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Džubák Petr M.D., Ph.D.
E-mail:
petr.dzubak@upol.cz
Phone:
+420 585632150, +420 604851158
Groups:
IMTM, LEM, STAFF, SUPERVISOR
About me
Scientist and pediatrician involved in molecular and translational medicine (disease area oncology and infectious diseases), leader of research program Chemical Biology and Experimental Therapeutics at IMTM. Actively participated in the research of more than 20 national and international projects; member of advisory board of Cancer Research Foundation „Rakovina ve veřejná“, co-founder of spin-off company focused on manufacturing of molecular diagnostics. Published more than >140 papers and books/chapters, >3552 SCI citations, H-index 27, Prix de Pharmacie 2007 Ambassade de France – Sanofi-aventis, Premier Prix.
Specialties: Molecular and translational medicine, Oncology, Drug research and development, MOA, Drug resistance
Journals
Lupane derivatives containing various aryl substituents in the position 3 have selective cytostatic effect in leukemic cancer cells including resistant phenotypes.
European Journal of Medicinal Chemistry.
2022,
244,
114850,
ISSN: 0223-5234,
PMID: 36283179,
Synthesis of Polycyclic Hetero-Fused 7-Deazapurine Heterocycles and Nucleosides through C-H Dibenzothiophenation and Negishi Coupling.
Journal of the American Chemical Society.
2022,
144(42),
19437-19446,
ISSN: 0002-7863,
PMID: 36245092,
Intellectual property
BENZOTHIAZOLE-SUBSTITUTED CYCLOBUT-3-ENE-1, 2-DIONE-3-HYDRAZONES AND THEIR USE IN THE TREATMENT OF VARIOUS TYPES OF LEUKEMIA AND TUMOUR DISEASES (Kaplánek)
- Patent: CZ 305538. Granted: 14.10.2015. Ownership: Institute of Chemical Technology Prague; Palacký University Olomouc; Institute of Molecular Genetics CAS. Inventors: KAPLÁNEK Robert, BŘÍZA Tomáš, HAVLÍK Martin, RAK Jakub, KEJÍK Zdeněk, DŽUBÁK Petr, HAJDÚCH Marián, KONEČNÝ Petr, ŠTĚPÁNKOVÁ Jana, KRÁLOVÁ Jarmila, KRÁL Vladimír
Status: Terminated
CHOLYL HYDRAZONES AND THEIR USE IN THE TREATMENT OF TUMOR AND LEUKEMIA DISEASES (Rak)
- Patent: CZ 305607. Granted: 25.11.2015. Ownership: Institute of Chemical Technology Prague, Palacký University Olomouc, Institute of Molecular Genetics CAS. Inventors: RAK Jakub, KAPLÁNEK Robert, ŠTULCOVÁ Tereza, DRAŠAR Pavel, HAVLÍK Martin, BŘÍZA Tomáš, DŽUBÁK Petr, HAJDÚCH Marián, KONEČNÝ Petr, ŠTĚPÁNKOVÁ Jana, KRÁLOVÁ Jarmila, KRÁL Vladimír
Status: Terminated
METHOD OF PREDICTING THE TUMOR RESPONSE TO DNA METHYLATION INHIBITORS AND ALTERNATIVE THERAPEUTIC REGIMENS FOR OVERCOMING RESISTANCE (Khushboo)
- Patent: EP 2924125 (ASH1L). Granted: 17.6.2017. Ownership: Palacký University Olomouc. Inventors: AGRAWAL Khushboo, FRYDRYCH Ivo, DŽUBÁK Petr, HAJDÚCH Marián
- Patent: EP 3042650 (JQ1). Granted: 10.6.2020. Ownership: Palacký University Olomouc. Inventors: AGRAWAL Khushboo, FRYDRYCH Ivo, DŽUBÁK Petr, HAJDÚCH Marián
- Published Application PCT/CZ2015/000029 under WO 2015/144102 (1.10.2015)
- Patent: EP 3122902 (BRD4). Granted: 16.5.2018. Ownership: Palacký University Olomouc. Inventors: AGRAWAL Khushboo, FRYDRYCH Ivo, DŽUBÁK Petr, HAJDÚCH Marián
- Published Application US 15/128,390 under US 20180251847 (6.9.2018)
- Patent: JP 6463372 (BRD4). Granted: 11.1.2019. Ownership: Palacký University Olomouc. Inventors: AGRAWAL Khushboo, FRYDRYCH Ivo, DŽUBÁK Petr, HAJDÚCH Marián
Status: Available
Open positions
| Project: | Identification of molecular targets and mechanisms of drug resistance by cellular methods biology and proteomics |
|---|---|
| Supervisors: | Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D. |
| Available: | 2 |
| Intended for: | Doctoral training |
| Summary: | 2 places in full-time study |
| Project: | Utilization of the space of unprecedented covalent inhibitors |
|---|---|
| Supervisors: | Dömling Alexander PhD., Džubák Petr M.D., Ph.D. |
| Available: | 1 |
| Intended for: | Doctoral training |
| Summary: | 1 place in full-time study |
| Project: | Identification of molecular targets of antitumor drugs using methods of cell biology and proteomics |
|---|---|
| Supervisors: | Džubák Petr M.D., Ph.D. |
| Available: | 2 |
| Intended for: | Doctoral training |
| Summary: | 2 places in full-time study |
| Project: | Identification of proteomic biomarkers in tears of patients with neurodegenerative diseases |
|---|---|
| Supervisors: | Džubák Petr M.D., Ph.D. |
| Available: | 1 |
| Intended for: | Doctoral training |
| Summary: | 1 place in full-time study |
| Project: | Genetic and epigenetic biomarkers of cancer diseases |
|---|---|
| Supervisors: | Slavkovský Rastislav Ph.D., Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D., Drábek Jiří Ph.D. |
| Available: | 3 |
| Intended for: | Doctoral training |
| Summary: | 3 places in full-time or combined form of study |
| Project: | Identification of proteomic biomarkers in exhaled air condensate in patients with systemic or pulmonary disease |
|---|---|
| Supervisors: | Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D. |
| Available: | 2 |
| Intended for: | Doctoral training |
| Summary: | 2 places in full-time study |
| Project: | Identification of proteomic biomarkers in tears of patients with brain cancer |
|---|---|
| Supervisors: | Džubák Petr M.D., Ph.D. |
| Available: | 1 |
| Intended for: | Doctoral training |
| Summary: | 1 place in full-time study |
| Project: | Antitumor drugs targeting nucleic acid metabolism |
|---|---|
| Supervisors: | Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D. |
| Available: | 2 |
| Intended for: | Doctoral training |
| Summary: | 2 places in full-time study |
| Project: | Targeted approaches to covalent inhibitors |
|---|---|
| Supervisors: | Dömling Alexander PhD., Džubák Petr M.D., Ph.D. |
| Available: | 1 |
| Intended for: | Doctoral training |
| Summary: | 1 place in full-time study |
| Project: | Synthesis of kinase inhibitors and their phenotypic chemoproteomic evaluation |
|---|---|
| Supervisors: | Dömling Alexander PhD., Džubák Petr M.D., Ph.D. |
| Available: | 1 |
| Intended for: | Doctoral training |
| Summary: | 1 place in full-time study |
| Project: | Identification of proteomic biomarkers in exhaled breath condensate patients with systemic or pulmonary disease |
|---|---|
| Supervisors: | Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D. |
| Available: | 2 |
| Intended for: | Doctoral training |
| Project: | Anticancer drugs targeting nucleic acid metabolism |
|---|---|
| Supervisors: | Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D. |
| Available: | 2 |
| Intended for: | Doctoral training |
| Project: | Genetic and epigenetic biomarkers in health and disease |
|---|---|
| Supervisors: | Slavkovský Rastislav Ph.D., Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D., Drábek Jiří Ph.D., Koudeláková Vladimíra Ph.D. |
| Available: | 5 |
| Intended for: | Doctoral training |
| Project: | Research and development of agents for cancer, neurodegenerative and infectious diseases |
|---|---|
| Supervisors: | De Sanctis Juan Bautista Ph.D., Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D., Urban Milan Ph.D., Das Viswanath M.Sc., Ph.D. |
| Available: | 5 |
| Intended for: | Doctoral training |
| Project: | Identification of proteomic biomarkers in proximal fluids and tissues |
|---|---|
| Supervisors: | Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D. |
| Available: | 2 |
| Intended for: | Doctoral training |
| Project: | Omic approaches in reproductive medicine |
|---|---|
| Supervisors: | Džubák Petr M.D., Ph.D., Oždian Tomáš Ph.D. |
| Available: | 1 |
| Intended for: | Doctoral training |
| Summary: | 1 place in full-time study |