IMTM board

I earned my M.Sc. in Biology and Ecology from Faculty of Sciences Palacky University Olomouc, Czech Republic. I worked as a Clinical Research Specialist for several pharmaceutical and contract research companies, including Icon Clinical Research, MerckSerono, AstraZeneca in Czech Republic and other European countries.  I joined IMTM, Olomouc in 2018 as a Clinical Research Manager. I am responsible for clinical trials from the start-up phase to the study completion activities, including the data management. 

Group leader of the Translational Disease Models and Neurodegeneration at the Institute of Molecular and Translational Medicine. We're a dynamic team with a two-fold focus, each facet contributing to the broader goal of unravelling the mysteries of neurodegenerative disorders and translating our findings into tangible therapies.

 Please follow the link to my research home page for more information on what we do: https://www.imtm.cz/laboratories/translational-disease-models-and-neurodegeneration

Prof. Jiří Drábek, PhD. is the head of the LEM DNA laboratory and the representative for education at the IMTM. He is a forensic genetics expert, external auditor for ISO/IEC 17025, president of the Czechoslovak Society for Forensic Genetics, z.s., and editor of the journal Forensic Science International: Genetics.

He received a Master's degree from Masaryk University in Brno, a PhD and habilitation from Palacký University in Olomouc, and a professorship at Charles University. He is professionally influenced by a PhD internship at Trinity College, Oxford, UK, a postdoctoral fellowship at Ohio University, Athens, USA, and a SEFE course organized by the University of Lausanne, Switzerland.

Dr. Drabek's professional interests include reproducible prognostic/predictive cancer biomarkers and laboratory techniques for genotyping and forensic DNA profiling. He enjoys critical thinking and Bayesian interpretation of results.

I am working in the high throughput screening facility with focus on the testing of new chemical compounds, the implementation and validation of new biochemical and cell based assays into HTS. I am interested in identifying the active substances as potential drugs. I am experienced in liquid handling and robotic automation. Previously I was working in a field of mutagenesis and carcinogenesis at Cancer Reasearch Institute in Bratislava.

Specializing in cellular stresses and their link to cancer development and treatment. Another specialization includes advanced microscopic techniques (the head of the bioimaging core facility: https://imtm.cz/core-facilities/bioimaging-core-facility ). Actively participated in the research of more than 10 national and international projects. Published more than >40 original investigations and three patents, >3000 citations, H-index 24

I am studying molecular mechanisms that control DNA replication in normal and cancer cells. Specifically, I am interested in effects of clinically used PARP inhibitors on progression of replication forks. Understanding how PARP inhibitors regulate replication fork dynamics is critical to targeting and developing durable cancer therapies.

Positions for talented Master or PhD students interested in DNA replication and DNA repair are available. Feel free to contact me for detailed information.

https://imtm.cz/dna-replication-dynamics

My area of research was always within the grasp of the metabolomics field. After I studied biochemistry, I have been working at the University Hospital Olomouc and my PhD was focused on medical genetics – especially in the potential application of untargeted metabolomics tools in clinical practice as a diagnostic tool. During my first internship at the University of Barcelona (Barcelona, Spain) I have learnt how to work with cell cultures and various techniques in molecular biology. During my second internship in San Jose (CA, USA) at Thermo Fisher Scientific, I got advanced skills and training in Orbitrap-based mass spectrometers and software. I see the metabolomics great potential as a ‘universal’ diagnostic tool in personalised medicine. In my opinion, the first signs can already be seen e.g. as use of the iKnife or in the improvement in new-born screening across the world. As a part of a great team of the scientists of Phenome Centre Birmingham, I was able to participate in many projects which helped me to get deeper insights in cooperation between academia and commercial subjects (industry). Now I have returned to my alma mater to the Palacký University where I want to continue my research. In future, I would like to focus my efforts on the study of the oxidative stress on the metabolite level. I would like to transfer more of lipidomics research into clinical practice. In my opinion, lipidomics approach has a great diagnostic potential for clinicians and there are still many undiscovered research opportunities.

Junior researcher working on:

- Proteomics

- Liquid chromatography / mass spectrometry applications

- Lipidomics

Researcher experienced in the field of Nuclear Medicine with the main research interest in the preclinical development of radiolabelled agents for molecular imaging. He is a holder of European specialisation certificate in radiopharmacy; National coordinator of Imaging and Tracing platform for European Translational Medicine Infrastructure (EATRIS); actively participated in several national and international research projects. Published >50 scientific papers, >150 abstracts, >1250 SCI citations, H-index 20.

Publication list: http://publicationslist.org/milospetrik

Orcid: https://orcid.org/0000-0003-1334-5916

I'm a chemoinformatician mainly involved in medicinal chemistry projects of development of new drugs. Author of approaches and open-source software for:

• representation of chemical compounds, their mixtures, quasi-mixtures and chemical reactions for modeling purposes;
• interpretation of QSAR models to retrieve SAR knowledge and use for drug design;
• 3D pharmacophore hashes, ligand-based and MD-based pharmacophore modeling;
• de novo structure generation;
• multi-instance learning.

Author of 5 book chapters and more than 50 journal papers. 

Research interests: Medicinal and bioorganic chemistry, molecular and drug design, chemoinformatics, machine learning and data mining, programming.

Web-site: http://qsar4u.com

Head of Animal Facility

Work experience with laboratory animals: mice, rats, and piglets.

Václav Ranc received his Ph.D. degree in analytical chemistry in 2009 from the Department of Analytical chemistry, Palacky University in Olomouc, Czech Republic under a supervision of Prof. Karel Lemr. He was then employed at the Department of Analytical chemistry, Palacky University, Olomouc as an assistant professor from 2008 to 2010. In 2011, he joined the team of prof. Rainer at the department of medicine at the University of Fribourg in Switzerland as a research scientist. He worked there from 2011-2012. He has worked as a reseacher at Palacký University since 2012.

He has authored or co-authored 66 scientific publications; H index = 24. He is a co-author of 2 international patents. His research activities are directed towards development of nano-sensors based on the utilization of Surface enhanced Raman spectroscopy and electrochemistry, and synthesis of functionalized nanomaterials.

Scientist and medical professional mainly involved in molecular and translational medicine (disease area paediatric, oncology and medical genetics). Experienced in project management and certification processes, involved as investigator in more than 20 national and international projects, co-founder of spin-off company focused on manufacturing of molecular diagnostics. 
Published more than >45 papers, >4books/chapters, >2 patents,  >260 oral/poster presentations, >710 SCI citations, H-index 11

Specialties: 
Molecular and translational medicine
Pediatrics, Oncology and Medical Genetics
Circulating tumor cells detection
Molecular profilling of tumors
Prognostic, predictive and diagnostic biomarkers

Responsibility for transcriptomic sequencing, circulating tumor cells detection, PCR based methods, gene expression profiling, SNP and CNV arrays. Biostatistical analyses. Biomedical project coordinator. Quality manager (ISO 15189). Teaching and examination of students, tutor for Bc., MSc. and PhD. students.

My current interest is medicinal chemistry, especially natural products with various biological activities. Our research consists of organic synthesis, evaluation of activities and mechanism of action. Earlier in my career, I was also involved in nucleic acid research, enzymology and biochemistry in general. In addition, I teach classes on bioorganic chemistry, chemical biology, and chemistry of nucleic acids.

ORCID: http://orcid.org/0000-0002-8249-028X 

Researcher ID: C-9611-2010 

I am a statistician with years of experience in statistical analysis of various types of data. My main interest is to statistically solve biomedical problems from preparation phase through laboratory experiments up to clinical trials evaluation.