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Srovnal Josef M.D., Ph.D.

Impact factor journals

VECERA, L., P. PRASIL, J. SROVNAL, E. BERTA, M. VIDLAŘOVÁ, T. GABRHELIK, P. KOUŘILOVÁ, M. LOVEČEK, P. SKALICKÝ, J. ŠKARDA, Z. KALA, P. MICHALEK, M. HAJDÚCH
Morphine Analgesia, Cannabinoid Receptor 2, and Opioid Growth Factor Receptor Cancer Tissue Expression Improve Survival after Pancreatic Cancer Surgery. Cancers. 2023, 15(16), 4038, ISSN: 2072-6694, PMID: 37627066,
ŘEHULKOVÁ, A., J. CHUDÁČEK, A. PROKOPOVÁ, M. VIDLAŘOVÁ, J. STRÁNSKÁ, J. DRÁBEK, J. POTOČKOVÁ, R. TROJANEC, J. VRBKOVÁ, J. ŠKARDA, T. BOHANES, M. SZKORUPA, B. TOLMACI, J. KLEIN, J. SROVNAL, M. HAJDÚCH
Clinical and prognostic significance of detecting CEA, EGFR, LunX, c-met and EpCAM mRNA-positive cells in the peripheral blood, tumor-draining blood and bone marrow of non-small cell lung cancer patients. Translational Lung Cancer Research. 2023, 12(5), 1034-1050, ISSN: 2226-4477 , PMID: 37323172,
BERTA, E., J. SROVNAL, P. DYTRYCH, J. BRUTHANS, J. ULRICHOVÁ, P. PRASIL, L. VECERA, T. GABRHELIK, B. TOLMACI, J. DUSA, J. MACA, M. MAZACOVA, F. HAJDUK, M. KUTEJ, P. IHNAT, P. MICHALEK, M. HAJDÚCH
Influence of opioid analgesia type on circulating tumor cells in open colorectal cancer surgery (POACC-1): study protocol for a prospective randomized multicenter controlled trial. BMC Anesthesiology. 2023, 23(1), 64, ISSN: 1471-2253, PMID: 36855089,

Other reviewed journals

PRASIL, P., T. GABRHELIK, J. SROVNAL, L. VECERA, E. BERTA
Vliv opioidů na diseminaci nádorové choroby po chirurgickém výkonu. Bolest. 2019, 21(2), 52-57, ISSN: 1212-0634.
PRASIL, P., T. GABRHELIK, J. SROVNAL, L. VECERA, E. BERTA
Opioidy a perioperační ovlivnění imunitního systému. Bolest. 2018, 21(11), 21-26, ISSN: 1212-0634.
BÉBAROVÁ, L., P. SKALICKÝ, J. SROVNAL, A. PROKOPOVÁ, J. ZAPLETALOVÁ, M. HAJDÚCH, M. LOVECEK
The effect of circulating tumor cells on the survival of patients with pancreatic cancer − 5-year results. Rozhledy v chirurgii. 2018, 97(2), 94-98, ISSN: 0035-9351.

Books

Laboratory Techniques in Cellular and Molecular Medicine, 1.vyd., Olomouc, Palacky University, 2021, 436 s, Dedication: LO1304, ISBN: 978-80-244-6049-9,
BOUCHALOVÁ, K., M. HAJDÚCH, J. BOUCHAL, A. HLOBILKOVA, M. HOUDOVÁ MEGOVÁ, M. HUDCOVÁ, V. KOUDELÁKOVÁ, J. MEDALOVA, J. SROVNAL, R. TROJANEC
Prediktivní a prognostická onkologie, 1. vyd, Olomouc, Univerzita Palackého v Olomouci, 2016, 122 s, Dedication: CZ.1.07/2.3.00/09.0089, ISBN: 978-80-244-3188-8,
DRÁBEK, J., J. BERKOVCOVÁ, P. DŽUBÁK, M. HAJDÚCH, M. KHOYLOU, V. KOUDELÁKOVÁ, J. SROVNAL, M. STAŇKOVÁ, R. TROJANEC
Detekce nádorových biomarkerů v molekulárně biologické laboratoři, 1. vyd, Olomouc, Univerzita Palackého v Olomouci, 2012, 144 s, Dedication: MOLONKOL CZ.1.07/2.3.00/09.0089, ISBN: 978-80-244-3002-7,

Book chapters

CIBIČEK, N., J. VACEK, M. BERANEK, P. DŽUBÁK, Z. HEŘMANOVÁ, P. KOSINA, M. KUBALA, M. NOVÁK, B. PAPOUSKOVA, J. SROVNAL, J. VÁVROVÁ, J. VOSTALOVA, M. ZATLOUKALOVA, H. ŽIVNÁ
Hmotnostní spektrometrie, 1. vyd, Olomouc, Univerzita Palackého v Olomouci, 2014, 2.2, 34-40, ISBN: 978-80-244-3951-8,
CIBIČEK, N., J. VACEK, M. BERANEK, P. DŽUBÁK, Z. HEŘMANOVÁ, P. KOSINA, M. KUBALA, M. NOVÁK, B. PAPOUSKOVA, J. SROVNAL, J. VÁVROVÁ, J. VOSTALOVA, M. ZATLOUKALOVA, H. ŽIVNÁ
Elektrochemické metody, (bio)senzory a čipové platformy, 1. vyd, Olomouc, Univerzita Palackého v Olomouci, 2014, 2.3, 43-44, ISBN: 978-80-244-3951-8,
Onkogenetika, 1.vyd., Olomouc, Univerzita Palackého v Olomouci, 2018, 109-116, ISBN: 978-80-244-5368-2,

Intellectual property

Biomarker assay and uses thereof for diagnosis, therapy selection, and prognosis of cancer (Šurinová)
  1. Published Application PCT/EP2013/057111 under WO 2013/152989 (17.10.2013)

Status: Terminated

METHOD OF DETERMINATION OF CANCER CELL DRUG SENSITIVITY TOWARDS AURORA KINASE INHIBITORS AND OVERCOMIMG THEIR RESISTANCE (Madhu)
  1. Published Application PCT/CZ2012/000123 under WO 2013/083098 (13.6.2013)
  2. Patent: EP 2788504; Granted: 21.7.2016; Ownership: Palacky University Olomouc, Institute of Animal Physiology and Genetics CAS; Inventors: Kollaredy MadhusudhanHajdúch MariánDžubák PetrSrovnal JosefHrabáková, Kovářová Hana  
  3. Patent: JP 6144696; Granted: 19.5.2017; Ownership: Palacky University Olomouc, Institute of Animal Physiology and Genetics CAS; Inventors: Kollaredy Madhusudhan, Hajdúch MariánDžubák PetrSrovnal Josef, Hrabáková, Kovářová Hana
  4. Patent: CA 2.855.921; Granted: 5.3.2019; Ownership: Palacky University Olomouc, Institute of Animal Physiology and Genetics CAS; Inventors: Kollaredy Madhusudhan, Hajdúch MariánDžubák PetrSrovnal Josef, Hrabáková, Kovářová Hana
  5. Published Application US 2014/0336073 (13.11.2014)

Status: Terminated

Doctoral mentorship

Vidlařová Monika M.Sc.

Detection and clinical importance of circulating tumor cells in solid tumours

Status: Ongoing from 2014.
Řehulková Alona M.D.

Prognostic and predictive factors in solid tumors

Status: Ongoing from 2015.
Stejskal Pavel

Circulating tumor cells detection

Status: Ongoing from 2020.

Master mentorship

Kvapil Marek

Liquid colorectal cancer biopsy

Status: Ongoing from 2023.
Ondrouch Jakub B.Sc.

miRNA expression profiling in oesophageal disease

Status: Graduated from 2015 to 2015.
Juřicová Markéta

Mechanism of phenretinide action and effect on miRNA expression in cystic fibrosis models

Status: Graduated from 2019 to 2021.

Bachelor mentorship

Tinková Eva

MirRNA expression profiling in Barrett’s oesophagus

Status: Graduated from 2011 to 2015.
Horáková Kateřina

The RNA stability and degradation in the blood tubes

Status: Graduated from 2018 to 2020.
Svatošová Barbora

Detection of somatic mutations and selected cytogenetic changes in gliomas

Status: Graduated from 2021 to 2023.

Open positions

Project: Diagnostics and therapy of rare diseases
Supervisors: Hajdúch Marián M.D., Ph.D., Srovnal Josef M.D., Ph.D.
Available: 2
Intended for: Doctoral training
Summary: 2 places in full-time study
Project: New prognostic and predictive factors in solid tumors
Supervisors: Hajdúch Marián M.D., Ph.D., Srovnal Josef M.D., Ph.D.
Available: 3
Intended for: Doctoral training
Summary: 3 places in full-time or combined form of study
Project: New prognostic and predictive factors in solid tumors
Supervisors: Srovnal Josef M.D., Ph.D., Hajdúch Marián M.D., Ph.D.
Available: 2
Intended for: Doctoral training
Summary: Cancer is the second leading cause of death in the western countries. Early diagnosis and targeted therapy improve the therapeutic outcome. With the emergence of new biotechnologies, diagnosis can be made early and precisely, and the knowledge of tumor molecular genetics can identify the most appropriate therapy for a particular patient. The sensitivity of modern molecular methods makes it possible to characterize the tumor properties from sites remote from the primary tumor using patient's blood. The subject of the offered study program is the identification of new prognostic and predictive biomarkers of cancer using liquid biopsies. This is particularly the analysis of circulating tumor cells (CTCs), circulating free tumor DNA (ctDNA) and circulating miRNAs. The aim of the project is to further implement a liquid biopsy concept into the diagnosis and therapy monitoring of solid tumors, especially colorectal, breast, lung and CNS tumors. These include therapy response and resistance monitoring, identifying new therapeutic targets and estimating disease prognosis. The project will provide training in widely-used, transferable techniques, including circulation tumor cells capture system, digital droplet PCR, reverse-transcription qPCR, RNA-seq, single cell analyses, xenografts models and other multi-omics methods. We are looking for candidates with a background in Molecular Biology, Medicine, Cell Biology or a related area, who are enthusiastic about investigating novel approaches in cancer diagnostic that have significant potential for public health.
Project: Diagnosis and treatment of rare diseases
Supervisors: Hajdúch Marián M.D., Ph.D., Srovnal Josef M.D., Ph.D.
Available: 2
Intended for: Doctoral training
Project: New prognostic and predictive factors in solid tumors
Supervisors: Hajdúch Marián M.D., Ph.D., Srovnal Josef M.D., Ph.D., Koudeláková Vladimíra Ph.D.
Available: 3
Intended for: Doctoral training
Project: Liquid biopsies in experimental and clinical oncology
Supervisors: Srovnal Josef M.D., Ph.D., Koudeláková Vladimíra Ph.D.
Available: 2
Intended for: Doctoral training