Loubalová Zuzana

Cytogenetic changes in colorectal cancer patients

Master’s thesis is focused on cytogenetic changes in colorectal cancer patients. The student will propose and construct series of DNA probes suitable for fluorescence in situ hybridizations (FISH). By using this set will be possible to describe degree of deletions on q-arm of chromosome 18. Deletions of 18q involve DCC gene and are often find in colorectal cancer patients. The impact of this mutation is still discussed and the data are not consitent. As was newly found, in this region other 3 genes responsible for chomosome instability are located. Therfore is possible that for clinical imact would be important the the degree of the deletion.