Frydrych Ivo Ph.D.

Journals

ORSÁG, Š., I. FRYDRYCH, B. LIŠKOVÁ, S. GURSKÁ, A. PRIBYLKA, J. HODOŇ, P. DŽUBÁK, M. HAJDÚCH, M. URBAN
Synthesis and biological evaluation of novel C-30 modified lupane triterpenoids selectively cytotoxic against cancer cells. European Journal of Medicinal Chemistry. 2025, 302 (Pt 1), 118268, ISSN: 0223-5234 , PMID: 41124881,  PDF.
DAS, V., S. MODARRES MOUSAVI, N. ANNADURAI, S. SUKUR, F. MEHRNEJAD, M. MORADI, L. MALINA, M. KOLARIKOVA, V. RANC, I. FRYDRYCH, R. KOURIL, S. HOSSEINKHANI, M. HAJDÚCH, M. NIKKHAH
Hydrophobic residues in the α-synuclein NAC domain drive seed-competent fibril formation and are targeted by peptide inhibitors. Federation of European Biochemical Societies. 2025, ISSN: 1742-464X, PMID: 40819250,  PDF.
FRYDRYCH, I., J. ŘEHULKA, L. SLAVIKOVA, J. HODOŇ, J. HODOŇ, J. POKORNÝ, V. ŠIDOVÁ, M. MEDVEDÍKOVÁ, H. SLAVÍK, P. POLISHCHUK, T. OŽDIAN, J. VRBKOVÁ, J. ŠAREK, P. DŽUBÁK, M. HAJDÚCH, M. URBAN
Triterpenoid derivatives inhibit Gli-mediated transcription in human glioblastoma cell line via direct interaction with Gli1. The Journal of biological chemistry. 2025, ISSN: 0021-9258, PMID: 40651614,  PDF.

Books & book chapters

FRYDRYCH, I.
Reporters based on luminescence or fluorescence detection , 1.vyd., Olomouc, Palacky University, 2021, 20, 147-152, Dedication: LO1304, ISBN: 978-80-244-6049-9,
FRYDRYCH, I.
Cell cycle analysis by flow cytometry , 1.vyd., Olomouc, Palacky University, 2021, 26, 193-200, Dedication: LO1304, ISBN: 978-80-244-6049-9,

Intellectual property

SONIC HEDGEHOG (Urban)
  1. Patent: CZ 309885. Granted: 30.11.2023. Ownership: Palacký University Olomouc. Inventors: URBAN Milan, FRYDRYCH Ivo, BORKOVÁ Lucie, VRÁNOVÁ Barbora, HAJDÚCH Marián. 

Status: Terminated

METHOD OF PREDICTING THE TUMOR RESPONSE TO DNA METHYLATION INHIBITORS AND ALTERNATIVE THERAPEUTIC REGIMENS FOR OVERCOMING RESISTANCE (Khushboo)
  1. Patent: EP 2924125 (ASH1L). Granted: 17.6.2017. Ownership: Palacký University Olomouc. Inventors: AGRAWAL Khushboo, FRYDRYCH Ivo, DŽUBÁK Petr, HAJDÚCH Marián
  2. Patent: EP 3042650 (JQ1). Granted: 10.6.2020. Ownership: Palacký University Olomouc. Inventors: AGRAWAL Khushboo, FRYDRYCH Ivo, DŽUBÁK Petr, HAJDÚCH Marián
  3. Published Application PCT/CZ2015/000029 under WO 2015/144102 (1.10.2015)
  4. Patent: EP 3122902 (BRD4). Granted: 16.5.2018. Ownership: Palacký University Olomouc. Inventors: AGRAWAL Khushboo, FRYDRYCH Ivo, DŽUBÁK Petr, HAJDÚCH Marián
  5. Published Application US 15/128,390 under US 20180251847 (6.9.2018)
  6. Patent: JP 6463372 (BRD4). Granted: 11.1.2019. Ownership: Palacký University Olomouc. Inventors: AGRAWAL Khushboo, FRYDRYCH Ivo, DŽUBÁK Petr, HAJDÚCH Marián

​Status: Terminated 

Master mentorship

Reiterová Ivana

Preparation of cell-based reporter assay for high-throughput screening of small molecules as potential receptor for advanced glycation endproducts inhibitors

Stav: Absolvoval od 2015 do 2017.

Bachelor mentorship

Kollárová Ema

Study of biological activity of new betulin derivatives

Stav: Absolvoval od 2023 do 2025.