Skip to main content

Innovative Chemistry

Laboratory of Medicinal and Organic Chemistry
Senior research group

The Innovative Chemistry group focuses on the development of a fast, efficient and semi-automated synthesis technology platform suitable for optimizing the properties of compounds in a (semi-)automated, miniaturized and accelerated manner using in-house developed generative artificial intelligence algorithms. A technology platform called AMADEUS will be applied to R&D issues in medicinal chemistry, development of nanomaterials as well as plant protection agents and biostimulants. The fundamental challenge of this research is expressed in the mantra 'automation + miniaturization = acceleration', which has been successfully applied in many technologies and research areas. Miniaturization together with automation will increase the throughput and flow of "big data" to reduce cost, energy, waste, and bring products to the market faster. Automation and miniaturization will thus contribute significantly to the Sustainable Development Goals set by the United Nations and the commitments of the Green Deal for Europe and will dramatically reduce the ecological footprint of future chemistry.

  • Multicomponent reaction chemistry (MCR), basics, mechanism, and stereocontrol
  • Discovery of novel multicomponent reactions
  • Isocyanide chemistry
  • Automation of synthetic chemistry
  • Miniaturization of synthetic chemistry
  • HT chemistry
  • HT screening, phenotypical, biophysical
  • Application of MCR in structure-based, fragment-based and rational drug discovery
  • Anticancer, anti-infective, anti-inflammatory drug discovery
PATIL, P., Q. ZHENG, K. KURPIEWSKA, A. DÖMLING
The isocyanide SN2 reaction. Nature Communications. 2023, 14(1), 5807, ISSN: 2041-1723, PMID: 37726293,
WAZYNSKA, M., R. BUTERA, M. REQUESENS, A. PLAT, T. ZARGANES-TZITZIKAS, C. NEOCHORITIS, J. PLEWKA, L. SKALNIAK, J. KOCIK-KROL, B. MUSIELAK, K. MAGIERA-MULARZ, I. RODRIGUEZ, S. BLOK, M. DE BRYUN, H. NIJMAN, P. ELSINGA, T. HOLAK, A. DÖMLING
Design, Synthesis, and Biological Evaluation of 2-Hydroxy-4-phenylthiophene-3-carbonitrile as PD-L1 Antagonist and Its Comparison to Available Small Molecular PD-L1 Inhibitors. Journal of Medicinal Chemistry. 2023, 66(14), 9577-9591, ISSN: 0022-2623, PMID: 37450644,