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Srovnal Josef M.D., Ph.D.
About me
Scientist and medical professional mainly involved in molecular and translational medicine (disease area paediatric, oncology and medical genetics). Experienced in project management and certification processes, involved as investigator in more than 20 national and international projects, co-founder of spin-off company focused on manufacturing of molecular diagnostics.
Published more than >45 papers, >4books/chapters, >2 patents, >260 oral/poster presentations, >710 SCI citations, H-index 11
Specialties:
Molecular and translational medicine
Pediatrics, Oncology and Medical Genetics
Circulating tumor cells detection
Molecular profilling of tumors
Prognostic, predictive and diagnostic biomarkers
Responsibility for transcriptomic sequencing, circulating tumor cells detection, PCR based methods, gene expression profiling, SNP and CNV arrays. Biostatistical analyses. Biomedical project coordinator. Quality manager (ISO 15189). Teaching and examination of students, tutor for Bc., MSc. and PhD. students.
Impact factor journals
Morphine Analgesia, Cannabinoid Receptor 2, and Opioid Growth Factor Receptor Cancer Tissue Expression Improve Survival after Pancreatic Cancer Surgery.
Cancers.
2023,
15(16),
4038,
ISSN: 2072-6694,
PMID: 37627066,
Clinical and prognostic significance of detecting CEA, EGFR, LunX, c-met and EpCAM mRNA-positive cells in the peripheral blood, tumor-draining blood and bone marrow of non-small cell lung cancer patients.
Translational Lung Cancer Research.
2023,
12(5),
1034-1050,
ISSN: 2226-4477 ,
PMID: 37323172,
Influence of opioid analgesia type on circulating tumor cells in open colorectal cancer surgery (POACC-1): study protocol for a prospective randomized multicenter controlled trial.
BMC Anesthesiology.
2023,
23(1),
64,
ISSN: 1471-2253,
PMID: 36855089,
Other reviewed journals
Vliv opioidů na diseminaci nádorové choroby po chirurgickém výkonu.
Bolest.
2019,
21(2),
52-57,
ISSN: 1212-0634.
Opioidy a perioperační ovlivnění imunitního systému.
Bolest.
2018,
21(11),
21-26,
ISSN: 1212-0634.
The effect of circulating tumor cells on the survival of patients with pancreatic cancer − 5-year results.
Rozhledy v chirurgii.
2018,
97(2),
94-98,
ISSN: 0035-9351.
Books
Laboratory Techniques in Cellular and Molecular Medicine,
1.vyd.,
Olomouc,
Palacky University,
2021,
436 s,
Dedication: LO1304,
ISBN: 978-80-244-6049-9,
Prediktivní a prognostická onkologie,
1. vyd,
Olomouc,
Univerzita Palackého v Olomouci,
2016,
122 s,
Dedication: CZ.1.07/2.3.00/09.0089,
ISBN: 978-80-244-3188-8,
Detekce nádorových biomarkerů v molekulárně biologické laboratoři,
1. vyd,
Olomouc,
Univerzita Palackého v Olomouci,
2012,
144 s,
Dedication: MOLONKOL CZ.1.07/2.3.00/09.0089,
ISBN: 978-80-244-3002-7,
Book chapters
Hmotnostní spektrometrie,
1. vyd,
Olomouc,
Univerzita Palackého v Olomouci,
2014,
2.2,
34-40,
ISBN: 978-80-244-3951-8,
Elektrochemické metody, (bio)senzory a čipové platformy,
1. vyd,
Olomouc,
Univerzita Palackého v Olomouci,
2014,
2.3,
43-44,
ISBN: 978-80-244-3951-8,
Onkogenetika,
1.vyd.,
Olomouc,
Univerzita Palackého v Olomouci,
2018,
109-116,
ISBN: 978-80-244-5368-2,
Intellectual property
Biomarker assay and uses thereof for diagnosis, therapy selection, and prognosis of cancer (Šurinová)
- Published Application PCT/EP2013/057111 under WO 2013/152989 (17.10.2013)
Status: Terminated
METHOD OF DETERMINATION OF CANCER CELL DRUG SENSITIVITY TOWARDS AURORA KINASE INHIBITORS AND OVERCOMIMG THEIR RESISTANCE (Madhu)
- Published Application PCT/CZ2012/000123 under WO 2013/083098 (13.6.2013)
- Patent: EP 2788504; Granted: 21.7.2016; Ownership: Palacky University Olomouc, Institute of Animal Physiology and Genetics CAS; Inventors: Kollaredy Madhusudhan, Hajdúch Marián, Džubák Petr, Srovnal Josef, Hrabáková, Kovářová Hana
- Patent: JP 6144696; Granted: 19.5.2017; Ownership: Palacky University Olomouc, Institute of Animal Physiology and Genetics CAS; Inventors: Kollaredy Madhusudhan, Hajdúch Marián, Džubák Petr, Srovnal Josef, Hrabáková, Kovářová Hana
- Patent: CA 2.855.921; Granted: 5.3.2019; Ownership: Palacky University Olomouc, Institute of Animal Physiology and Genetics CAS; Inventors: Kollaredy Madhusudhan, Hajdúch Marián, Džubák Petr, Srovnal Josef, Hrabáková, Kovářová Hana
- Published Application US 2014/0336073 (13.11.2014)
Status: Terminated
Doctoral mentorship
Vidlařová Monika M.Sc.
Detection and clinical importance of circulating tumor cells in solid tumours
Status:
Ongoing from 2014.
Master mentorship
Ondrouch Jakub B.Sc.
miRNA expression profiling in oesophageal disease
Status:
Graduated from 2015 to 2015.
Juřicová Markéta
Mechanism of phenretinide action and effect on miRNA expression in cystic fibrosis models
Status:
Graduated from 2019 to 2021.
Bachelor mentorship
Tinková Eva
MirRNA expression profiling in Barrett’s oesophagus
Status:
Graduated from 2011 to 2015.
Horáková Kateřina
The RNA stability and degradation in the blood tubes
Status:
Graduated from 2018 to 2020.
Svatošová Barbora
Detection of somatic mutations and selected cytogenetic changes in gliomas
Status:
Graduated from 2021 to 2023.
Open positions
| Project: | Diagnostics and therapy of rare diseases |
|---|---|
| Supervisors: | Hajdúch Marián M.D., Ph.D., Srovnal Josef M.D., Ph.D. |
| Available: | 2 |
| Intended for: | Doctoral training |
| Summary: | 2 places in full-time study |
| Project: | New prognostic and predictive factors in solid tumors |
|---|---|
| Supervisors: | Hajdúch Marián M.D., Ph.D., Srovnal Josef M.D., Ph.D. |
| Available: | 3 |
| Intended for: | Doctoral training |
| Summary: | 3 places in full-time or combined form of study |
| Project: | New prognostic and predictive factors in solid tumors |
|---|---|
| Supervisors: | Srovnal Josef M.D., Ph.D., Hajdúch Marián M.D., Ph.D. |
| Available: | 2 |
| Intended for: | Doctoral training |
| Summary: | Cancer is the second leading cause of death in the western countries. Early diagnosis and targeted therapy improve the therapeutic outcome. With the emergence of new biotechnologies, diagnosis can be made early and precisely, and the knowledge of tumor molecular genetics can identify the most appropriate therapy for a particular patient. The sensitivity of modern molecular methods makes it possible to characterize the tumor properties from sites remote from the primary tumor using patient's blood. The subject of the offered study program is the identification of new prognostic and predictive biomarkers of cancer using liquid biopsies. This is particularly the analysis of circulating tumor cells (CTCs), circulating free tumor DNA (ctDNA) and circulating miRNAs. The aim of the project is to further implement a liquid biopsy concept into the diagnosis and therapy monitoring of solid tumors, especially colorectal, breast, lung and CNS tumors. These include therapy response and resistance monitoring, identifying new therapeutic targets and estimating disease prognosis. The project will provide training in widely-used, transferable techniques, including circulation tumor cells capture system, digital droplet PCR, reverse-transcription qPCR, RNA-seq, single cell analyses, xenografts models and other multi-omics methods. We are looking for candidates with a background in Molecular Biology, Medicine, Cell Biology or a related area, who are enthusiastic about investigating novel approaches in cancer diagnostic that have significant potential for public health. |
| Project: | Diagnosis and treatment of rare diseases |
|---|---|
| Supervisors: | Hajdúch Marián M.D., Ph.D., Srovnal Josef M.D., Ph.D. |
| Available: | 2 |
| Intended for: | Doctoral training |
| Project: | New prognostic and predictive factors in solid tumors |
|---|---|
| Supervisors: | Hajdúch Marián M.D., Ph.D., Srovnal Josef M.D., Ph.D., Koudeláková Vladimíra Ph.D. |
| Available: | 3 |
| Intended for: | Doctoral training |
| Project: | Liquid biopsies in experimental and clinical oncology |
|---|---|
| Supervisors: | Srovnal Josef M.D., Ph.D., Koudeláková Vladimíra Ph.D. |
| Available: | 2 |
| Intended for: | Doctoral training |