Virology and molecular carcinogenesis

Laboratory of Experimental Medicine
Junior research group

The research is focused on human virology, public health surveillance, the molecular mechanisms of virus-driven infections, diseases and specifically carcinogenesis. The group is focused mainly on HPV-associated diseases, SARS-CoV-2 immunity, and cancer genetics. The Laboratory of virology and molecular carcinogenesis was recently established as a junior research group. The researchers from the Laboratory of virology and molecular carcinogenesis are involved in molecular investigation of human papillomaviruses (HPV) and recently in SARS-CoV-2 infections. The workplace is fully equipped with state-of-the-art instruments for genetic and molecular biology analyses of human biological materials.

  • Human virology
  • Public health surveillance
  • Molecular carcinogenesis of HPV-driven cancers
  • SARS-CoV-2 immunity
  • National screening and vaccination programmes improvement
  • New approaches in screening testing
  • Diagnostic and therapeutic targets
  1. KOPRETINA trial – The main goal of the study is to determine the prevalence and genotype distribution of Human Papillomavirus in vaccinated/unvaccinated Czech women. The second goal is to evaluate the usage of self-sampling device mainly in women who do not participate in cytology-based cervical cancer screening and in women who participate in cervical cancer screening.
  2. Liquid biopsies - a possible tool for treatment monitoring and early recurrence detection in HPV-associated diseases – The main goal of the study is monitoring of HPV DNA dynamics in patients with HPV-positive oropharyngeal and cervical cancer/precancer. The second goal is to evaluate the importance of circulating HPV DNA in liquid biopsies for the treatment efficacy and relapse monitoring.
  3. PREVAL - Study of Collective Immunity – The main goal of the study is to evaluate the amount of SARS-CoV-2 antibodies, the presence of infection and the cell immunity response in people from Olomouc region.
JAWOREK, H., V. KOUDELÁKOVÁ, J. DRÁBEK, J. VRBKOVÁ, B. ZBORILOVA, I. OBORNA, J. BREZINOVA, R. MAREK, K. HUML, P. VANEK, M. HAJDÚCH
A Head-to-Head Analytical Comparison of Cobas 4800 HPV, PapilloCheck HPV: Screening, and LMNX Genotyping Kit HPV GP for Detection of Human Papillomavirus DNA in Cervical and Cervicovaginal Swabs. The Journal of Molecular Diagnostics. 2018, 20(6), 849-858, ISSN: 1525-1578, PMID: 30165205,  PDF.
KOUDELÁKOVÁ, V., J. BERKOVCOVÁ, R. TROJANEC, J. VRBKOVÁ, L. RADOVÁ, J. EHRMANN, Z. KOLÁŘ, B. MELICHAR, M. HAJDÚCH
Evaluation of HER2 Gene Status in Breast Cancer Samples with Indeterminate Fluorescence in Situ Hybridization by Quantitative Real-Time PCR Method. Journal of Molecular Diagnostic. 2015, 17(4), 446-455, ISSN: 1525-1578, PMID: 25956448,  PDF.
Project: Genetic and epigenetic biomarkers in health and disease
Supervisors: Slavkovský Rastislav Ph.D., Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D., Drábek Jiří Ph.D., Koudeláková Vladimíra Ph.D.
Available: 5
Intended for: Doctoral training

Group members

DOCTORAL STUDENT, EXSTAFF, IMTM, LEM
EXSTAFF, IMTM, LEM
BACHELOR STUDENT, DOCTORAL STUDENT, IMTM, LEM, MASTER STUDENT, STAFF
IMTM, LEM, POSTDOCTORAL FELLOW, STAFF
EXSTAFF, IMTM, LEM