Vrba Jiří Ph.D.

Academic Title: Mgr.
Curriculum Vitae: download here

Publications (Impact Factor Journals)

  • [12]
    VRBA, J., L. ROUBALOVÁ, V. CIRKVA, J. STORCH a J. VACEK. Cytotoxicity of hexahelicene and its effect on the aryl hydrocarbon receptor pathway. Toxicology In Vitro. 2019, 57, 105-109. ISSN 0887-2333. IF: 3.105. PMID: 30822459
  • [11]
    VALENTOVA, K., K. PURCHARTOVA, L. RYDLOVA, L. ROUBALOVÁ, D. BIEDERMANN, L. PETRASKOVA, A. KRENKOVA, H. PELANTOVA, V. HOLECKOVA-MORAVCOVA, E. TESAROVA, J. CVACKA, J. VRBA, J. ULRICHOVÁ a V. KREN. Sulfated Metabolites of Flavonolignans and 2,3-Dehydroflavonolignans: Preparation and Properties. International Journal of Molecular Sciences. 2018, 19(8), pii: E2349. ISSN 1422-0067. IF: 3.687. PMID: 30096957
  • [10]
    ROUBALOVÁ, L., A. DINKOVA-KOSTOVA, D. BIEDERMANN, V. KREN, J. ULRICHOVÁ a J. VRBA. Flavonolignan 2,3-dehydrosilydianin activates Nrf2 and upregulates NAD(P)H:quinone oxidoreductase 1 in Hepa1c1c7 cells. Fitoterapia. 2017, 119, 115-120. ISSN 0367-326X. IF: 2.408. PMID: 28450126
  • [9]
    VRÁNA, D., M. MATZENAUER, R. AUJESKY, J. VRBA, C. NEORAL, B. MELICHAR a P. SOUCEK. Potential Predictive Role of MicroRNAs in the Neoadjuvant Treatment of Esophageal Cancer. Anticancer Research. 2017, 37(2), 403-4012. ISSN 0250-7005 . IF: 1.895. PMID: 28179285
  • [8]
    ROUBALOVÁ, L., D. BIEDERMANN, B. PAPOUSKOVA, J. VACEK, M. KUZMA, V. KREN, J. ULRICHOVÁ, A. DINKOVA-KOSTOVA a J. VRBA. Semisynthetic flavonoid 7-O-galloylquercetin activates Nrf2 and induces Nrf2-dependent gene expression in RAW264.7 and Hepa1c1c7 cells. Chemico-biological Interactions. 2016, 2016, 58-66. ISSN 0009-2797 . IF: 3.143. PMID: 27777014
  • [7]
    ROUBALOVÁ, L., K. PURCHARTOVA, B. PAPOUSKOVA, J. VACEK, V. KREN, J. ULRICHOVÁ a J. VRBA. Sulfation modulates the cell uptake, antiradical activity and biological effects of flavonoids in vitro: An examination of quercetin, isoquercitrin and taxifolin. Bioorganic and Medicinal Chemistry. 2015, 23(17), 5402-5409. ISSN 0968-0896 . IF: 2.923. PMID: 26260337
  • [6]
    VRBA, J., M. HAVLIKOVA, D. GERHARDOVA a J. ULRICHOVÁ. Palmatine activates AhR and upregulates CYP1A activity in HepG2 cells but not in human hepatocytes. Toxicology in Vitro. 2014, 28(-), 693-699. ISSN 0887-2333. IF: 2.903. PMID: 24583342
  • [5]
    VRBA, J., R. GAZAK, M. KUZMA, B. PAPOUSKOVA, J. VACEK, M. WEISZENSTEIN, V. KREN a J. ULRICHOVÁ. A Novel Semisynthetic Flavonoid 7‑O‑Galloyltaxifolin Upregulates Heme Oxygenase‑1 in RAW264.7 Cells via MAPK/Nrf2 Pathway. Journal of Medicinal Chemistry. 2013, 56(3), 856-866. ISSN 0022-2623. IF: 5.480. PMID: 23294286
  • [4]
    VRBA, J., K. TRTKOVA a J. ULRICHOVÁ. HDAC inhibitors sodium butyrate and sodium valproate do not affect human NCOR1 and NCOR2 gene expression in HL-60 cells. Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czech Republic. 2011, 155(3), 259-262. ISSN 1213-8118. IF: 0.702. PMID: 22286811
  • [3]
    VRBA, J., E. OROLINOVA a J. ULRICHOVÁ. Induction of heme oxygenase-1 by Macleaya cordata extract and its constituent sanguinarine in RAW264.7 cells. Fitoterapia. 2012, 83(2), 329-335. ISSN 0367-326X. IF: 2.231. PMID: 22166397
  • [2]
    VRBA, J., E. VRUBLOVA, M. MODRIANSKÝ a J. ULRICHOVÁ. Protopine and allocryptopine increase mRNA levels of cytochromes P450 1A in human hepatocytes and HepG2 cells independently of AhR. Toxicology Letters. 2011, 203(2), 135-141. ISSN 0378-4274. IF: 3.230. PMID: 21419197
  • [1]
    VRBA, J., B. PAPOUSKOVA, L. ROUBALOVÁ, M. ZATLOUKALOVA, D. BIEDERMANN, V. KREN, K. VALENTOVA, J. ULRICHOVÁ a J. VACEK. Metabolism of flavonolignans in human hepatocytes. Journal of Pharmaceutical and Biomedical Analysis. 2018, 152, 94-101. ISSN 0731-7085. IF: 3.225.

  • Doctoral students mentor:

    [1] Lenka Roubalová, Molecular mechanisms of the protective effect of natural substances,
    Ph.D. specialization: , status: Ongoing, from: 2013