Skip to main content

About us

The IMTM Molecular diagnostics core facility offer top services in tumor genetics and human virology. The Diagnostic Core Facility is focused mainly on the detection of predictive tumor biomarkers and detection of tumor-assocciated viruses, e.g. human papillomavirus. The facility is fully equipped with state-of-the-art technologies and staffed by a team of highly skilled and specialized experts.

Why choose us:

  • State-of-the-Art Technology: Our facility is equipped with the latest technologies and instruments for high-quality results.
  • Expert Team: Our team of specialized geneticists and laboratory technicians with many years of experience is here to provide personalized assistance.
  • Quality assurance: All diagnostic methods are accredited according to the ISO 15189 standard. International external quality controls are carried out several times a year.
  • Personalized approach: We fully understand the importance of laboratory examination for the individual client therefore we offer an individual and fully personalized approach.
Panel sequencing in solid tumors

Molecular analysis of solid tumors allows for personalized treatment approaches based on the specific genetic alterations present in an individual's tumor. This can help match patients with targeted therapies that are more likely to be effective, improving treatment outcomes and reducing unnecessary side effects. Molecular analysis of solid tumors can identify specific genetic alterations and molecular pathways that drive tumor growth and progression and could be targetable by tailored therapy. Next-genome sequencing (NGS) allows for the simultaneous analysis of multiple genes or genomic regions as well as tumor mutation burden and microsatellite instability, providing comprehensive genetic profiling of solid tumors.

Human papillomavirus testing

Human papillomavirus (HPV) is a common sexually transmitted infection that can cause various types of warts and has been associated with certain types of cancer, such as cervical, oropharyngeal, anal, vaginal, and penile cancer. HPV testing is performed by real-time PCR with full genotyping. Real-time PCR is able to detect and identified all clinically important low-risk and high-risk HPVs.

Whole exome sequencing (WES)

Whole exome sequencing technology is to analyze entire human (or other organisms) exomes comprehensively and accurately. Genomic DNA is first randomly fragmented using sonication or nebulization, and then are ligated to a platform-specific set of double-stranded adapters to generate a shotgun library. Subsequently, these library fragments are amplified in situ by hybridization and extension from complementary adapters. NGS is preformed using the NovaSeq 6000 platform, a microfluidic device to contain the amplified fragments of the shotgun library, followed by an imaging step that collects data from fragments being actively sequenced. WES is more economical and higher throughput approach to WGS enabling deeper sequencing and detection of mosaics or somatic mutations.

Vitamin D3 analysis by LC-MS

Vitamin D3 analysis by LC-MS quantifies the metabolite 25OH-VitD3, distinguishing between epi-25OH-D3 and 25OH-D3. This method precisely measures these forms of vitamin D metabolites, important for assessing overall vitamin D status and its various health impacts.

Roche Light Cycler 480 II Real-time PCR cycler
Reserve this instrument
Corbett Research Rotor-Gene RG-3000 Real-time PCR cycler
Reserve this instrument
Bio-Rad CFX 96 real-time PCR cycler
Reserve this instrument
Unlimited number of files can be uploaded to this field.
256 MB limit.
Allowed types: gif, jpg, jpeg, png, bmp, eps, tif, pict, psd, txt, rtf, html, odf, pdf, doc, docx, ppt, pptx, xls, xlsx, xml, avi, mov, mp3, mp4, ogg, wav, bz2, dmg, gz, jar, rar, sit, svg, tar, zip.
I understand, that by submitting the project proposal submission form above, I accept that EATRIS-CZ, represented by the national node, The Institute of Molecular and Translational Medicine (IMTM), Faculty of Medicine and Dentistry, Palacký University in Olomouc, will process my personal data only for the purpose of replying to the project proposal and related information provided in the form.
I understand the information and data provided above are of non-confidential nature and can be processed by EATRIS-CZ for the purposes of internal project evaluation and partnering
CAPTCHA
Enter the characters shown in the image.
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

If you have any questions , please don't hesitate to reach out to us. Our friendly and knowledgeable team is ready to assist you. You can contact us through the following methods:

 

  • Phone: +420 585 632 089
  • Email: diagnostics.imtm@upol.cz 
  • Location: Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry and Czech Advanced Technology and Research Institute, Palacky University, Hnevotinska 5, 779 00 Olomouc, Czech Republic
Jaworek Hana Ph.D.
IMTM, LEM, STAFF
Drábek Jiří Ph.D.
FACULTY OF SCIENCE, IMTM, LEM, STAFF, SUPERVISOR
Slavkovský Rastislav Ph.D.
IMTM, LEM, POSTDOCTORAL FELLOW, STAFF
Stránská Jana Ph.D.
IMTM, LEM, POSTDOCTORAL FELLOW, STAFF
Bouška Ondřej
DOCTORAL STUDENT, IMTM, LEM, STAFF
Najdekr Lukáš Ph.D.
IMTM, LEM, METABOLOMICS, STAFF, SUPERVISOR
Kubáňová Kateřina Mgr.
BACHELOR STUDENT, DOCTORAL STUDENT, IMTM, LEM, MASTER STUDENT, STAFF
Továrková Lucie
IMTM, LEM, STAFF