Urban Milan Ph.D.

Journals

BORKOVÁ, L., I. FRYDRYCH, B. VRÁNOVÁ, N. JAKUBCOVÁ, B. LIŠKOVÁ, P. DŽUBÁK, P. PAVLIŠ, M. HAJDÚCH, M. URBAN
Lupane derivatives containing various aryl substituents in the position 3 have selective cytostatic effect in leukemic cancer cells including resistant phenotypes. European Journal of Medicinal Chemistry. 2022, 244, 114850, ISSN: 0223-5234, PMID: 36283179,
HODOŇ, J., I. FRYDRYCH, Z. TRHLÍKOVÁ, J. POKORNÝ, L. BORKOVÁ, S. BENICKÁ, M. VLK, B. LIŠKOVÁ, A. KUBÍČKOVÁ, M. MEDVEDÍKOVÁ, M. PISÁR, J. ŠAREK, V. DAS, A. LIGASOVÁ, K. KOBERNA, P. DŽUBÁK, M. HAJDÚCH, M. URBAN
Triterpenoid pyrazines and pyridines - Synthesis, cytotoxicity, mechanism of action, preparation of prodrugs. European Journal of Medicinal Chemistry. 2022, 243, 114777, ISSN: 0223-5234, PMID: 36174412,  PDF.
POKORNÝ, J., D. OLEJNÍKOVÁ, I. FRYDRYCH, B. LIŠKOVÁ, S. GURSKÁ, S. BENICKÁ, J. ŠAREK, J. KOTULOVÁ, M. HAJDÚCH, P. DŽUBÁK, M. URBAN
Substituted dienes prepared from betulinic acid - Synthesis, cytotoxicity, mechanism of action, and pharmacological parameters. European Journal of Medicinal Chemistry. 2021, 224, 113706, ISSN: 0223-5234, PMID: 34311159,

Doctoral mentorship

Šťastná Barbora

Modification of pentacyclic triterpene molecules in the E and A ring regions and study of their antitumor activity

Status: Ongoing from 2025.

Master mentorship

Orság Šimon

Preparation of new heterocyclic derivatives of triterpene

Status: Graduated from 2020 to 2022.
Jurčeka Ondřej

Triterpenes modified at the position 30

Status: Graduated from 2020 to 2022.
Borková Lucie Ph.D.

Modification of the position 2 in betulin, allobetulin and betulinic acid with polar substituents

Status: Graduated from 2012 to 2014.

Bachelor mentorship

Trhlíková Zdeňka

Preparation of heterocyclic triterpenes

Status: Graduated from 2013 to 2017.
Jurčeka Ondřej

Triterpenes modified at the position 30

Status: Graduated from 2018 to 2020.
Hodoň Jiří, Ph.D.

Attempt to find the mechanism of action in cytotoxic active triterpenes

Status: Graduated from 2012 to 2015.

Open positions

Project: Natural compounds with anti tumor activity
Supervisors: Urban Milan Ph.D.
Available: 2
Intended for: Doctoral training
Summary: 2 full-time positions
Project: Research and development of agents for cancer, neurodegenerative and infectious diseases
Supervisors: De Sanctis Juan Bautista Ph.D., Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D., Urban Milan Ph.D., Das Viswanath M.Sc., Ph.D.
Available: 5
Intended for: Doctoral training