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Koberna Karel CSc.

Journals

A new technique for the analysis of metabolic pathways of cytidine analogues and cytidine deaminase activities in cells. Scientific Reports. 2023, 13(1), 20530, ISSN: 2045-2322 , PMID: 37993628,
Basic Methods of Cell Cycle Analysis. International Journal of Molecular Sciences. 2023, 24(12), 3674, ISSN: 1422-0067, PMID: 36835083, DATA.
HODOŇ, J., I. FRYDRYCH, Z. TRHLÍKOVÁ, J. POKORNÝ, L. BORKOVÁ, S. BENICKÁ, M. VLK, B. LIŠKOVÁ, A. KUBÍČKOVÁ, M. MEDVEDÍKOVÁ, M. PISÁR, J. ŠAREK, V. DAS, A. LIGASOVÁ, K. KOBERNA, P. DŽUBÁK, M. HAJDÚCH, M. URBAN
Triterpenoid pyrazines and pyridines - Synthesis, cytotoxicity, mechanism of action, preparation of prodrugs. European Journal of Medicinal Chemistry. 2022, 243, 114777, ISSN: 0223-5234, PMID: 36174412, DATA.

Books & book chapters

In situ detection of overall and replicated mitochondrial DNA in mammalian cells , 1.vyd., Olomouc, Palacky University, 2021, 18, 129-140, Dedication: LO1304, ISBN: 978-80-244-6049-9,
In situ detection of replicated DNA in mammalian cell nuclei , 1.vyd., Olomouc, Palacky University, 2021, 17, 119-128, Dedication: LO1304, ISBN: 978-80-244-6049-9,
Laboratory Techniques in Cellular and Molecular Medicine, 1.vyd., Olomouc, Palacky University, 2021, 436 s, Dedication: LO1304, ISBN: 978-80-244-6049-9,

Intellectual property

A METHOD OF INCREASING THE SIGNAL OF ANTIBODIES RECOGNIZING 5-BROMO-2'-DEOXYURIDINE AND/OR 5-CHLORO-2'-DEOXYURIDINE AND/OR 5-IODO-2'-DEOXYURIDINE AT SITES OF INCORPORATION OF THESE NUCLEOSIDES INTO DNA FOR DNASE I ACTIVITY (Koberna)

Patent: CZ 307807; Granted: 10.4.2019; Ownership: Palacky University, Olomouc; Inventors: Koberna KarelLigasová Anna

Status: Terminated

METHOD FOR SELECTIVE REMOVAL OF DNA DYES, KIT FOR SELECTIVE REMOVAL OF DNA DYES AND THEIR USE (Koberna)

1. Patent: CZ 308385; Granted: 4.6.2020; Ownership: Palacky University, Olomouc; Inventors: Koberna Karel, Ligasová Anna

Status: Terminated

KIT FOR MAKING SPECIFIC PYRIMIDINE NUCLEOTIDES IN THE STRUCTURE OF DOUBLE-STANDED DNA TO REACT WITH ANTIBODIES THAT REACT WITH THESE NUCLEOSIDES (Koberna)
  1. Utility Model: CZ 28964, Granted: 14.12.2015, Ownership: Palacky University Olomouc, Inventors: Koberna KarelLigasová Anna

Status: Terminated

Master mentorship

Zálešáková Zuzana

Testing and optimization of new non-destructive method for determining the activity of cytidine deaminase for use of various cell lines

Status: Graduated from 2015 to 2017.

Bachelor mentorship

Moštěk Jan

Base excision repairs

Status: Graduated from 2017 to 2021.
Pasecká Martina

Optimization of the method for determining the activity of uracil glycosylase and its application to compare the activity of uracil glycosylase in different cell lines

Kociánová Markéta

Metabolic pathways of deoxycytidine and their impact on the cancer treatment by deoxycytidine analog

Status: Ongoing from 2023.

Open positions

Project: Metabolic pathways of deoxycytidine and their impact on the cancer treatment by deoxycytidine analog
Supervisors: Koberna Karel CSc.
Available: 1
Intended for: Bachelor training
Summary: Metabolic pathways of deoxycytidine and their impact on the cancer treatment by deoxycytidine analog