Doctoral training
Identification and Characterisation of Tau Minimal Regions as Potential Pharmacological Targets Against Tau Spreading in Tauopathies.
Understanding the mechanisms of tau aggregation, propagation and cellular machinery involved in aggregated tau degradation would help identify therapeutic targets for tauopathies (Alzheimer’s disease, PSP, CTE, FTLD, etc.) and other neurodegenerative diseases. The thesis is focused on studying tau aggregate spreading mechanisms and identifying small molecule inhibitors of tau misfolding and aggregation using in vitro aggregation assays, cell and molecular biology, biochemistry and microscopy techniques. I am also working on validating small molecules (selected from in vitro MARK4 kinase activity inhibition assay) on inhibiting microtubule affinity regulating kinase 4 (MARK4) mediated tau phosphorylation using a cell line model.
About me
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