxic in CCRF-CEM cancer cells - Synthesis, potency, and mitochondrial mechanism of action. European Journal of Medicinal Chemistry. 2024, 269, 116336, ISSN: 0223-5234, PMID: 38520761,  PDF.
Basic Methods of Cell Cycle Analysis. International Journal of Molecular Sciences. 2023, 24(12), 3674, ISSN: 1422-0067, PMID: 36835083,  PDF.
Lupane derivatives containing various aryl substituents in the position 3 have selective cytostatic effect in leukemic cancer cells including resistant phenotypes. European Journal of Medicinal Chemistry. 2022, 244, 114850, ISSN: 0223-5234, PMID: 36283179,

Books & book chapters

Reporters based on luminescence or fluorescence detection , 1.vyd., Olomouc, Palacky University, 2021, 20, 147-152, Dedication: LO1304, ISBN: 978-80-244-6049-9,
Cell cycle analysis by flow cytometry , 1.vyd., Olomouc, Palacky University, 2021, 26, 193-200, Dedication: LO1304, ISBN: 978-80-244-6049-9,

Intellectual property

SONIC HEDGEHOG (Urban)
  1. Patent: CZ 309885. Granted: 30.11.2023. Ownership: Palacký University Olomouc. Inventors: URBAN Milan, FRYDRYCH Ivo, BORKOVÁ Lucie, VRÁNOVÁ Barbora, HAJDÚCH Marián

Status: Available

METHOD OF PREDICTING THE TUMOR RESPONSE TO DNA METHYLATION INHIBITORS AND ALTERNATIVE THERAPEUTIC REGIMENS FOR OVERCOMING RESISTANCE (Khushboo)
  1. Patent: EP 2924125 (ASH1L). Granted: 17.6.2017. Ownership: Palacký University Olomouc. Inventors: AGRAWAL Khushboo, FRYDRYCH Ivo, DŽUBÁK PetrHAJDÚCH Marián
  2. Patent: EP 3042650 (JQ1). Granted: 10.6.2020. Ownership: Palacký University Olomouc. Inventors: AGRAWAL Khushboo, FRYDRYCH Ivo, DŽUBÁK PetrHAJDÚCH Marián
  3. Published Application PCT/CZ2015/000029 under WO 2015/144102 (1.10.2015)
  4. Patent: EP 3122902 (BRD4). Granted: 16.5.2018. Ownership: Palacký University Olomouc. Inventors: AGRAWAL Khushboo, FRYDRYCH Ivo, DŽUBÁK PetrHAJDÚCH Marián
  5. Published Application US 15/128,390 under US 20180251847 (6.9.2018)
  6. Patent: JP 6463372 (BRD4). Granted: 11.1.2019. Ownership: Palacký University Olomouc. Inventors: AGRAWAL Khushboo, FRYDRYCH Ivo, DŽUBÁK PetrHAJDÚCH Marián

​Status: Available 

Master mentorship

Reiterová Ivana

Preparation of cell-based reporter assay for high-throughput screening of small molecules as potential receptor for advanced glycation endproducts inhibitors

Stav: Absolvoval od 2015 do 2017.

Bachelor mentorship

Kollárová Ema

Study of biological activity of new betulin derivatives

Stav: Probíhající od 2023.
Pitnerová Monika

Targeting Hedgehog signaling by betulinic acid derivatives

Stav: Probíhající od 2021.