Urban Milan Ph.D.

Akademický titul: Professor

Telefon: +420 585 632 197

Skupiny: PŘÍRODOVĚDECKÁ FAKULTA, IMTM, MEDCHEM, PERSONÁL, VEDOUCÍ

I am a scientist in the field of medicinal chemistry with current focus on natural products with various biological activities. Since 2012 I am a leader of an independent research group that currently has 2 postdocs, 4 PhD and 8 undergraduate students. Our research consists of organic synthesis, evaluation of activities and mechanism of action. I have been a PI of several grant projects from Czech Science Agency and from the Ministry of Health of the Czech Republic. Currently I serve on an evaluation panel of Czech Science Agency (P207). Earlier in my career, I was also involved in nucleic acid research, enzymology and biochemistry in general. In addition, I teach classes on bioorganic chemistry, chemical biology, and chemistry of nucleic acids. Published more than 40 papers, 3 book chapters, 4 patents, >1500 SCI citations, H-index 21.

ORCID: http://orcid.org/0000-0002-8249-028X

Researcher ID: C-9611-2010

KAZAKOVA, A., I. FRYDRYCH, N. JAKUBCOVÁ, J. POKORNÝ, B. LIŠKOVÁ, S. GURSKÁ, P. DŽUBÁK, M. HAJDÚCH, M. URBAN

Novel triterpenoid pyrones, phthalimides and phthalates are selectively cytotoxic in CCRF-CEM cancer cells - Synthesis, potency, and mitochondrial mechanism of action. European Journal of Medicinal Chemistry. 2024, 269, 116336, ISSN: 0223-5234, PMID: 38520761, PDF.

BORKOVÁ, L., I. FRYDRYCH, B. VRÁNOVÁ, N. JAKUBCOVÁ, B. LIŠKOVÁ, P. DŽUBÁK, P. PAVLIŠ, M. HAJDÚCH, M. URBAN

Lupane derivatives containing various aryl substituents in the position 3 have selective cytostatic effect in leukemic cancer cells including resistant phenotypes. European Journal of Medicinal Chemistry. 2022, 244, 114850, ISSN: 0223-5234, PMID: 36283179,

HODOŇ, J., I. FRYDRYCH, Z. TRHLÍKOVÁ, J. POKORNÝ, L. BORKOVÁ, S. BENICKÁ, M. VLK, B. LIŠKOVÁ, A. KUBÍČKOVÁ, M. MEDVEDÍKOVÁ, M. PISÁR, J. ŠAREK, V. DAS, A. LIGASOVÁ, K. KOBERNA, P. DŽUBÁK, M. HAJDÚCH, M. URBAN

Triterpenoid pyrazines and pyridines - Synthesis, cytotoxicity, mechanism of action, preparation of prodrugs. European Journal of Medicinal Chemistry. 2022, 243, 114777, ISSN: 0223-5234, PMID: 36174412, PDF.

Borková Lucie Ph.D.

Modification of the position 2 in betulin, allobetulin and betulinic acid with polar substituents

Stav: Absolvoval od 2012 do 2014.

1 Molecular and Translational Medicine

Projekt:	Research and development of agents for cancer, neurodegenerative and infectious diseases
Vedoucí:	De Sanctis Juan Bautista Ph.D., Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D., Urban Milan Ph.D., Das Viswanath M.Sc., Ph.D.
K dispozici:	5
Určeno pro:	Doctoral training

1 Molekulární a translační medicína

Projekt:	Natural compounds with anti tumor activity
Vedoucí:	Urban Milan Ph.D.
K dispozici:	2
Určeno pro:	Doktorské studium
Souhrn:	2 místa na plný úvazek

Urban Milan Ph.D.

O mně

Journals

Doctoral mentorship

Šťastná Barbora

Master mentorship

Orság Šimon

Jurčeka Ondřej

Borková Lucie Ph.D.

Bachelor mentorship

Trhlíková Zdeňka

Jurčeka Ondřej

Hodoň Jiří, Ph.D.

Volná místa