Contakt

Škrott Zdeněk M.Sc.

Academic Title: Mgr.
E-mail: zdenek.skrott@upol.cz
Phone: +420 585632144
Curriculum Vitae: download here

Publications (Impact Factor Journals)

  • [4]
    ŠKROTT, Z., D. MAJERA, J. GURSKÝ, T. BUCHTOVÁ, M. HAJDÚCH, M. MISTRÍK a J. BÁRTEK. Disulfiram's anti-cancer activity reflects targeting NPL4, not inhibition of aldehyde dehydrogenase. Oncogene. 2019, 38(40), 6711-6722. ISSN 0950-9232. IF: 6.634. PMID: 31391554
  • [3]
    MAJERA, D., Z. ŠKROTT, J. BOUCHAL, J. BARTKOVA, D. ŠIMKOVÁ, M. GACHECHILADZE, J. STEIGEROVÁ, D. KURFÜRSTOVÁ, J. GURSKÝ, G. KOŘÍNKOVÁ, K. CWIERTKA, Z. HODNY, M. MISTRÍK a J. BÁRTEK. Targeting genotoxic and proteotoxic stress-response pathways in human prostate cancer by clinically available PARP inhibitors, vorinostat and disulfiram. The Prostate. 2018, 79(4), 352-362. ISSN 0270-4137. IF: 3.347. PMID: 30499118
  • [2]
    ŠKROTT, Z., M. MISTRÍK, K. ANDERSEN, S. FRIIS, D. MAJERA, J. GURSKÝ, T. OŽDIAN, J. BARTKOVA, Z. TURI, P. MOUDRÝ, M. KRAUS, M. MEDVEDÍKOVÁ, J. VÁCLAVKOVÁ, P. DŽUBÁK, I. VROBEL, P. POUCKOVA, J. SEDLACEK, A. MIKLOVICOVA, A. KUTT, J. MATTOVA, C. DRIESSEN, Q. DOU, J. OLSEN, M. HAJDÚCH, B. CVEK, R. DESHAIES a J. BÁRTEK. Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4. Nature. 2017, 552(7684), 194-199. ISSN 0028-0836. IF: 40.137. PMID: 29211715
  • [1]
    CHROMÁ, K., M. MISTRÍK, P. MOUDRÝ, J. GURSKÝ, M. LIPTAY, R. STRAUSS, Z. ŠKROTT, R. VRTEL, J. BARTKOVA, J. KRAMARA a J. BÁRTEK. Tumors overexpressing RNF168 show altered DNA repair and responses to genotoxic treatments, genomic instability and resistance to proteotoxic stress. Oncogene. 2017, 36(17), 2405-2422. ISSN 0950-9232 . IF: 7.932. PMID: 27841863

  • Patents, Utility models & other IP's :

    [1] BIOAVAILABLE DITHIOCARBAMATE-METAL COMPLEX NANOPARTICLES, METHOD OF PREPARATION AND USE THEREOF, EP 17193240.3
    1. Published Application EP 17193240.3 under EP 3459526 (27.3.2019)
    2. Published Application PCT/EP2018/076098 under WO 2019/063601

    Status: Available



    Master students mentor:

    [1] Zuzana Machačová, The role of the p97 / NPL4 protein complex in repairing damaged DNA,
    status: Ongoing, from: 2019


    Bachelor students mentor:

    [2] M. Kempná, Targeting NPL4 protein in cancer,
    status: Ongoing, from: 2019
    [1] Andrej Soos, Crosstalk between the ubiquitin proteasome system and genome integrity,
    status: Ongoing, from: 2016