Srovnal Josef M.D., Ph.D.

Phone: +420 585632137

Scientist and medical professional mainly involved in molecular and translational medicine (disease area paediatric, oncology and medical genetics). Experienced in project management and certification processes, involved as investigator in more than 10 national and international projects, co-founder of spin-off company focused on manufacturing of molecular diagnostics. 
Published more than >35 papers, >3books/chapters, >2 patents,  >220 oral/poster presentations, >500 SCI citations, H-index 10

Molecular and translational medicine
Pediatrics, Oncology and Medical Genetics
Circulating tumor cells detection
Molecular profilling of tumors
Prognostic, predictive and diagnostic biomarkers

Responsibility for transcriptomic sequencing, circulating tumor cells detection, PCR based methods, gene expression profiling, SNP and CNV arrays. Biostatistical analyses. Biomedical project coordinator. Quality manager (ISO 15189). Teaching and examination of students, tutor for Bc., MSc. and PhD. students.

Publications (Impact Factor Journals)

  • [23]
    CAPKOVA, P., J. SROVNAL, Z. CAPKOVA, K. ŠTAFFOVÁ, V. BECVAROVA, M. TRKOVA, K. ADAMOVA, A. ŠANTAVÁ, V. CURTISOVA, M. HAJDÚCH a M. PROCHAZKA. MLPA is a practical and complementary alternative to CMA for diagnostic testing in patients with autism spectrum disorders and identifying new candidate CNVs associated with autism. PeerJ. 2019, 6, e6183. ISSN 2167-8359. IF: 2.118. PMID: 30647996
  • [22]
    MEDKOVA, A., J. SROVNAL, J. POTOMKOVA, J. VOLEJNÍKOVÁ a V. MIHÁL. Multifarious diagnostic possibilities of the S100 protein family: predominantly in pediatrics and neonatology. World Journal of Pediatrics. 2018, 14(4), 315-321. ISSN 1708-8569. IF: 1.164. PMID: 29858979
  • [21]
    CAPKOVA, P., A. ŠANTAVÁ, I. MARKOVA, A. STEFEKOVA, J. SROVNAL, K. ŠTAFFOVÁ a V. DURDOVA. Haploinsufficiency of BMP4 and OTX2 in the Foetus with an abnormal facial profile detected in the first trimester of pregnancy. Molecular Cytogenetics. 2017, 10, 47. ISSN 1755-8166. IF: 1.455. PMID: 29299063
  • [20]
    HEZOVA, R., A. KOVARIKOVA, J. SROVNAL, M. ZEMANOVÁ, T. HARUSTIAK, J. EHRMANN, M. HAJDÚCH, M. SACHLOVA, M. SVOBODA a O. SLABÝ. MiR-205 functions as a tumor suppressor in adenocarcinoma and an oncogene in squamous cell carcinoma of esophagus. Tumor Biology. 2015, 37(6), 8007-18. ISSN 1010-4283 . IF: 2.926. PMID: 26711784
  • [19]
    VYLICILOVA, H., V. HUSICKOVA, L. SPICHAL, J. SROVNAL, K. DOLEZAL, O. PLIHAL a L. PLÍHALOVÁ. C2-substituted aromatic cytokinin sugar conjugates delay the onset of senescence by maintaining the activity of the photosynthetic apparatus. Phytochemistry. 2015, 122(-), 22-33. ISSN 0031-9422. IF: 2.779. PMID: 26706318
  • [18]
    SURINOVA, S., M. CHOI, S. TAO, P.J. SCHÜFFLER, C.Y.. CHANG, T. CLOUGH, K. VYSLOUŽIL, M. KHOYLOU, J. SROVNAL, Y. LIU, M. MATONDO, R. HÜTTENHAIN, H. WEISSER, J.M. BUHMANN, M. HAJDÚCH, H. BRENNER, O. VITEK a R. AEBERSOLD. Prediction of colorectal cancer diagnosis based on circulating plasma proteins. EMBO Molecular Medicine. 2015, 7(9), 1166-1178. ISSN 1757-4676 . IF: 9.547. PMID: 26253081
  • [17]
    SURINOVA, S., L. RADOVÁ, M. CHOI, J. SROVNAL, H. BRENNER, O. VITEK, M. HAJDÚCH a R. AEBERSOLD. Non-invasive prognostic protein biomarker signatures associated with colorectal cancer. EMBO Molecular Medicine. 2015, 7(9), 1153-1165. ISSN 1757-4676. IF: 9.547. PMID: 26253080
  • [16]
    HEZOVA, R., A. KOVARIKOVA, J. SROVNAL, M. ZEMANOVÁ, T. HARUSTIAK, J. EHRMANN, M. HAJDÚCH, M. SVOBODA, M. SACHLOVA a O. SLABÝ. Diagnostic and prognostic potential of miR-21, miR-29c, miR-148 and miR-203 in adenocarcinoma and squamous cell carcinoma of esophagus. Diagnostic Pathology. 2015, 10(-), Article Number: 42. ISSN 1746-1596. IF: 1.895. PMID: 25928282
  • [15]
    SLABÝ, O., J. SROVNAL, L. RADOVÁ, J. GREGAR, J. JURACEK, P. LUŽNÁ, M. SVOBODA, M. HAJDÚCH a J. EHRMANN. Dynamic changes in microRNA expression profiles reflect progression of Barrett's esophagus to esophageal adenocarcinoma. Carcinogenesis. 2015, 36(5), 521-527. ISSN 0143-3334. IF: 4.874. PMID: 25784377
  • [14]
    TRIZULJAK, J., J. SROVNAL, K. PLEVOVA, Y. BRYCHTOVA, L. SEMERAD, D. BAKEŠOVÁ, E. LETALOVA, A. BENEDÍKOVÁ, J. MAYER, M. HAJDÚCH, S. POSPISILOVA a M. DOUBEK. Analysis of Prognostic Significance of Merkel Cell Polyomavirus in Chronic Lymphocytic Leukemia. Clinical Lymphoma Myeloma & Leukemia. 2015, 15(7), 439-442. ISSN 2152-2669. IF: 2.316. PMID: 25758600
  • [13]
    RANC, V., J. SROVNAL, L. KVÍTEK a M. HAJDÚCH. Discrimination of circulating tumor cells of breast cancer and colorectal cancer from normal human mononuclear cells using Raman spectroscopy. Analyst. 2013, 138(20), 5983-5988. ISSN 0003-2654. IF: 3.906. PMID: 23945652
  • [12]
    CHUDÁČEK, J., T. BOHANES, J. KLEIN, A. BENEDÍKOVÁ, J. SROVNAL, M. SZKORUPA, P. SKALICKÝ, J. ŠKARDA, M. HAJDÚCH a C. NEORAL. Detection of minimal residual disease in lung cancer. Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czech Republic. 2014, 158(2), 189-193. ISSN 1213-8118. IF: 1.200. PMID: 23558472
  • [11]
    BALIK, V., J. SROVNAL, I. SULLA, O. KALITA, T. FOLTANOVÁ, M. VAVERKA, L. HRABALEK a M. HAJDÚCH. MEG3: a novel long noncoding potentially tumour-suppressing RNA in meningiomas. Journal of Neuro-Oncology. 2013, 112(1), 1-8. ISSN 0167-594X. IF: 2.787. PMID: 23307326
  • [10]
    SPENEROVA, M., P. DŽUBÁK, J. SROVNAL, L. RADOVÁ, R. BURIÁNOVÁ, P. KONEČNÝ, S. ŠÁLKOVÁ, Z. NOVÁK, D. POSPÍŠILOVÁ, J. STARÝ, B.. BLAZEK, J. HAK, T. VOTAVA, P. TIMR, E. KAISEROVA, E. BUBANSKA, V. MIHÁL a M. HAJDÚCH. Combination of prednisolone and low dosed dexamethasone exhibits greater in vitro antileukemic activity than equiactive dose of prednisolone and overcomes prednisolone drug resistence in acute childhood lymphoblastic leukemia. Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czech Republic. 2014, 158(3), 422-427. ISSN 1213-8118. IF: 1.200. PMID: 23128824
  • [9]
    HAVLÍK, R., J. SROVNAL, D. KLOS, A. BENEDÍKOVÁ, M. LOVEČEK, M. GHOTHIM, D. CAHOVÁ, C. NEORAL a M. HAJDÚCH. Occult tumour cells in peritoneal lavage are a negative prognostic factor in pancreatic cancer. Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czech Republic. 2013, 157(3), 233-238. ISSN 1213-8118. IF: 1.661. PMID: 23128819
  • [8]
    SMILEK, P., J. NEUWIRTHOVA, J. JARKOVSKÝ, L. DUŠEK, J. ROTTENBERG, R. KOSTŘICA, J. SROVNAL, M. HAJDÚCH, J. DRÁBEK a J. KLOZAR. Epidermal growth factor receptor (EGFR) expression and mutations in the EGFR signaling pathway in correlation with anti-EGFR therapy in head and neck squamous cell carcinomas. Neoplasma. 2012, 59(5), 508-515. ISSN 0028-2685. IF: 1.547. PMID: 22668015
  • [7]
    KREJCI, K., T. TICHÝ, P. HORAK, H. CIFERSKA, M. HAJDÚCH, J. SROVNAL, R. TROJANEC, M. ZEZULOVÁ, M. ZLEVOROVA, L. KALINOVA a J. ZADRAZIL. Merkel Cell Carcinoma of the Gluteal region with Ipsilateral Metastasi into the Pancreatic Graft of Patient after Combined Kidney-Pancreas Transplantation. Onkologie. 2010, 33(-), 520-524. ISSN 0378-584X. IF: 1.156. PMID: 20926899
  • [6]
    JANKU, F., J. SROVNAL, G. KOŘÍNKOVÁ, J. NOVOTNY, L. PETRUZELKA, D. POWER, B. MATOUS a M. HAJDÚCH. Molecular detection of disseminated breast cancer cells in the bone marrow of early breast cancer patients using quantitative RT PCR for CEA. Neoplasma. 2008, 55(4), 317-322. ISSN 0028-2685. IF: 1.208. PMID: 18505343
  • [5]
    TURASHVILI, G., J. BOUCHAL, K. BAUMFORTH, W. WEI, M. DZIECHCIARKOVA, J. EHRMANN, J. KLEIN, E. FRIDMAN, J. ŠKARDA, J. SROVNAL, M. HAJDÚCH, P. MURRAY a Z. KOLÁŘ. Novel markers for differentiation of lobular and ductal invasive breast carcinomas by laser microdissection and microarray analysis. BMC Cancer. 2007, 7(55), -. ISSN 1471-2407. IF: 2.359. PMID: 17389037
  • [4]
    KRYŠTOF, V., P. CANKAR, I. FRYŠOVÁ, J. SLOUKA, G. KONTOPIDIS, P. DŽUBÁK, M. HAJDÚCH, J. SROVNAL, W.F. DE AZAVEDO, M. ORSÁG, M. PAPRSKÁŘOVÁ, J. ROLČÍK, A. LÁTR, P.M. FISCHER a M. STRNAD. 4-Arylazo-3,5-diamino-1H-pyrazole CDK Inhibitors: SAR Study, Crystal Structure in Complex with CDK2, Selectivity, and Cellular Effects. Journal of Medicinal Chemistry. 2006, 49(22), 6500-6509. ISSN 0022-2623. IF: 4.926. PMID: 17064068
  • [3]
    POTĚŠIL, J., F. KOPŘIVA, P. DŽUBÁK, M. GODOVA, L. RADOVÁ, J. SROVNAL, V. MIHÁL a M. HAJDÚCH. Expression of multidrug resistance protein 1 and multidrug resistance-associated protein 1 in peripheral blood lymphocytes amongst children and young adults. Central European Journal of Immunology. 2013, 38(4), 518-529. ISSN 1426-3912. IF: 0.358.
  • [2]
    CHALOUPKOVA, Z., A. BALZEROVA, Z. MEDRIKOVA, J. SROVNAL, M. HAJDÚCH, K. CEPE, V. RANC a R. ZBOŘIL. Label-free determination and multiplex analysis of DNA and RNA in tumor tissues. Applied Materials Today. 2018, 12(2018), 85-91. ISSN 2352-9407. IF: 1.691.
  • [1]
    CAPKOVA, Z., P. CAPKOVA, J. SROVNAL, K. ŠTAFFOVÁ, V. BECVAROVA, M. TRTKOVA, K. ADAMOVA, A. ŠANTAVÁ, V. CURTISOVA, M. HAJDÚCH a M. PROCHAZKA. Differences in the importance of microcephaly, dysmorphism, and epilepsy in the detection of pathogenic CNVs in ID and ASD patients. PeerJ. 2019, 7, e7979. ISSN 2167-8359. IF: 2.353.
  • Publications (Other Reviewed Journals)

  • [8]
    PRASIL, P., T. GABRHELIK, J. SROVNAL, L. VECERA a E. BERTA. Vliv opioidů na diseminaci nádorové choroby po chirurgickém výkonu. Bolest. 2019, 21(2), 52-57. ISSN 1212-0634.
  • [7]
    BÉBAROVÁ, L., P. SKALICKÝ, J. SROVNAL, A. PROKOPOVÁ, J. ZAPLETALOVÁ, M. HAJDÚCH a M. LOVECEK. The effect of circulating tumor cells on the survival of patients with pancreatic cancer − 5-year results. Rozhledy v chirurgii. 2018, 97(2), 94-98. ISSN 0035-9351.
  • [6]
    PRASIL, P., T. GABRHELIK, J. SROVNAL, L. VECERA a E. BERTA. Opioidy a perioperační ovlivnění imunitního systému. Bolest. 2018, 21(11), 21-26. ISSN 1212-0634.
  • [5]
    GHOTHIM, M., J. SROVNAL, L. BÉBAROVÁ, J. TESAŘÍKOVÁ, P. SKALICKÝ, D. KLOS, A. PROKOPOVÁ, M. VAHALÍKOVÁ, H. SLAVÍK, J. VRBKOVÁ, C. NEORAL, R. HAVLÍK, M. HAJDÚCH a M. LOVEČEK. Determination of CEA, EGFR and hTERT expression in peritoneal lavage in patients with pancreatic adenocarcinoma using RT - PCR method. Rozhledy v chirurgii. 2015, 94(11), 464-9. ISSN 0035-9351 . PMID: 26 766 154
  • [4]
    SPENEROVA, M., J. SROVNAL, J. POTĚŠIL, M. HAJDÚCH, V. MIHÁL a P. DŽUBÁK. Historie glukokortikoidní terapie v léčbě akutních leukémií u dětí. Česko-slovenská pediatrie. 2014, 69(6), 350-362. ISSN 0069-2328.
  • [3]
    KOVARIKOVA, A., R. HEZOVA, J. SROVNAL, M. REDOVA a O. SLABÝ. Role mikroRNA v molekulární patologii karinomu jícnu a jejich potenciální využití v klinické onkologii. Klinická onkologie. 2014, 27(2), 87-86. ISSN 0862-495X.
  • [2]
    NEUWIRTHOVA, J., P. SMILEK, J. JARKOVSKÝ, L. DUŠEK, J. ROTTENBERG, R. KOSTŘICA, J. SROVNAL, M. HAJDÚCH, J. DRÁBEK, J. KLOZAR a R. CERVENA. Sledování mutace KRAS při léčbě cetuximabem u spinocelulárních karcinomů hlavy a krku. Remedia. 2012, 22(3), 231-234. ISSN 0862-8947.
  • [1]
    BENEDÍKOVÁ, A., J. SROVNAL, M. SZKORUPA, P. SKALICKÝ, J. CHUDÁČEK, T. BOHANES, J. ŠKARDA, Z. KOLÁŘ, M. HAJDÚCH a J. KLEIN. Biomarkery detekce minimální systémové diseminace u nemocných s karcinomem plic. Rozhledy v chirurgii. 2012, 91(4), 209-215. ISSN 0035-9531.

  • Patents, Utility models & other IP's :

    1. Published Application PCT/CZ2012/000123 under WO 2013/083098 (publ. 13. 6. 2013)
    2. Patent: EP 2788504, Granted: 21. 7. 2016, Ownership: Palacky University Olomouc, Institute of Animal Physiology and Genetics CAS, Inventors: Kollaredy MadhusudhanHajdúch MariánDžubák PetrSrovnal JosefHrabáková, Kovářová Hana  
    3. Patent: JP 6144696, Granted: 19. 5. 2017, Ownership: Palacky University Olomouc, Institute of Animal Physiology and Genetics CAS, Inventors: Kollaredy Madhusudhan, Hajdúch MariánDžubák PetrSrovnal Josef, Hrabáková, Kovářová Hana
    4. Patent: CA 2855921, Granted: 5. 3. 2019, Ownership: Palacky University Olomouc, Institute of Animal Physiology and Genetics CAS, Inventors: Kollaredy Madhusudhan, Hajdúch MariánDžubák PetrSrovnal Josef, Hrabáková, Kovářová Hana

    Status: Available

    Doctoral students mentor:

    [3] Alona Řehulková, Prognostic and predictive factors in solid tumors,
    Ph.D. specialization: , status: Ongoing, from: 2015
    [2] Hanuš Slavík, Minimal residual disease in solid cancers,
    Ph.D. specialization: , status: Ongoing, from: 2014
    [1] Monika Vidlařová, Detection and clinical importance of circulating tumor cells in solid tumours,
    Ph.D. specialization: , status: Ongoing, from: 2014

    Master students mentor:

    [4] Markéta Juřicová, Mechanism of phenretinide action and effect on miRNA expression in cystic fibrosis models,
    status: Ongoing, from: 2019
    [3] Jakub Ondrouch, miRNA expression profiling in oesophageal disease,
    status: Graduated, from: 2015
    [2] Zuzana Bačová, Gene expression profiling in hematological malignancies,
    status: Graduated, from: 2013 to 2015
    [1] Hanuš Slavík, Effect of analgesia on circulating tumor cells levels in colorectal cancer patients,
    status: Graduated, from: 2012 to 2014

    Bachelor students mentor:

    [3] Kateřina Horáková, The RNA stability and degradation in the blood tubes,
    status: Ongoing, from: 2018
    [2] Kateřina Hošková, Chromosomal aberations analysis in children with autistic spectrum disorders,
    status: Ongoing, from: 2016
    [1] Eva Tinková, MirRNA expression profiling in Barrett’s oesophagus ,
    status: Graduated, from: 2011 to 2015