Anzenbacher Pavel D.Sc.

Academic Title: Prof.
Phone: +420 585632569
Curriculum Vitae: download here

It is not easy to say something about myself. Just that I am proud of working here, just to mention - many colleagues from other labs in CZ express their admiration for  things which were achieved in Olomouc. It is however a commitment for future. Now we are trying to get as much information about systems we study as possible, using powerful instruments available here.

Publications (Impact Factor Journals)

  • [22]
    HYRSOVA, L., A. VANDUCHOVÁ, J. DUSEK, T. SMUTNY, A. CARAZO, V. MARESOVA, F. TREJTNAR, P. BARTA, P. ANZENBACHER, Z. DVORAK a P. PAVEK. Trans-resveratrol, but not other natural stilbenes occurring in food, carries the risk of drug-food interaction via inhibition of cytochrome P450 enzymes or interaction with xenosensor receptors. Toxicology Letters. 2019, 300, 81-91. ISSN 0378-4274. IF: 3.166. PMID: 30394306
  • [21]
    VANDUCHOVÁ, A., P. ANZENBACHER a E. ANZENBACHEROVÁ. Isothiocyanate from Broccoli, Sulforaphane, and Its Properties. Journal of Medicinal Food. 2018, 22(2), 121-126. ISSN 1096-620X. IF: 1.954. PMID: 30372361
  • [20]
    KRASULOVÁ, K., Z. DVORAK a P. ANZENBACHER. In vitro analysis of itraconazole cis-diastereoisomers inhibition of nine cytochrome P450 enzymes: stereoselective inhibition of CYP3A. Xenobiotica. 2018, 49(1), 36-42. ISSN 0049-8254. IF: 1.932. PMID: 29320899
  • [19]
    KRASULOVÁ, K., O. HOLAS a P. ANZENBACHER. Influence of Amlodipine Enantiomers on Human Microsomal Cytochromes P450: Stereoselective Time-Dependent Inhibition of CYP3A Enzyme Activity. Molecules. 2017, 22(11), pii: E1879. ISSN 1420-3049. IF: 2.861. PMID: 29099769
  • [18]
    NGUYEN, L., Z. MYSLIVECKOVA, B. SZOTAKOVA, A. ŠPIČÁKOVÁ, K. LNĚNIČKOVÁ, M. AMBROZ, V. KUBICEK, K. KRASULOVÁ, P. ANZENBACHER a L. SKALOVA. The inhibitory effects of β-caryophyllene, β-caryophyllene oxide and α-humulene on the activities of the main drug-metabolizing enzymes in rat and human liver in vitro. Chemico-biological Interactions. 2017, 278, 123-128. ISSN 0009-2797. IF: 3.143. PMID: 29074051
  • [17]
    ŠPIČÁKOVÁ, A., B. SZOTAKOVA, D. DIMUNOVA, Z. MYSLIVECKOVA, V. KUBICEK, M. AMBROZ, K. LNĚNIČKOVÁ, K. KRASULOVÁ, P. ANZENBACHER a L. SKALOVA. Nerolidol and Farnesol Inhibit Some Cytochrome P450 Activities but Did Not Affect Other Xenobiotic-Metabolizing Enzymes in Rat and Human Hepatic Subcellular Fractions. Molecules. 2017, 22(4), pii: E509. ISSN 1420-3049 . IF: 2.465. PMID: 28338641
  • [16]
    JOUROVA, L., P. ANZENBACHER, B. LIŠKOVÁ, Z. RÁCOVÁ (MATUŠKOVÁ), P. HERMANOVA, T. HUDCOVIC, H. KOZAKOVA, L. HRNCIROVA a E. ANZENBACHEROVÁ. Colonization by non-pathogenic bacteria alters mRNA expression of cytochromes P450 in originally germ-free mice. Folia Microbiologica. 2017, 62(6), 463-469. ISSN 0015-5632 . IF: 1.335. PMID: 28337589
  • [15]
    STEPANKOVA, M., K. KRASULOVÁ, A. DORCICAKOVA, O. KURKA, P. ANZENBACHER a Z. DVORAK. Optical isomers of dihydropyridine calcium channel blockers display enantiospecific effects on the expression and enzyme activities of human xenobiotics-metabolizing cytochromes P450. Toxicology Letters. 2016, 16(262), 173-186. ISSN 0378-4274 . IF: 3.858. PMID: 27732883
  • [14]
    KOPECNA ZAPLETALOVA, M., K. KRASULOVÁ, P. ANZENBACHER, J. HODEK a E. ANZENBACHEROVÁ. Interaction of isoflavonoids with human liver microsomal cytochromes P450: inhibition of CYP enzyme activities. Xenobiotica. 2016, 47(4), 324-331. ISSN 0049-8254. IF: 1.932. PMID: 27312150
  • [13]
    RÁCOVÁ (MATUŠKOVÁ), Z., P. ANZENBACHER, R. VECERA, M. ŠILLER, H. TLASKALOVA-HOGENOVA, J. STROJIL a E. ANZENBACHEROVÁ. Effect of Lactobacillus casei on the Pharmacokinetics of Amiodarone in Male Wistar Rats. European Journal of Drug Metabolism and Pharmacokinetics. 2017, 42(1), 29-36. ISSN 0378-7966. IF: 1.680. PMID: 26797809
  • [12]
    NEKVINDOVA, J., J.A. CONTRERAS, P. JUVAN, K.F. TACER, P. ANZENBACHER, Z. ZIDEK, M. KOPECNA ZAPLETALOVA, D. ROZMAN a E. ANZENBACHEROVÁ. Acyclic nucleoside phosphonates: a study on cytochrome P450 gene expression. Xenobiotica. 2014, 44(8), 708-715. ISSN 0049-8254. IF: 2.199. PMID: 24593268
  • [11]
    RÁCOVÁ (MATUŠKOVÁ), Z., E. ANZENBACHEROVÁ, R. VECERA, H. TLASKALOVA-HOGENOVA, M. KOLÁŘ a P. ANZENBACHER. Administration of a probiotic can change drug pharmacokinetics: effect of E. coli Nissle 1917 on amidarone absorption in rats. PLOS One. 2014, 9(2), e87150. ISSN 1932-6203. IF: 3.234. PMID: 24505278
  • [10]
    SROVNALOVA, A., M. SVECAROVA, M. KOPECNA ZAPLETALOVA, P. ANZENBACHER, P. BACHLEDA, E. ANZENBACHEROVÁ a Z. DVORAK. Effects of Anthocyanidins and Anthocyanins on the Expression and Catalytic activities of CYP2A6, CYP2B6, CYP2C9, and CYP3A4 in primary human hepatocytes and human liver microsomes. Journal of Agricultural and Food Chemistry. 2014, 62(3), 789-797. ISSN 0021-8561. IF: 2.912. PMID: 24387788
  • [9]
    BERKA, K., E. ANZENBACHEROVÁ, T. HENDRYCHOVA, R. LANGE, V. MAŠEK, P. ANZENBACHER a M. OTYEPKA. Binding of quinidine radically increases the stability and decreases the flexibility of the cytochrome P450 2D6 active site. Journal of Inorganic Biochemistry. 2012, 110(-), 45-60. ISSN 0162-0134. IF: 3.197. PMID: 22459173
  • [8]
    HENDRYCHOVA, T., K. BERKA, V. NAVRATILOVA, P. ANZENBACHER a M. OTYEPKA. Dynamics and hydration of the active sites of mammalian cytochromes P450 probed by molecular dynamics simulations. Current Drug Metabolism. 2012, 13(2), 177-189. ISSN 1389-2002. IF: 4.405. PMID: 22208532
  • [7]
    OTYEPKA, M., K. BERKA a P. ANZENBACHER. Is there a relationship between the substrate preferences and structural flexibility of cytochromes P450?. Current Drug Metabolism. 2012, 13(2), 130-142. ISSN 1389-2002. IF: 4.405. PMID: 22208528
  • [6]
    RÁCOVÁ (MATUŠKOVÁ), Z., M. ŠILLER, A. TUNKOVA, E. ANZENBACHEROVÁ, A. ZACHAROVA, H. TLASKALOVA-HOGENOVA, Z. ZIDEK a P. ANZENBACHER. Effects of Lactobacillus casei on the expression and the activity of cytochromes P450 and on the CYP mRNA level in the intestine and the liver of male rats. Neuroendocrinology Letters. 2011, 32(suppl.1), 8-14. ISSN 0172-780X. IF: 1.296. PMID: 22167211
  • [5]
    ŠILLER, M., P. ANZENBACHER, E. ANZENBACHEROVÁ, K. DOLEZAL a M. STRNAD. In vitro interaction of a novel neutrophil growth factor with human liver microsomal cytochromes P450 and the contribution of UDP-glucuronosyltransferases to metabolism. Xenobiotica. 2011, 41(11), 934-944. ISSN 0049-8254. IF: 1.791. PMID: 21745145
  • [4]
    BERKA, K., T. HENDRYCHOVA, P. ANZENBACHER a M. OTYEPKA. Membrane position of ibuprofen agrees with suggested access path entrance to cytochrome P450 2C9 active site. Journal of Physical Chemistry A. 2011, 115(41), 11248-11255. ISSN 1089-5639. IF: 2.946. PMID: 21744854
  • [3]
    MAŠEK, V., E. ANZENBACHEROVÁ, T. ETRYCH, J. STROHALM, K. ULBRICH a P. ANZENBACHER. Interaction of N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin conjugates with human liver microsomal cytochromes P450: Comparison with free doxorubicin. Drug Metabolism and Disposition. 2011, 39(9), 1704-1710. ISSN 0090-9556. IF: 3.733. PMID: 21642392
  • [2]
    JANČOVÁ, P., M. ŠILLER, E. ANZENBACHEROVÁ, V. KREN, P. ANZENBACHER a V. ŠIMÁNEK. Evidence for differences in regioselective and stereoselective glucuronidation of silybin diastereomers from milk thistle (Silybum marianum) by human UDP-glucuronosyltransferases. Xenobiotica. 2011, 41(9), 743-751. ISSN 0049-8254. IF: 1.791. PMID: 21524189
  • [1]
    HENDRYCHOVA, T., E. ANZENBACHEROVÁ, J. HUDECEK, J. SKOPALIK, R. LANGE, P. HILDEBRANDT, M. OTYEPKA a P. ANZENBACHER. Flexibility of human cytochrome P450 enzymes: Molecular dynamics and spectroscopy reveal important function-related variation. Biochimica et Biophysica Acta-Proteins and Proteomics. 2011, 1814(1), 58-68. ISSN 1570-9639. IF: 3.635. PMID: 20656072
  • Publications (Other Reviewed Journals)

  • [2]
    RÁCOVÁ (MATUŠKOVÁ), Z., M. PORUBA a P. ANZENBACHER. Cytochromy P450: Role v metabolizmu cholesterolu. Klinická farmakologie. 2014, 28(4), 142-126. ISSN 1212-7973.
  • [1]
    ANZENBACHER, P. a J. NEKVINDOVA. Perzonalizovaná medicína - současná praxe a přísliby do budoucna. Klinická farmakologie a farmacie. 2012, 26(3), 123-125. ISSN 1212-7973.

  • Doctoral students mentor:

    [3] Kristýna Krasulová, Studium interakcí léčiv s enzymy metabolismu cizorodých látek. ,
    Ph.D. specialization: , status: Graduated, from: 2013 to 2017
    [2] Alena Špičáková, Drug interactions with nutraceuticals level metabolism,
    Ph.D. specialization: , status: Ongoing, from: 2012
    [1] Zuzana Rácová (Matušková), Cytochromes P450 - main enzymes in drug metabolism: Study of properties of these enzymes in rat gastrointestinal tract and their influence by probiotics,
    Ph.D. specialization: , status: Graduated, from: 2008 to 2015