Medicinal chemistry and bioactive natural products

Medicinal chemistry and bioactive natural products

Laboratory of Medicinal and Organic Chemistry

Senior research group

Our research group is currently focused on natural triterpenoids and their semi-synthetic analogues and on the studies of their biological activities. Based on the activities, we have two main domains of research.

Compounds with anti-cancer activity
Compounds with neuroprotective activity

Current projects

Modifications of the position C-30 in lupane triterpenoids
Triterpenoids with condensed heterocycle to the main skeleton
Fluorescently labelled triterpenoids and their visualization in the living environment
Bioorthogonal click-reaction of selectively cytotoxic triterpenes
Development of compounds selectively cytotoxic in resistant cancer cells
Compounds labelled with deuterium and their visualization using Raman confocal microscopy
Natural products with neuroprotective properties and elucitation of their mechanism of action

Journals

BORKOVÁ, L., I. FRYDRYCH, N. JAKUBCOVÁ, R. ADÁMEK, B. LIŠKOVÁ, S. GURSKÁ, M. MEDVEDÍKOVÁ, M. HAJDÚCH, M. URBAN

Synthesis and biological evaluation of triterpenoid thiazoles derived from betulonic acid, dihydrobetulonic acid, and ursonic acid. European Journal of Medicinal Chemistry. 2019, 185, 111806, ISSN: 0223-5234, PMID: 31677446,

BORKOVÁ, L., R. ADÁMEK, P. KALINA, P. DRAŠAR, P. DŽUBÁK, S. GURSKÁ, J. ŘEHULKA, M. HAJDÚCH, M. URBAN, J. ŠAREK

Synthesis and Cytotoxic Activity of Triterpenoid Thiazoles Derived from Allobetulin, Methyl Betulonate, Methyl Oleanonate, and Oleanonic Acid. ChemMedChem. 2017, 12(5), 390-398, ISSN: 1860-7179, PMID: 28084676,