Hajdúch Marián M.D., Ph.D.

Academic title: Associate Professor

Phone: +420 585632082, +420 585632083

Groups: IMTM, LEM, STAFF, SUPERVISOR

Scientist and medical professional mainly involved in molecular and translational medicine (disease area oncology. rare and infectious diseases); long-term experience in project management; R&D and technology transfer activities, including the construction and management of large research infrastructures. Founding director of the Institute of Molecular and Translational Medicine, Palacky University in Olomouc, CZ. He has been involved as principal investigator, investigator or clinical site manager in 19 clinical trials; actively participated in the research and/or management of >50 national and international projects; established Cancer Research Czech Republic as a major charity to support cancer research in CZ; spin-off companies focused on manufacturing of molecular diagnostics, bioinformatics and drug development; leader/co-leader drug development initiatives with one registered drug on market, several products in clinical trials, >35 in vitro diagnostic products on market, several CE IVD certified. Former Chair of the Boards of National Director and current Czech National Director for European Translational Medicine Infrastructure (EATRIS-ERIC); participated in creation of national network for personalized medicine and cancer management policies. Published more than >350 papers, 21 books/chapters, >40 patents, >6700 SCI citations, H-index 41.

BHISE, P., S. BHISE, S. DASGUPTA, A. NANDY, R. GUNDLA, S. GURSKÁ, P. DŽUBÁK, M. HAJDÚCH, V. DAS, S. THOPATE, P. BADADHE

Design, synthesis, molecular docking and anticancer activity of novel N-(4-(chlorodifluoromethoxy)phenyl)-1 H-pyrrolo[2,3- b]pyridine-5-carboxamide derivatives. RSC Advances. 2026, ISSN: 2046-2069, PMID: 42729957, PDF.

DUMUT, D., Y. XU, D. VERELLI, V. DAS, M. HAJDÚCH, J. DE SANCTIS, D. RADZIOCH

Overcoming Resistance: Targeting Survivin-Driven Apoptotic Resistance Restores Irinotecan Sensitivity in TP53-Mutant Colorectal Cancer. Cancers (Basel). 2026, 18(16), 2687, ISSN: 2072-6694, PMID: 42649998, PDF.

BEJCEK, J., M. JURÁŠEK, M. KREISSLOVA, J. SKUBNIK, I. KRIZOVA, J. FAHNRICH, S. GURSKÁ, P. DŽUBÁK, M. HAJDÚCH, V. SPIWOK, P. DRAŠAR, T. RUML, S. RIMPELOVA

Click chemistry-based synthesis of fluorescent digitoxin derivatives with anticancer activity and cellular imaging potentia. RSC Advances. 2026, ISSN: 2046-2069, PMID: 42609921, PDF.

DRÁBEK, J., V. DAS, P. DŽUBÁK, J. SROVNAL, J. BOUCHAL, M. HAJDÚCH, K. KOBERNA, A. LIGASOVÁ, M. MISTRÍK, J. DE SANCTIS

Laboratory Techniques in Cellular and Molecular Medicine, 1.vyd., Olomouc, Palacky University, 2021, 436 s, Dedication: LO1304, ISBN: 978-80-244-6049-9,

KOUDELÁKOVÁ, V., M. HAJDÚCH

Predictive Cancer Biomarkers: Current Practice and Future Challenges, 1.vyd, Boca Raton, CRC Press, 2019, 7.5, 383-394, ISBN: 978-1-4987-6258-8,

BOUCHALOVÁ, K., M. HAJDÚCH, J. BOUCHAL, A. HLOBILKOVA, M. HOUDOVÁ MEGOVÁ, M. HUDCOVÁ, V. KOUDELÁKOVÁ, J. MEDALOVA, J. SROVNAL, R. TROJANEC

Prediktivní a prognostická onkologie, 1. vyd, Olomouc, Univerzita Palackého v Olomouci, 2016, 122 s, Dedication: CZ.1.07/2.3.00/09.0089, ISBN: 978-80-244-3188-8,

METHOD FOR NON-INVASIVE ASTHMA TREATMENT STRATIFICATION - EP 25223197.2 (Džubák)

Filed Application EP 25223197.2
Ownership: Palacký University Olomouc. Inventors: DŽUBÁK Petr, HAJDÚCH Marián, VÁCLAVKOVÁ Jana, KOUŘILOVÁ Pavla, KOPŘIVA František.
Status: Patent pending

HETEROCYCLIC COMPOUNDS FOR THE PREVENTION AND THERAPY OF CIRCADIAN RHYTHM DISORDERS - PV 2022-227 (Voller)

Published Application: PCT/CZ2023/050029 under WO 2023/232171 (7.12.2023)
Published Application US 18/868,011 under US 2025346601 (13.11.2025)
Patent: EP 4532498. Granted: 29.10.2025. Ownership: Palacký University Olomouc; Institute of Physiology CAS. Inventors: VOLLER Jiří, MIK Václav, DOKONALOVÁ Markéta, SLÁDEK Martin, SUMOVÁ Alena, HAJDÚCH Marián, STRNAD Miroslav.

Status: Available

RNA ISOLATION KIT - PUV 2020-38366 (Džubák)

Utility Model: CZ 35067. Granted: 18.5.2021. Ownership: Palacký University Olomouc. Inventors: DŽUBÁK Petr, HAJDÚCH Marián, GURSKÁ Soňa, KOUDELÁKOVÁ Vladimíra, JAWOREK Hana.

Status: Available

Dvořanová Štěpánková Jana Ph.D.

Novel Carborane Based Inhibitors of Carbonic Anhydrase IX

Status: Graduated.

Varanasi Lakshman Ph.D.

Identification and validation of serum-based biomarkers of gastrointestinal cancer in a mouse xenograft model

Status: Graduated.

Agrawal Khushboo Ph.D.

Status: Graduated.

Ondra Martin Ph.D.

Development and validation of luminescent HTS tool for discovery and optimization of novel combination of CFTR correctors and modifiers

Status: Graduated from 2017 to 2024.

Ziaei Nikta

Preparation of 3D cultures for high-throughput screening

Status: Ongoing from 2023.

Kubíčková Agáta Ph.D.

Role of transcription factor c-Myc in proliferation, quiscence, apoptosis and ribosomal biogenesis

Status: Graduated from 2016 to 2024.

1 Molecular and cellular biology

Project:	Identification of molecular targets and mechanisms of drug resistance by cellular methods biology and proteomics
Supervisors:	Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
Available:	2
Intended for:	Doctoral training
Summary:	2 places in full-time study

1 Medical chemistry and clinical biochemistry

Project:	Research and development of small-molecule drugs
Supervisors:	Hajdúch Marián M.D., Ph.D.
Available:	2
Intended for:	Doctoral training
Summary:	2 full-time positions

2 Biomarkers: Identification and validation

Project:	Identification of proteomic biomarkers in exhaled air condensate in patients with systemic or pulmonary disease
Supervisors:	Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
Available:	2
Intended for:	Doctoral training
Summary:	2 places in full-time study

Project:	Genetic and epigenetic biomarkers of cancer diseases
Supervisors:	Slavkovský Rastislav Ph.D., Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D., Drábek Jiří Ph.D.
Available:	3
Intended for:	Doctoral training
Summary:	3 places in full-time or combined form of study

3 Chemical biology and experimental therapeutics

Project:	Study of basic pharmacokinetic properties (ADME) of new drugs in preclinical development
Supervisors:	Lišková Barbora Ph.D., Hajdúch Marián M.D., Ph.D.
Available:	1
Intended for:	Doctoral training
Summary:	1 place in full-time study

Project:	Drug repurposing for the treatment and prevention of diseases
Supervisors:	Hajdúch Marián M.D., Ph.D., Dömling Alexander PhD.
Available:	1
Intended for:	Doctoral training
Summary:	1 place in full-time study

Project:	Antitumor drugs targeting nucleic acid metabolism
Supervisors:	Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D.
Available:	2
Intended for:	Doctoral training
Summary:	2 places in full-time study

1 Bioinformatics / Chemoinformatics

Project:	Bioinformatics processing of big data within clinical and preclinical studies
Supervisors:	Hajdúch Marián M.D., Ph.D., Pavliš Petr Ph.D.
Available:	3
Intended for:	Doctoral training
Summary:	3 places in full-time or combined form of study

16 Molecular and Translational Medicine

Project:	Identification of molecular targets and mechanisms of resistance in anticancer drugs using cell biology and proteomics
Supervisors:	Hajdúch Marián M.D., Ph.D.
Available:	1
Intended for:	Doctoral training
Summary:	1 full-time position

Project:	Anticancer drugs targeting nucleic acid metabolism
Supervisors:	Hajdúch Marián M.D., Ph.D.
Available:	1
Intended for:	Doctoral training
Summary:	1 full-time position

Project:	Bioinformatics processing of large datasets in clinical and preclinical studies
Supervisors:	Hajdúch Marián M.D., Ph.D., Pavliš Petr Ph.D.
Available:	2
Intended for:	Doctoral training
Summary:	2 positions (full-time or part-time)

Project:	Anticancer drugs targeting nucleic acid metabolism
Supervisors:	Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D.
Available:	2
Intended for:	Doctoral training

Project:	Identification of molecular targets and mechanisms of resistance in antitumor drugs
Supervisors:	Srovnal Josef M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
Available:	2
Intended for:	Doctoral training
Summary:	2 places in full-time study

Project:	Physiology and pathophysiology of aging
Supervisors:	Hajdúch Marián M.D., Ph.D., Voller Jiří Ph.D.
Available:	2
Intended for:	Doctoral training
Summary:	2 places in full-time study

Project:	Development of drugs in the field of small molecules 2 places in full-time study
Supervisors:	Dömling Alexander PhD., Hajdúch Marián M.D., Ph.D.
Available:	2
Intended for:	Doctoral training
Summary:	2 places in full-time study

Project:	Diagnosis and treatment of rare diseases
Supervisors:	Hajdúch Marián M.D., Ph.D., Srovnal Josef M.D., Ph.D.
Available:	2
Intended for:	Doctoral training
Summary:	2 places in full-time study

Project:	Diagnosis and treatment of rare diseases
Supervisors:	Hajdúch Marián M.D., Ph.D., Srovnal Josef M.D., Ph.D., Adam Tomáš Ph.D.
Available:	3
Intended for:	Doctoral training
Summary:	3 full-time positions

Project:	Genetic and epigenetic biomarkers in health and disease
Supervisors:	Slavkovský Rastislav Ph.D., Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D., Drábek Jiří Ph.D., Koudeláková Vladimíra Ph.D.
Available:	5
Intended for:	Doctoral training

Project:	Identification of proteomic biomarkers in exhaled breath condensate patients with systemic or pulmonary disease
Supervisors:	Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
Available:	2
Intended for:	Doctoral training

Project:	Biologically active molecules and their therapeutic combinations
Supervisors:	Hajdúch Marián M.D., Ph.D.
Available:	2
Intended for:	Doctoral training

Project:	Identification of proteomic biomarkers in proximal fluids and tissues
Supervisors:	Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
Available:	2
Intended for:	Doctoral training

Project:	Research and development of agents for cancer, neurodegenerative and infectious diseases
Supervisors:	De Sanctis Juan Bautista Ph.D., Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D., Urban Milan Ph.D., Das Viswanath M.Sc., Ph.D.
Available:	5
Intended for:	Doctoral training

Project:	Identification of new derivatives targeting precancerous and tumor lesions and their mechanisms of action
Supervisors:	Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D.
Available:	2
Intended for:	Doctoral training
Summary:	2 full-time positions

Project:	New diagnostic, prognostic, and predictive factors in solid tumors
Supervisors:	Hajdúch Marián M.D., Ph.D.
Available:	2
Intended for:	Doctoral training
Summary:	2 positions (full-time or part-time)

Hajdúch Marián M.D., Ph.D.

About me

Journals

Books & book chapters

Intellectual property

Postdoctoral mentorship

Dvořanová Štěpánková Jana Ph.D.

Varanasi Lakshman Ph.D.

Agrawal Khushboo Ph.D.

Doctoral mentorship

Ondra Martin Ph.D.

Ziaei Nikta

Kubíčková Agáta Ph.D.

Open positions