E-mail: Narendran.Annadurai01@upol.cz
Phone: +420 775 094 851
Understanding the mechanism of tau aggregation, propagation and cellular machinery involved in aggregated tau degradation would help in identifying therapeutic targets for tauopathies (Alzheimer’s disease, PSP, CTE, FTLD, etc.) and other neurodegenerative diseases. The thesis is focused on studying tau aggregate spreading mechanisms, identifying small molecule inhibitors of tau misfolding and aggregation using in vitro aggregation assays, cell biology, biochemistry and microscopy techniques.
Publications (Impact Factor Journals)
[3]
ŘEHULKA, J., N. ANNADURAI, I. FRYDRYCH, P. DŽUBÁK, M. MILLER, M. HAJDÚCH a V. DAS.
Peloruside A-Induced Cell Death in Hypoxia Is p53 Dependent in HCT116 Colorectal Cancer Cells.
Journal of Natural Products.
2018,
81(3),
634-640.
ISSN 0163-3864.
IF: 3.281.
PMID:
29400463
[2]
ANNADURAI, N., K. AGRAWAL, P. DŽUBÁK, M. HAJDÚCH a V. DAS.
Microtubule affinity-regulating kinases are potential druggable targets for Alzheimer's disease.
Cellular and Molecular Life Sciences.
2017,
74(22),
4159-4169.
ISSN 1420-682X.
IF: 5.788.
PMID:
28634681
[1]
ŘEHULKA, J., N. ANNADURAI, I. FRYDRYCH, P. ZNOJEK, P. DŽUBÁK, P. NORTHCOTE, J.H. MILLER, M. HAJDÚCH a V. DAS.
Cellular effects of the microtubule-targeting agent peloruside A in hypoxia-conditioned colorectal carcinoma cells.
Biochimica et Biophysica Acta.
2017,
17,
30124-1.
ISSN 0304-4165.
IF: 5.083.
PMID:
28366502
Bachelor students mentor:
[1] Jiří Hrubý, Studying the role of tunneling nanotubes in cell-to-cell transfer of tau aggregates: Implications in tauopathies,
status: Ongoing, from: 2018
status: Ongoing, from: 2018