Adam Tomáš Ph.D.

Phone: +420 588444231, +420 585632152

Publications (Impact Factor Journals)

  • [37]
    KOUŘIL, ?.., J. DE SOUSA, J. VÁCLAVÍK, D. FRIEDECKÝ a T. ADAM. CROP: Correlation-based reduction of feature multiplicities in untargeted metabolomic data. Bioinformatics (Oxford, England). 2020, -, -. ISSN 1367-4803. IF: 4.531. PMID: 31930393
  • [36]
    DE SOUSA, J., O. VENCALEK, K. HRON, J. VÁCLAVÍK, D. FRIEDECKÝ a T. ADAM. Bayesian multiple hypotheses testing in compositional analysis of untargeted metabolomic data. Analytica Chimica Acta. 2020, 1097, 49-61. ISSN 0003-2670. IF: 5.256. PMID: 31910969
  • [35]
    JÁČOVÁ, J., M. JORENEK, K. POSPISKOVA, L. NAJDEKR, L. ZAJONCOVA, D. FRIEDECKÝ a T. ADAM. Urease-immobilized magnetic microparticles in urine sample preparation for metabolomic analysis by gas chromatography-mass spectrometry. Journal of Chromatography. A. 2019, 1605, 360355. ISSN 0021-967. IF: 3.858. PMID: 31315811
  • [34]
    MÁDROVÁ, L., M. KRIJT, V. BARESOVA, J. VÁCLAVÍK, D. FRIEDECKÝ, D. DOBEŠOVÁ, O. SOUCKOVA, V. SKOPKOVA, T. ADAM a M. ZIKANOVA. Mass spectrometric analysis of purine de novo biosynthesis intermediates. PLOS One. 2018, 13(12), e0208947. ISSN 1932-6203. IF: 2.766. PMID: 30532129
  • [33]
    KARLÍKOVÁ, R., J. ŠIROKÁ, M. MECH, D. FRIEDECKÝ, H. JANEČKOVÁ, L. MÁDROVÁ, F. HRDINOVA, Z. DRABKOVA, O. DOBESOVA, T. ADAM a P. JAHN. Newborn foal with atypical myopathy. Journal of Veterinary Internal Medicine. 2018, 32(5), 1768-1772. ISSN 0891-6640. IF: 2.185. PMID: 30216546
  • [32]
    VÁCLAVÍK, J., K. COENE, I. VROBEL, L. NAJDEKR, D. FRIEDECKÝ, R. KARLÍKOVÁ, L. MÁDROVÁ, A. PETSALO, U. ENGELKE, A. VAN WEGBERG, L. KLUIJTMANS, T. ADAM a R. WEVERS. Structural elucidation of novel biomarkers of known metabolic disorders based on multistage fragmentation mass spectra. Journal of Inherited Metabolic Disease. 2018, 41(3), 407-414. ISSN 0141-8955. IF: 3.970. PMID: 29139026
  • [31]
    KARLÍKOVÁ, R., K. MIČOVÁ, L. NAJDEKR, A. GARDLO, T. ADAM, P. MAJEROVÁ, D. FRIEDECKÝ a A. KOVAC. Metabolic status of CSF distinguishes rats with tauopathy from controls. Alzheimer's Research & Therapy. 2017, 9(1), 78. ISSN 1758-9193. IF: 6.154. PMID: 28934963
  • [30]
    CAMATEROS, P., C. KANAGARATHAM, L. NAJDEKR, D. HOLUB, J. VRBKOVÁ, L. COTE, J. FOURNIER, J. GOURDON, D. CREERY, R. OLIVENSTEIN, F. KOPŘIVA, T. ADAM, D. FRIEDECKÝ, P. DŽUBÁK, M. HAJDÚCH a D. RADZIOCH. Toll-Like Receptor 7/8 Ligand, S28463, Suppresses Ascaris Suum Induced Allergic Asthma in Nonhuman Primates. American Journal of Respiratory Cell and Molecular Biology. 2018, 58(1), 55-65. ISSN 1044-1549. IF: 4.100. PMID: 28850259
  • [29]
    JÁČOVÁ, J., A. GARDLO, D. FRIEDECKÝ, T. ADAM a J. DIMANDJA. Sample-independent approach to normalize two-dimensional data for orthogonality evaluation using whole separation space scaling. Journal of Chromatography. A. 2017, 1511(2017), 1-8. ISSN 0021-9673. IF: 3.981. PMID: 28693825
  • [28]
    VROBEL, I., D. FRIEDECKÝ, E. FABER, L. NAJDEKR, K. MIČOVÁ, R. KARLÍKOVÁ a T. ADAM. Novel sulphur-containing imatinib metabolites found by untargeted LC-HRMS analysis. European Journal of Pharmaceutical Sciences. 2017, -, -. ISSN 0928-0987. IF: 3.773. PMID: 28433749
  • [27]
    NAJDEKR, L., D. FRIEDECKÝ, R. TAUTENHAHN, T. PLUSKAL, J. WANG, Y. HUANG a T. ADAM. Influence of Mass Resolving Power in Orbital Ion-Trap Mass Spectrometry-Based Metabolomics. Analytical Chemistry. 2016, 88(23), 11429-11435. ISSN 0003-2700. IF: 6.320. PMID: 27809493
  • [26]
    KARLÍKOVÁ, R., J. ŠIROKÁ, P. JAHN, D. FRIEDECKÝ, A. GARDLO, H. JANEČKOVÁ, F. HRDINOVA, Z. DRABKOVA a T. ADAM. Equine atypical myopathy: A metabolic study. Veterinary Journal. 2016, 216(2016), 125-132. ISSN 1090-0233. IF: 1.802. PMID: 27687939
  • [25]
    KARLÍKOVÁ, R., J. ŠIROKÁ, D. FRIEDECKÝ, E. FABER, M. HRDA, K. MIČOVÁ, I. FIKAROVA, A. GARDLO, H. JANEČKOVÁ, I. VROBEL a T. ADAM. Metabolite Profiling of the Plasma and Leukocytes of Chronic Myeloid Leukemia Patients. Journal of Proteome Research. 2016, 15(9), 3158-66. ISSN 1535-3893 . IF: 4.268. PMID: 27465658
  • [24]
    VROBEL, I., H. JANEČKOVÁ, E. FABER, K. BOUCHALOVÁ, K. MIČOVÁ, D. FRIEDECKÝ a T. ADAM. Ultrafast Online SPE-MS/MS Method for Quantification of 3 Tyrosine Kinase Inhibitors in Human Plasma. Therapeutic Drug Monitoring. 2016, 38(4), 516-524. ISSN 0163-4356 . IF: 2.178. PMID: 27414975
  • [23]
    ŠTUDENTOVÁ, H., J. INDRAKOVA, P. PETROVA, M. KAMINEK, H. KALÁBOVÁ, V. ŠRÁMEK, T. ADAM a B. MELICHAR. Risk factors of atherosclerosis during systemic therapy targeting vascular endothelial growth factor. Oncology Letters . 2015, 11(2), 939-944. ISSN 1792-1074. IF: 1.482. PMID: 26893672
  • [22]
    LIGASOVÁ, A., R. LIBOSKA, D. FRIEDECKÝ, K. MIČOVÁ, T. ADAM, T. OŽDIAN, I. ROSENBERG a K. KOBERNA. Dr Jekyll and Mr Hyde: A Strange Case of 5-Ethynyl-2'-deoxyuridine and 5-ethynyl-2'-deoxycytidine. Open Biology. 2016, 6: 150172, 1-11. ISSN 2046-2441. IF: 3.481. PMID: 26740587
  • [21]
    ZEZULOVÁ, M., M. BARTOUŠKOVÁ, E. HLIDKOVA, J. JURANOVA, B. CERVINKOVA, E. KASALOVA, T. ADAM, L. KUJOVSKA KRCMOVA, D. SOLICHOVA, K. CWIERTKA, D. VRÁNA a B. MELICHAR. Prognostic significance of serum and urinary neopterin concentrations in patients with rectal carcinoma treated with chemoradiation. Anticancer Research . 2016, 36(1), 287-292. ISSN 0250-7005. IF: 1.937. PMID: 26722055
  • [20]
    FRIEDECKÝ, D., K. MIČOVÁ, E. FABER, M. HRDA, J. ŠIROKÁ a T. ADAM. Detailed study of imatinib metabolization using high-resolution mass spectrometry. Journal of Chromatography. 2015, 1409(-), 173-181. ISSN 0021-9673. IF: 3.926. PMID: 26199102
  • [19]
    ZEZULOVÁ, M., M. BARTOUŠKOVÁ, E. HLIDKOVA, T. ADAM, L. KUJOVSKA KRCMOVA, B. CERVINKOVA, D. SOLICHOVA, M. ZLEVOROVA, K. CWIERTKA, D. FRIEDECKÝ, D. VRÁNA a B. MELICHAR. Citrulline as a biomarker of gastrointestinal toxicity in patients with rectal carcinoma treated with chemoradiation. Clinical Chemistry and Laboratory Medicine . 2015, 54(2), 305-314. ISSN 1434-6621 . IF: 3.017. PMID: 26167980
  • [18]
    NAJDEKR, L., A. GARDLO, L. MÁDROVÁ, D. FRIEDECKÝ, H. JANEČKOVÁ, E. CORREA, R. GOODACRE a T. ADAM. Oxidized phosphatidylcholines suggest oxidative stress in patients with medium-chain acyl-CoA dehydrogenase deficiency. Talanta. 2015, 139(2015), 62-66. ISSN 0039-9140. IF: 4.035. PMID: 25882409
  • [17]
    LIGASOVÁ, A., D. STRUNIN, D. FRIEDECKÝ, T. ADAM a K. KOBERNA. A fatal combination: a thymidylate synthase inhibitor with DNA damaging activity. PLOS One. 2015, 10(2), 1-21. ISSN 1932-6203. IF: 3.057. PMID: 25671308
  • [16]
    JANEČKOVÁ, H., A. KALIVODOVÁ, L. NAJDEKR, D. FRIEDECKÝ, K. HRON, P. BRUHEIM a T. ADAM. Untargeted metabolomic analysis of urine samples in the diagnosis of some inherited metabolic disorders. Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czech Republic. 2015, 159(4), 582-585. ISSN 1213-8118. IF: 0.924. PMID: 25482736
  • [15]
    KANAGARATHAM, C., A. KALIVODOVÁ, L. NAJDEKR, D. FRIEDECKÝ, T. ADAM, M. HAJDÚCH, J.B. DE SANCTIS a D. RADZIOCH. Fenretinide prevents inflammation and airway hyperresponsiveness in a mouse model of allergic asthma. American Journal of Respiratory Cell and Molecular Biology. 2014, 51(6), 783-92. ISSN 1535-4989. IF: 3.985. PMID: 24885263
  • [14]
    BACOVSKY, J., M. MYSLIVECEK, J. MINARIK, V. SCUDLA, T. PIKA, J. ZAPLETALOVÁ, P. PETROVA, M. BARTKOVA, T. ADAM a S. GRONOWITZ. Analysis of thymidine kinase serum levels by novel method DiviTum™ in multiple myeloma and monoclonal gammopathy of undetermined significance - comparison with imaging methods 99mTc-MIBI scintigraphy and 18F-FDG PET/CT. Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czech Republic. 2014, 159(1), 100-103. ISSN 1213-8118. IF: 1.200. PMID: 24572488
  • [13]
    MIČOVÁ, K., D. FRIEDECKÝ, E. FABER a T. ADAM. Isotope dilution direct injection mass spectrometry method for determination of four tyrosine kinase inhibitors in human plasma. Talanta. 2012, 93(-), 307-317. ISSN 0039-9140. IF: 3.498. PMID: 22483915
  • [12]
    FABER, E., D. FRIEDECKÝ, K. MIČOVÁ, S. ROZMANOVA, M. DIVOKÁ, M. JAROSOVA, K. INDRAK a T. ADAM. Imatinib trough plasma levels do not correlate with the response to therapy in patients with chronic myeloid leukemia in routine clinical setting. Annals of Hematology. 2012, 91(6), 923-929. ISSN 0939-5555. IF: 2.866. PMID: 22231281
  • [11]
    JANEČKOVÁ, H., K. HRON, P. WOJTOWICZ, E. HLIDKOVA, A. BARESOVA, D. FRIEDECKÝ, L. ŽÍDKOVÁ, P. HORNIK, D. BEHULOVA, D. PROCHAZKOVA, H. VINOHRADSKA, K. PESKOVA, P. BRUHEIM, V. SMOLKA, S. STASTNA a T. ADAM. Targeted metabolomic analysis of plasma samples for the diagnosis of inherited metabolic disorders. Journal of Chromatography A. 2012, 1226(-), 11-17. ISSN 1873-3778. IF: 4.612. PMID: 22018716
  • [10]
    KVITVANG, H.F.N., T. ANDREASSEN, T. ADAM, S.G. VILLAS-BOAS a P. BRUHEIM. Highly Sensitive GC/MS/MS Method for Quantitation of Amino and Nonamino Organic Acids. Analytical Chemistry. 2011, 83(7), 2705-2711. ISSN 0003-2700. IF: 5.856. PMID: 21388201
  • [9]
    WOJTOWICZ, P., J. ZROSTLÍKOVÁ, T. KOVALCZUK, J. SCHUREK a T. ADAM. Evaluation of comprehensive two-dimensional gas chromatography coupled to time-of-flight mass spectrometry for the diagnosis of inherited metabolic disorders using an automated data processing strategy. Journal of Chromatography A. 2010, 1217(51), 8054-8061. ISSN 0021-9673. IF: 4.194. PMID: 20961553
  • [8]
    ŽÍDKOVÁ, L., J. KRIJT, J. SLADKOVA, A. HLOBILKOVA, M. MAGNER, M. ZIKANOVA, S. KMOCH, D. FRIEDECKÝ, J. ZEMAN, M. ELLEDER a T. ADAM. Oligodendroglia from ADSL-deficient patient produce SAICAribotide and SAMP. Molecular Genetics and Metabolism. 2010, 101(2-3), 286-288. ISSN 1096-7192. IF: 3.539. PMID: 20674424
  • [7]
    ŠRÁMEK, V., B. MELICHAR, J. INDRAKOVA, H. ŠTUDENTOVÁ, H. KALÁBOVÁ, D. VRÁNA, L. LUKESOVA, T. ADAM, E. HLIDKOVA, J. JURANOVA, P. PETROVA, L.K. KRCMOVA a D. SOLICHOVA. Risk factors of atherosclerosis in patients with history of breast cancer. Pteridines. 2013, 24(3-4), 201-210. ISSN 0933-4807. IF: 0.963.
  • [6]
    ŠRÁMEK, V., B. MELICHAR, H. ŠTUDENTOVÁ, H. KALÁBOVÁ, D. VRÁNA, L. LUKESOVA, T. ADAM, E. HLIDKOVA, J. JURANOVA a L. KRMOVA. Systemic immune response and peripheral blood cell count in patients with a history of breast cancer. Pteridines. 2013, 24(3-4), 211-217. ISSN 0933-4807. IF: 0.963.
  • [5]
    WOJTOWICZ, P., H. JANEČKOVÁ, D. FRIEDECKÝ a T. ADAM. Techniky metabolomiky v biomedicíně. Chemické Listy. 2013, 107(1), 3-11. ISSN 0009-2770. IF: 0.196.
  • [4]
    BARESOVA, A., D. FRIEDECKÝ a T. ADAM. Analysis of Nucleotides in Dry Blood Spots. Chemicke Listy. 2011, 105(3), 207-211. ISSN 0009-2770. IF: 0.529.
  • [3]
    KALIVODOVÁ, A., K. HRON, P. FILZMOSER, L. NAJDEKR, H. JANEČKOVÁ a T. ADAM. PLS-DA for Compositional Data with Application to Metabolomics. Journal of Chemometrics. 2015, 29(1), 21-28. ISSN 0886-9383. IF: 1.873.
  • [2]
    ŠTUDENTOVÁ, H., D. VITÁSKOVÁ, V. ŠRÁMEK, J. INDRAKOVA, T. ADAM, J. JURANOVA, P. PETROVA, L. KUJOVSKA KRCMOVA, E. PESKOVA, D. SOLICHOVA, H. KALÁBOVÁ a B. MELICHAR. Correlations of neutrophil-to-lymphocyte, lymphocyte-to-monote and platelet-to-lymphocyte ratios with biomarkers of atherosclerosis risk and inflammatory response in ptients with a history of breast cancer. Pteridines. 2015, 26, 161-172. ISSN 0933-4807. IF: 0.452.
  • [1]
    GARDLO, A., A. SMILDE, K. HRON, M. HRDA, R. KARLÍKOVÁ, D. FRIEDECKÝ a T. ADAM. Normalization techniques for PARAFAC modeling of urine metabolomic data. Metabolomics. 2016, 12(7), a.n. 117. ISSN 1573-3882. IF: 3.692.
  • Publications (Other Reviewed Journals)

  • [4]
    VROBEL, I., D. FRIEDECKÝ a T. ADAM. Analytický systém online extrakce na pevné fázi ve spojení s tandemovou spektrometrií a jeho klinické využití. Klinická biochemie a metabolismus. 2018, 26(47), 11-17. ISSN 2570-9402.
  • [3]
    JANEČKOVÁ, H., P. WOJTOWICZ, K. HRON, D. FRIEDECKÝ a T. ADAM. Necílená metabolomická analýza suchých krevních skvrn pro diagnostiku dědičných metabolických poruch. Klinická biochemie a metabolismus. 2012, 20(41), 167-169. ISSN 1210-7921.
  • [2]
    MIČOVÁ, K., D. FRIEDECKÝ, E. FABER a T. ADAM. Rutinní terapeutické monitorování tyrosinkinázových inhibitorů metodou LC-MS/MS. Klinická biochemie a metabolismus. 2012, 20(41), 222-225. ISSN 1210-7921.
  • [1]
    WOJTOWICZ, P., E. DOSTÁLOVÁ a T. ADAM. Analýza biologického materiálu dvojrozměrnou plynovou chromatografií. Klinická biochemie a metabolismus. 2012, 20(1), 38-40. ISSN 1210-7921.

  • Doctoral students mentor:

    [4] Lucie Mádrová, Study of the effect of selected cancerostatics on the cell metabolome,
    Ph.D. specialization: , status: Ongoing, from: 2015
    [3] Jan Václavík, Metabolomic tools for diagnosis of inherited metabolic disorders,
    Ph.D. specialization: , status: Ongoing, from: 2013
    [2] Jaroslava Jáčová, Metabolomic GC×GC-TOF MS analysis of biofluids,
    Ph.D. specialization: , status: Ongoing, from: 2013
    [1] Lukáš Najdekr, Metabolomic tools in diagnosis of inborn errors of metabolism,
    Ph.D. specialization: , status: Graduated, from: 2011 to 2017