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Frydrych Ivo Ph.D.

Journals

Basic Methods of Cell Cycle Analysis. International Journal of Molecular Sciences. 2023, 24(12), 3674, ISSN: 1422-0067, PMID: 36835083, DATA.
Lupane derivatives containing various aryl substituents in the position 3 have selective cytostatic effect in leukemic cancer cells including resistant phenotypes. European Journal of Medicinal Chemistry. 2022, 244, 114850, ISSN: 0223-5234, PMID: 36283179,
HODOŇ, J., I. FRYDRYCH, Z. TRHLÍKOVÁ, J. POKORNÝ, L. BORKOVÁ, S. BENICKÁ, M. VLK, B. LIŠKOVÁ, A. KUBÍČKOVÁ, M. MEDVEDÍKOVÁ, M. PISÁR, J. ŠAREK, V. DAS, A. LIGASOVÁ, K. KOBERNA, P. DŽUBÁK, M. HAJDÚCH, M. URBAN
Triterpenoid pyrazines and pyridines - Synthesis, cytotoxicity, mechanism of action, preparation of prodrugs. European Journal of Medicinal Chemistry. 2022, 243, 114777, ISSN: 0223-5234, PMID: 36174412, DATA.

Books & book chapters

Reporters based on luminescence or fluorescence detection , 1.vyd., Olomouc, Palacky University, 2021, 20, 147-152, Dedication: LO1304, ISBN: 978-80-244-6049-9,
Cell cycle analysis by flow cytometry , 1.vyd., Olomouc, Palacky University, 2021, 26, 193-200, Dedication: LO1304, ISBN: 978-80-244-6049-9,

Intellectual property

METHOD OF PREDICTING THE TUMOR RESPONSE TO DNA METHYLATION INHIBITORS AND ALTERNATIVE THERAPEUTIC REGIMENS FOR OVERCOMING RESISTANCE (Khushboo)
  1. Patent appl. EP 14161897.5 (ASH1L); Patent: EP 2924125; Granted: 17.6.2017; Ownership: Palacky University Olomouc; Inventors: Agrawal Khushboo, Frydrych Ivo, Džubák PetrHajdúch Marián
  2. Patent appl. EP 16158309.1 (JQ1) [divisional]; Patent: EP 3042650; Granted: 14.5.2020; Ownership: Palacky University Olomouc; Inventors: Agrawal KhushbooFrydrych IvoDžubák PetrHajdúch Marián
  3. Published Application PCT/CZ2015/000029 under WO 2015/144102 (1.10.2015)
  4. Patent appl. EP 15717786.6 (BRD4); Patent: EP 3122902; Granted: 16.5.2018; Ownership: Palacký University Olomouc; Inventors: Agrawal KhushbooFrydrych IvoDžubák PetrHajdúch Marián
  5. Published Application US 15/128,390 under US 20180251847 (6.9.2018)
  6. Patent appl. JP 2016-559355 (BRD4); Patent: JP 6463372; Granted: 11.1.2019; Ownership: Palacký University Olomouc; Inventors: Agrawal KhushbooFrydrych IvoDžubák PetrHajdúch Marián

​Status: Available 

TRITERPENES WITH INHIBITORY ACTIVITY ON THE HEDGEHOG SIGNALING PATHWAY FOR USE IN THE TREATMENT OF CANCER DISEASES (Urban)
  1. Priority Application: PV 2022-277. Filed: 21.6.2022. Inventors: URBAN Milan, FRYDRYCH Ivo, BORKOVÁ Lucie, VRÁNOVÁ Barbora, HAJDÚCH Marián. Ownership: Palacký University Olomouc. 

Status: Patent pending; Available

Master mentorship

Reiterová Ivana

Preparation of cell-based reporter assay for high-throughput screening of small molecules as potential receptor for advanced glycation endproducts inhibitors

Status: Graduated from 2015 to 2017.

Bachelor mentorship

Kollárová Ema

Study of biological activity of new betulin derivatives

Status: Ongoing from 2023.
Pitnerová Monika

Targeting Hedgehog signaling by betulinic acid derivatives

Status: Ongoing from 2021.