Effects of perioperative opioid analgesia on circulating tumor cells in colorectal cancer: multicenter randomized clinical trial

Project acronym: NV18-03-00470
Project title: Effects of perioperative opioid analgesia on circulating tumor cells in colorectal cancer: multicenter randomized clinical trial
Project registration number: NV18-03-00470
State funding provider: The Ministry of Health
Programme: NV - Programme for the Support of Applied Medical Research for the years 2015 - 2023 (2015 - 2023)
Start date: 2018-05-01
End date: 2022-12-31
Principal investigator: Hajdúch Marián M.D., Ph.D.

Perioperative analgesia techniques (PAT) with favorable effects on cancer recurrence (CR) would decrease morbidity/mortality. In colorectal cancer (CRC) surgery, we showed that CR correlates with circulating tumor cells (CTCs) presence in the early postoperative period and that morphine- but not piritramide-based PA increases CTCs presence and shortens disease-free survival. Also epidural PA may influence CR favorably. To identify PAT preventing CR and individualize PA, project objectives include: 1. Prospective, randomized, multicenter trial (PRMT) comparing effects of morphine- and piritramide-based PA on CTCs presence in laparoscopic CRC surgery, including analysis of opioid and cannabinoid receptor subtypes in cancer tissue. 2. PRMT comparing effects of epidural, morphine- and piritramide-based PA on CTCs presence in open CRC surgery. 3. Retrospective study on the influence of morphine- and piritramide-based PA on CTCs presence and survival in CRC surgery including analysis of opioid and cannabinoid receptor subtypes in cancer tissue.