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Annadurai Narendran M.Sc.

Phone: +420 775 094 851
Groups: Staff, LEM, Doctoral Student

Doctoral training

Tau aggregation inhibitors for the treatment of neurodegenerative diseases.

Understanding the mechanisms of tau aggregation, propagation and cellular machinery involved in aggregated tau degradation would help in identifying therapeutic targets for tauopathies (Alzheimer’s disease, PSP, CTE, FTLD, etc.) and other neurodegenerative diseases. The thesis is focused on studying tau aggregate spreading mechanisms, identifying small molecule inhibitors of tau misfolding and aggregation using in vitro aggregation assays, cell and molecular biology, biochemistry and microscopy techniques. I am also working on the validation of small molecules (selected from in vitro MARK4 kinase activity inhibition assay) on inhibiting microtubule affinity regulating kinase 4 (MARK4) mediated tau phosphorylation using a cell line model.

Specialization: Pediatrics.
Status: Ongoing from 2015.

About me

I earned my M.Sc. in Biotechnology from St. Joseph’s College, Tiruchirappalli, India. I worked as a Project Assistant at divisions of Toxicology and Microbiology, CSIR-Central Drug Research Institute (CDRI), Lucknow, India and as a Visiting Researcher at the Department of Infection, Immunity and Inflammation, University of Leicester, United Kingdom. I joined IMTM, Olomouc in 2015 and I am interested in understanding the molecular mechanisms of protein (tau, α-synuclein) aggregation and its propagation. Outside of research, I enjoy reading science fiction books, photography and a Numismatist. 
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