Virology and molecular carcinogenesis

Laboratory of Experimental Medicine
Junior research group

The research is focused on human virology, public health surveillance, the molecular mechanisms of virus-driven infections, diseases and specifically carcinogenesis. The group is focused mainly on HPV-associated diseases, SARS-CoV-2 immunity, and cancer genetics. The Laboratory of virology and molecular carcinogenesis was recently established as a junior research group. The researchers from the Laboratory of virology and molecular carcinogenesis are involved in molecular investigation of human papillomaviruses (HPV) and recently in SARS-CoV-2 infections. The workplace is fully equipped with state-of-the-art instruments for genetic and molecular biology analyses of human biological materials.

  • Human virology
  • Public health surveillance
  • Molecular carcinogenesis of HPV-driven cancers
  • SARS-CoV-2 immunity
  • National screening and vaccination programmes improvement
  • New approaches in screening testing
  • Diagnostic and therapeutic targets
  1. KOPRETINA trial – The main goal of the study is to determine the prevalence and genotype distribution of Human Papillomavirus in vaccinated/unvaccinated Czech women. The second goal is to evaluate the usage of self-sampling device mainly in women who do not participate in cytology-based cervical cancer screening and in women who participate in cervical cancer screening.
  2. Liquid biopsies - a possible tool for treatment monitoring and early recurrence detection in HPV-associated diseases – The main goal of the study is monitoring of HPV DNA dynamics in patients with HPV-positive oropharyngeal and cervical cancer/precancer. The second goal is to evaluate the importance of circulating HPV DNA in liquid biopsies for the treatment efficacy and relapse monitoring.
  3. PREVAL - Study of Collective Immunity – The main goal of the study is to evaluate the amount of SARS-CoV-2 antibodies, the presence of infection and the cell immunity response in people from Olomouc region.
JAWOREK, H., V. KOUDELÁKOVÁ, I. OBORNA, B. ZBORILOVA, J. BREZINOVA, D. RUZICKOVA, J. VRBKOVÁ, P. KOUŘILOVÁ, M. HAJDÚCH
Impact of human papillomavirus infection on semen parameters and reproductive outcomes. Reproductive biology and endocrinology. 2021, 19(1), 156, ISSN: 1477-7827, PMID: 34627284,
KLEMPT, D., O. BRZON, M. KAŠNÝ, K. KVAPILOVA, P. HUBACEK, A. BRIKSI, M. BEZDICEK, V. KOUDELÁKOVÁ, M. LENGEROVA, M. HAJDÚCH, P. DREVINEK, S. POSPISILOVA, E. KRIEGOVA, E. KRIEGOVA, M. MACEK
Distribution of SARS-CoV-2 Lineages in the Czech Republic, Analysis of Data from the First Year of the Pandemic. Microorganisms. 2021, 9(8), 1671, ISSN: 2076-2607, PMID: 34442750,  PDF.
JAWOREK, H., B. ZBORILOVA, V. KOUDELÁKOVÁ, J. BREZINOVA, J. VRBKOVÁ, I. OBORNA, M. HAJDÚCH
Prevalence of Human Papillomavirus Infection in Oocyte Donors and Women Treated for Infertility: An Observational Laboratory-Based Study. European Journal of Obstetrics & Gynecology and Reproductive Biology: X. 2019, 4, 100068, ISSN: 2590-1613, PMID: 1517300,
Projekt: Genetic and epigenetic biomarkers in health and disease
Vedoucí: Slavkovský Rastislav Ph.D., Džubák Petr M.D., Ph.D., Hajdúch Marián M.D., Ph.D., Drábek Jiří Ph.D., Koudeláková Vladimíra Ph.D.
K dispozici: 5
Určeno pro: Doktorské studium

Group members

DOKTORSKÝ STUDENT, ÚMTM, LEM, PERSONÁL
EX ZAMĚSTNANCI, ÚMTM, LEM
BAKALÁŘSKÝ STUDENT, DOKTORSKÝ STUDENT, ÚMTM, LEM, MAGISTERSKÝ STUDENT, PERSONÁL
ÚMTM, LEM, POSTDOKTORSKÝ STUDENT, PERSONÁL
ÚMTM, LEM, PERSONÁL