Škrott Zdeněk Ph.D.

User picture
Phone: +420 585632144
Groups: IMTM, LIG, STAFF, SUPERVISOR

About me

Junior researcher in cellular biology and translational medicine, with ample experience in conducting and managing independent scientific projects. I am actively developing my own research program focused on the cellular response to proteotoxic stress and new techniques. 

Author of 16 original scientific publications with over 1000 SCI citations. H-index 11

Journals

LACEY, M., L. BÉRESOVÁ, A. SROVNALOVÁ, P. POLISHCHUK, M. SALA, Z. ŠKROTT, M. HAJDÚCH, P. DŽUBÁK, J. BÁRTEK, A. ŠIŠKOVÁ, M. LÖFFELMANN, R. NENCKA, M. MISTRÍK
Autophagy revealed as a targetable vulnerability in senescent cells by cell painting phenotypic profiling: a mechanistic study of MCOPPB and related compounds. Geroscience. 2026, ISSN: 2509-2723, PMID: 42062708,  PDF.
BÉRESOVÁ, L., J. VITECEK, I. PROTIVÁNKOVÁ, M. DUDKA, Z. ŠKROTT, T. BUCHTOVÁ, K. POLAKOVA, J. NOVOTNY, L. NOVAKOVA, J. BÁRTEK, M. MISTRÍK
Uncovering pre-cytokinetic block in cancer cells under shear stress using a disturbed flow-generating device. Scientific Reports. 2025, 15(1), 6457, ISSN: 2045-2322, PMID: 39987149,  PDF.
HUANG, J., J. CAMPIAN, T. DEWEES, Z. ŠKROTT, M. MISTRÍK, T. JOHANNS, G. ANSSTAS, O. BUTT, E. LEUTHARDT, G. DUNN, G. ZIPFEL, J. OSBUN, C. ABRAHAM, S. BADIYAN, K. SCHWETYE, J. CAIRNCROSS, J. RUBIN, A. KIM, M. GHEDA
A phase 1/2 study of disulfiram and copper with concurrent radiation therapy and temozolomide for patients with newly diagnosed glioblastoma. International Journal of Radiation Oncology, Biology, Physics. 2024, 120(3), 738-749, ISSN: 0360-3016, PMID: 38768767,

Books & book chapters

ŠKROTT, Z.
Methods for detection and induction of proteotoxic stress response in mammalian cells , 1.vyd., Olomouc, Palacky University, 2021, 23, 169-176, Dedication: LO1304, ISBN: 978-80-244-6049-9,

Intellectual property

MOLECULAR COMPLEX ASSEMBLY PARTICLES COMRISING BIS-R1, R2-DITHIOCARBAMATE-METAL COMPLEX AND A LIGAND, METHOD OF PREPARATION AND USE THEREOF - EP 18199181.1 (Mistrík) DISULFIRAM II
  1. Published Application EP 18199181.1 under EP 3636285 (15.4.2020)
  2. Published Application PCT/EP2019/077222 under WO 2020/074514 (16.4.2020)
  3. Patent: AU 2019358428. Granted: 17.11.2022. Ownership: Palacký University Olomouc. Inventors: MISTRÍK Martin, BÁRTEK Jiří, ŠKROTT Zdeněk, DŽUBÁK Petr, HAJDÚCH Marián
  4. Patent: CA 3,114,031. Granted: 12.3.2024. Ownership: Palacký University Olomouc. Inventors: MISTRÍK Martin, BÁRTEK Jiří, ŠKROTT Zdeněk, DŽUBÁK Petr, HAJDÚCH Marián
  5. Patent: IL 281616. Granted: 2.4.2024. Ownership: Palacký University Olomouc. Inventors: MISTRÍK Martin, BÁRTEK Jiří, ŠKROTT Zdeněk, DŽUBÁK Petr, HAJDÚCH Marián
  6. Patent: US 12,303,531. Granted: 20.5.2025. Ownership: Palacký University Olomouc. Inventors: MISTRÍK Martin, BÁRTEK Jiří, ŠKROTT Zdeněk, DŽUBÁK Petr, HAJDÚCH Marián
  7. Patent: JP 7220932. Granted: 3.2.2023. Ownership: Palacký University Olomouc. Inventors: MISTRÍK Martin, BÁRTEK Jiří, ŠKROTT Zdeněk, DŽUBÁK Petr, HAJDÚCH Marián
  8. Patent: BR 1120210061703. Granted: 18.2.2026. Ownership: Palacký University Olomouc. Inventors: MISTRÍK Martin, BÁRTEK Jiří, ŠKROTT Zdeněk, DŽUBÁK Petr, HAJDÚCH Marián
  9. Patent: MX 418,133. Granted: 29.10.2024. Ownership: Palacký University Olomouc. Inventors: MISTRÍK Martin, BÁRTEK Jiří, ŠKROTT Zdeněk, DŽUBÁK Petr, HAJDÚCH Marián
  10. Patent: KR 10-2626651. Granted: 17.1.2024. Ownership: Palacký University Olomouc. Inventors: MISTRÍK Martin, BÁRTEK Jiří, ŠKROTT Zdeněk, DŽUBÁK Petr, HAJDÚCH Marián

Status: Available

BIOAVAILABLE DITHIOCARBAMATE-METAL COMPLEX NANOPARTICLES, METHOD OF PREPARATION AND USE THEREOF - EP 17193240.3 (Škrott) DISULFIRAM I
  1. Patent: EP 3459526. Granted: 24.2.2021. Ownership: Palacký University Olomouc. Inventors: Škrott Zdeněk, Mistrík Martin, Hajdúch Marián, Bártek Jiří, Džubák Petr, Zbořil Radek.
  2. Published Application: PCT/EP2018/076098 under WO 2019/063601 (4.4.2019)
  3. Patent: US 11,766,404. Granted: 26.9.2023. Ownership: Palacký University Olomouc. Inventors: Škrott Zdeněk, Mistrík Martin, Hajdúch Marián, Bártek Jiří, Džubák Petr, Zbořil Radek.
  4. Patent: AU 2018340510. Granted: 5.8.2021. Ownership: Palacký University Olomouc. Inventors: Škrott Zdeněk, Mistrík Martin, Hajdúch Marián, Bártek Jiří, Džubák Petr, Zbořil Radek.
  5. Patent: IL 273652. Granted: 2.1.2024. Ownership: Palacký University Olomouc. Inventors: Škrott Zdeněk, Mistrík Martin, Hajdúch Marián, Bártek Jiří, Džubák Petr, Zbořil Radek.
  6. Patent: CA 3,076,855. Granted: 26.4.2022. Ownership: Palacký University Olomouc. Inventors: Škrott Zdeněk, Mistrík Martin, Hajdúch Marián, Bártek Jiří, Džubák Petr, Zbořil Radek.
  7. Patent: KR 10-2456683. Granted: 14.10.2022. Ownership: Palacký University Olomouc. Inventors: Škrott Zdeněk, Mistrík Martin, Hajdúch Marián, Bártek Jiří, Džubák Petr, Zbořil Radek.
  8. Patent: JP 7149624. Granted: 29.9.2022. Ownership: Palacký University Olomouc. Inventors: Škrott Zdeněk, Mistrík Martin, Hajdúch Marián, Bártek Jiří, Džubák Petr, Zbořil Radek.
  9. Patent: MX 396,552. Granted: 17.10.2022. Ownership: Palacký University Olomouc. Inventors: Škrott Zdeněk, Mistrík Martin, Hajdúch Marián, Bártek Jiří, Džubák Petr, Zbořil Radek.
  10. Patent:  BR 112020005823-8. Granted: 12.11.2024. Ownership: Palacký University Olomouc. Inventors: Škrott Zdeněk, Mistrík Martin, Hajdúch Marián, Bártek Jiří, Džubák Petr, Zbořil Radek.

Status: Available

Doctoral mentorship

Kiška Adam

Signaling DNA damage in cellular response to stress

Status: Ongoing from 2024.

Master mentorship

Machačová Zuzana M.Sc.

The role of the p97 / NPL4 protein complex in repairing damaged DNA

Status: Graduated from 2019 to 2021.

Löffelmann Martin

Identification of new inhibitors of NPL4 protein and insight into the mechanism of their action

Status: Graduated from 2020 to 2022.

Svobodová Natálie

Targeting heat shock proteins in cancer

Status: Graduated from 2023 to 2025.

Bachelor mentorship

Třeštík Jan

Targeting cell stress pathways in cancer

Status: Ongoing from 2024.

Soos Andrej

Crosstalk between the ubiquitin proteasome system and genome integrity

Status: Graduated from 2016 to 2017.

Kempná Magdalena

Targeting NPL4 protein in cancer

Status: Graduated from 2019 to 2020.

Open positions

1 Molecular and Translational Medicine
Project: Cellular stress in health and disease
Supervisors: Mistrík Martin Ph.D., Moudrý Pavel Ph.D., Škrott Zdeněk Ph.D.
Available: 3
Intended for: Doctoral training

WHERE TO FIND US

Hněvotínská 1333/5
779 00 Olomouc
Czech Republic

+420 585632111
+420 585632180
recepce.umtm@upol.cz
info@imtm.cz

GPS: 49° 35´ 10.1869512" N, 17° 14´ 6.292305" E

ABOUT IMTM

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