Urban Milan Ph.D.

Academic title: Professor

Phone: +420 585 632 197

Groups: FACULTY OF SCIENCE, IMTM, MEDCHEM, STAFF, SUPERVISOR

I am a scientist in the field of medicinal chemistry with current focus on natural products with various biological activities. Since 2012 I am a leader of an independent research group that currently has 2 postdocs, 4 PhD and 8 undergraduate students. Our research consists of organic synthesis, evaluation of activities and mechanism of action. I have been a PI of several grant projects from Czech Science Agency and from the Ministry of Health of the Czech Republic. Currently I serve on an evaluation panel of Czech Science Agency (P207). Earlier in my career, I was also involved in nucleic acid research, enzymology and biochemistry in general. In addition, I teach classes on bioorganic chemistry, chemical biology, and chemistry of nucleic acids. Published more than 40 papers, 3 book chapters, 4 patents, >1500 SCI citations, H-index 21.

ORCID: http://orcid.org/0000-0002-8249-028X

Researcher ID: C-9611-2010

BACHOŘÍK, J., I. FRYDRYCH, S. GURSKÁ, S. DOSTAL, J. POKORNÝ, M. HAJDÚCH, M. URBAN

New Synthetic Approach to C‑30 Ethers, Esters, and Amines of Betulin Using the Mitsunobu Reaction and Biological Evaluation of the Products. ACS Omega. 2026, 11(16), 24564-24579, ISSN: 2470-1343, PMID: 42077890, PDF.

ORSÁG, Š., I. FRYDRYCH, B. LIŠKOVÁ, S. GURSKÁ, A. PRIBYLKA, J. HODOŇ, P. DŽUBÁK, M. HAJDÚCH, M. URBAN

Synthesis and biological evaluation of novel C-30 modified lupane triterpenoids selectively cytotoxic against cancer cells. European Journal of Medicinal Chemistry. 2025, 302 (Pt 1), 118268, ISSN: 0223-5234 , PMID: 41124881, PDF.

FRYDRYCH, I., J. ŘEHULKA, L. SLAVIKOVA, J. HODOŇ, J. HODOŇ, J. POKORNÝ, V. ŠIDOVÁ, M. MEDVEDÍKOVÁ, H. SLAVÍK, P. POLISHCHUK, T. OŽDIAN, J. VRBKOVÁ, J. ŠAREK, P. DŽUBÁK, M. HAJDÚCH, M. URBAN

Triterpenoid derivatives inhibit Gli-mediated transcription in human glioblastoma cell line via direct interaction with Gli1. The Journal of biological chemistry. 2025, ISSN: 0021-9258, PMID: 40651614, PDF.

DŽUBÁK, P., M. URBAN, M. HAJDÚCH

Vývoj nových léčiv, 1. vyd, Praha, Galén, 2015, 11, 469-472, ISBN: 978-80-7492-121-6,

URBAN, M., M. KVASNICA, N. DICKINSON, J. ŠAREK

Biologically Active Triterpenoids Usable As Prodrugs, 1. vyd, New York, USA, Nova Science Publishers, 2015, 2, 25-50, Dedication: CZ.1.05/2.1.00/01.0030, ISBN: 978-1-63463-656-8,

ŠAREK, J., M. KVASNICA, M. VLK, M. URBAN, P. DŽUBÁK, M. HAJDÚCH

The Potential of Triterpenoids in the Treatment of Melanoma, 1.vyd, Rijeka, InTech, 2011, 7, 125-158, Dedication: 305/09/1216, ISBN: 978-953-307-293-7,

TERPENOID DERIVATIVES, PHARMACEUTICAL PREPARATIONS CONTAINING THESE DERIVATIVES AND THEIR USE IN NEUROPROTECTION - PV 2020-651 (Urban)

Published Application PCT/CZ2021/050146 under WO 2022/117133 (9.6.2022).
Published Application US 18/036,564
Published Application EP 21827174.0
Ownership: Palacký University Olomouc. Inventors: URBAN Milan, GONZALEZ Gabriel, HODOŇ Jiří, STRNAD Miroslav
Status: Patent pending

Bachořík Jan

Preparation of semisynthetic triterpenes

Status: Ongoing from 2019.

2 Molecular and Translational Medicine

Project:	Research and development of agents for cancer, neurodegenerative and infectious diseases
Supervisors:	De Sanctis Juan Bautista Ph.D., Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D., Urban Milan Ph.D., Das Viswanath M.Sc., Ph.D.
Available:	5
Intended for:	Doctoral training

Project:	Natural compounds with anti tumor activity
Supervisors:	Urban Milan Ph.D.
Available:	2
Intended for:	Doctoral training
Summary:	2 full-time positions

Urban Milan Ph.D.

About me

Journals

Books & book chapters

Intellectual property

Doctoral mentorship

Bachořík Jan

Orság Šimon

Jurčeka Ondřej

Master mentorship

Horka Vladimír

Pisár Martin

Olejníková Denisa

Bachelor mentorship

Zamazal Viktor

Jarošová Amálie

Oriešková Eliška

Open positions