Škrott Zdeněk Ph.D.

Journals

HUANG, J., J. CAMPIAN, T. DEWEES, Z. ŠKROTT, M. MISTRÍK, T. JOHANNS, G. ANSSTAS, O. BUTT, E. LEUTHARDT, G. DUNN, G. ZIPFEL, J. OSBUN, C. ABRAHAM, S. BADIYAN, K. SCHWETYE, J. CAIRNCROSS, J. RUBIN, A. KIM, M. GHEDA
A phase 1/2 study of disulfiram and copper with concurrent radiation therapy and temozolomide for patients with newly diagnosed glioblastoma. International journal of radiation oncology, biology, physics. 2024, ISSN: 0360-3016, PMID: 38768767.
LÖFFELMANN, M., Z. ŠKROTT, D. MAJERA, P. STARHA, V. KRYŠTOF, M. MISTRÍK
Identification of novel dithiocarbamate-copper complexes targeting p97/NPL4 pathway in cancer cells. European Journal of Medicinal Chemistry. 2023, 261, 115790, ISSN: 0223-5234 , PMID: 37690264,
KANELLIS, D., A. ZISI, Z. ŠKROTT, B. LEMMENS, J. ESPINOZA, M. KOSAR, A. BJÖRKMAN, X. LI, S. ARAMPATZIS, J. BARTKOVA, M. ANDUJAR-SANCHEZ, O. FERNANDEZ-CAPETILLO, M. MISTRÍK, M. LINDSTROM, J. BÁRTEK
Actionable cancer vulnerability due to translational arrest, p53 aggregation and ribosome biogenesis stress evoked by the disulfiram metabolite CuET. Cell Death and Differentiation. 2023, ISSN: 1350-9047, PMID: 37142656,

Books & book chapters

ŠKROTT, Z.
Methods for detection and induction of proteotoxic stress response in mammalian cells , 1.vyd., Olomouc, Palacky University, 2021, 23, 169-176, Dedication: LO1304, ISBN: 978-80-244-6049-9,

Intellectual property

LIQUID CHROMATOGRAPHY COLUMN (Mistrík)

Utility Model: CZ 35118. Granted: 1.6.2021. Ownership: Palacký University Olomouc. Inventors: MISTRÍK Martin, ŠKROTT Zdeněk, OŽDIAN Tomáš.

Status: Available

MOLECULAR COMPLEX ASSEMBLY PARTICLES COMRISING BIS-R1, R2-DITHIOCARBAMATE-METAL COMPLEX AND A LIGAND, METHOD OF PREPARATION AND USE THEREOF "DISULFIRAM II" (Mistrík)
  1. Published Application EP 18199181.1 under EP 3636285 (15.4.2020)
  2. Published Application PCT/EP2019/077222 under WO 2020/074514 (16.4.2020)
  3. Patent: AU 2019358428. Granted: 17.11.2022. Ownership: Palacký University Olomouc. Inventors: MISTRÍK Martin, BÁRTEK Jiří, ŠKROTT Zdeněk, DŽUBÁK Petr, HAJDÚCH Marián
  4. Patent: CA 3,114,031. Granted: 12.3.2024. Ownership: Palacký University Olomouc. Inventors: MISTRÍK Martin, BÁRTEK Jiří, ŠKROTT Zdeněk, DŽUBÁK Petr, HAJDÚCH Marián
  5. Patent: IL 281616. Granted: 2.4.2024. Ownership: Palacký University Olomouc. Inventors: MISTRÍK Martin, BÁRTEK Jiří, ŠKROTT Zdeněk, DŽUBÁK Petr, HAJDÚCH Marián
  6. Patent: JP 7220932. Granted: 3.2.2023. Ownership: Palacký University Olomouc. Inventors: MISTRÍK Martin, BÁRTEK Jiří, ŠKROTT Zdeněk, DŽUBÁK Petr, HAJDÚCH Marián
  7. Patent: KR 10-2626651. Granted: 17.1.2024. Ownership: Palacký University Olomouc. Inventors: MISTRÍK Martin, BÁRTEK Jiří, ŠKROTT Zdeněk, DŽUBÁK Petr, HAJDÚCH Marián

Status: Patents pending, Available

DISULFIRAM I (Škrott)
  1. Patent: EP 3459526. Granted: 24.2.2021. Ownership: Palacký University Olomouc. Inventors: Škrott Zdeněk, Mistrík Martin, Hajdúch Marián, Bártek Jiří, Džubák Petr, Zbořil Radek.
  2. Published Application PCT/EP2018/076098 under WO 2019/063601 (4.4.2019)
  3. Patent: US 11,766,404. Granted: 26.9.2023. Ownership: Palacký University Olomouc. Inventors: Škrott Zdeněk, Mistrík Martin, Hajdúch Marián, Bártek Jiří, Džubák Petr, Zbořil Radek.
  4. Patent: AU 2018340510. Granted: 5.8.2021. Ownership: Palacký University Olomouc. Inventors: Škrott Zdeněk, Mistrík Martin, Hajdúch Marián, Bártek Jiří, Džubák Petr, Zbořil Radek.
  5. EP 18774061.9 - patent pending.
  6. Patent: IL 273652. Granted: 2.1.2024. Ownership: Palacký University Olomouc. Inventors: Škrott Zdeněk, Mistrík Martin, Hajdúch Marián, Bártek Jiří, Džubák Petr, Zbořil Radek.
  7. Patent: CA 3,076,855. Granted: 26.4.2022. Ownership: Palacký University Olomouc. Inventors: Škrott Zdeněk, Mistrík Martin, Hajdúch Marián, Bártek Jiří, Džubák Petr, Zbořil Radek.
  8. Patent: KR 10-2456683. Granted: 14.10.2022. Ownership: Palacký University Olomouc. Inventors: Škrott Zdeněk, Mistrík Martin, Hajdúch Marián, Bártek Jiří, Džubák Petr, Zbořil Radek.
  9. Patent: JP 7149624. Granted: 29.9.2022. Ownership: Palacký University Olomouc. Inventors: Škrott Zdeněk, Mistrík Martin, Hajdúch Marián, Bártek Jiří, Džubák Petr, Zbořil Radek.
  10. Patent: MX 396,552. Granted: 17.10.2022. Ownership: Palacký University Olomouc. Inventors: Škrott Zdeněk, Mistrík Martin, Hajdúch Marián, Bártek Jiří, Džubák Petr, Zbořil Radek.

Status: Available

Master mentorship

Machačová Zuzana M.Sc.

The role of the p97 / NPL4 protein complex in repairing damaged DNA

Status: Graduated from 2019 to 2021.
Löffelmann Martin

Identification of new inhibitors of NPL4 protein and insight into the mechanism of their action

Status: Graduated from 2020 to 2022.
Svobodová Natálie

Targeting heat shock proteins in cancer

Status: Ongoing from 2023.

Bachelor mentorship

Třeštík Jan

Targeting cell stress pathways in cancer

Status: Ongoing from 2024.
Soos Andrej

Crosstalk between the ubiquitin proteasome system and genome integrity

Status: Graduated from 2016 to 2017.
Kempná Magdalena

Targeting NPL4 protein in cancer

Status: Graduated from 2019 to 2020.

Open positions

Project: Cellular stress in health and disease
Supervisors: Mistrík Martin Ph.D., Moudrý Pavel Ph.D., Škrott Zdeněk Ph.D.
Available: 3
Intended for: Doctoral training