Hajdúch Marián M.D., Ph.D.

Hajdúch Marián M.D., Ph.D.'s picture
Academic Title: Associate Professor
Phone: +420 585632082, +420 585632083
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Scientist and medical professional mainly involved in molecular and translational medicine (disease area oncology and infectious diseases); long-term experience in project management; R&D and technology transfer activities, including the construction and management of large research infrastructures. He has been involved as principal investigator, investigator or clinical site manager in 12 clinical trials; actively participated in the research and/or management of more than 40 national and international projects; established major cancer research foundation in the country; spin-off company focused on manufacturing of molecular diagnostics; Chair of the Boards of National Director and Czech National Director for European Translational Medicine Infrastructure (EATRIS); participated in creation of national network for personalized medicine and cancer management policies. Published more than >200 papers, 12 books/chapters, >23 patents, >1200 SCI citations, H-index 23.


Publications (Impact Factor Journals):

  • [179]
    USSI, A.E., M. REBOLI, M. THORAT, F. BIETRIX, A. FAUVEL, M. HAJDÚCH, C. HILL, I. WALKER, M. VAN ENGLAND, J. CUZICK a G. MEIJER. Letter to the editor: Assessing opportunities for coordinated R&D in early cancer detection and management in Europe. International Journal of Cancer. 2016, 140, 1700-1701. ISSN 0020-7136 . IF: 6.513. PMID: 279432650
  • [178]
    JURÁŠEK, M., M. CERNOHORSKA, J. ŘEHULKA, V. SPIWOK, T. SULIMENKO, E. DRABEROVA, M. DARMOSTUK, S. GURSKÁ, I. FRYDRYCH, R. BURIÁNOVÁ, T. RUML, M. HAJDÚCH, P. BARTŮNĚK, P. DRABER, P. DŽUBÁK, P. DRAŠAR a D. SEDLÁK. Estradiol Dimer Inhibits Tubulin Polymerization and Microtubule Dynamics. The Journal of Steroid Biochemistry and Molecular Biology. 2018, -, -. ISSN 0960-0760. IF: 4.561. PMID: 29803726
  • [177]
    MRAZKOVA, B., R. DZIJAK, T. IMRICHOVA, L. KYJACOVA, P. BARATH, P. DŽUBÁK, D. HOLUB, M. HAJDÚCH, Z. NAHACKA, L. ANDERA, P. HOLICEK, P. VASICOVA a O. SAPEGA. Induction, regulation and roles of neural adhesion molecule L1CAM in cellular senescence. Aging. 2018, 10(3), 432-462. ISSN 1945-4589. IF: 4.867. PMID: 29615539
  • [176]
    URBANOVSKÁ, I., M. HOUDOVÁ MEGOVÁ , Z. DWIGHT, O. KALITA, M. UVÍROVÁ, J. SIMOVA, L. TUČKOVÁ, P. BUZRLA, T. PALECEK, M. HAJDÚCH, J. DVORACKOVA a J. DRÁBEK. IDH Mutation Analysis in Glioma Patients by CADMA Compared with SNaPshot Assay and two Immunohistochemical Methods. Pathology & Oncology Research. 2018, -, -. ISSN 1219-4956. IF: 1.736. PMID: 29556922
  • [175]
    TULPOVA, Z., M. LUO, H. TOEGELOVA, P. VISENDI, S. HAYASHI, P. VOJTA, E. PAUX, A. KILIAN, M. ABROUK, J. BARTOS, M. HAJDÚCH, J. BATLEY, D. EDWARDS, J. DOLEZEL a H. SIMKOVA. Integrated physical map of bread wheat chromosome arm 7DS to facilitate gene cloning and comparative studies. New Biotechmology. 2018, -, -. ISSN 1871-6784. IF: 3.813. PMID: 29526810
  • [174]
    BÜRGLOVÁ, K., G. RYLOVÁ, A. MARKOS, H. PŘICHYSTALOVÁ, M. SOURAL, M. PETRÁČEK, M. MEDVEDÍKOVÁ, G. TEJRAL, B. SOPKO, P. HRADIL, P. DŽUBÁK, M. HAJDÚCH a J. HLAVÁČ. Identification of Eukaryotic Translation Elongation Factor 1-α 1 Gamendazole-Binding Site for Binding of 3-Hydroxy-4(1 H)-quinolinones as Novel Ligands with Anticancer Activity. Journal of Medicinal Chemistry. 2018, -, -. ISSN 0022-2623. IF: 6.259. PMID: 29498519
  • [173]
    VOLEJNÍKOVÁ, J., J. ZAPLETALOVA, M. JAROSOVA, H. URBANKOVA, E. KLASKOVA, M. HOROWITZ, M. HAJDÚCH a V. MIHÁL. Acute lymphoblastic leukemia in a child with Leri-Weill syndrome and complete SHOX gene deletion: A Case Report. Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czech Republic. 2018, -, -. ISSN 1213-8118. IF: 0.894. PMID: 29469136
  • [172]
    CHYRA KUFOVA, Z., T. SEVCIKOVA, J. JANUSKA, P. VOJTA, A. BODAY, P. VANICKOVA, J. FILIPOVA, K. GROWKOVA, T. JELINEK, M. HAJDÚCH a R. HAJEK. Newly designed 11-gene panel reveals first case of hereditary amyloidosis captured by massive parallel sequencing. Journal of Clinical Pathology. 2018, -, -. ISSN 0021-9746. IF: 2.687. PMID: 29455155
  • [171]
    AGRAWAL, K., V. DAS, P. VYAS a M. HAJDÚCH. Nucleosidic DNA demethylating epigenetic drugs - A comprehensive review from discovery to clinic. Pharmacology & Therapeutics. 2018, -, -. ISSN 0163-7258. IF: 11.127. PMID: 29454856
  • [170]
    FLODROVÁ, P., P. FLODR, T. PIKA, J. VYMETAL, D. HOLUB, P. DŽUBÁK, M. HAJDÚCH a V. SCUDLA. Cardiac amyloidosis: from clinical suspicion to morphological diagnosis. Pathology. 2018, -, -. ISSN 0031-3025. IF: 2.709. PMID: 29448998
  • [169]
    POKORNÝ, J., S. KRAJČOVIČOVÁ, M. HAJDÚCH, M. HOLOUBEK, S. GURSKÁ, P. DŽUBÁK, T. VOLNÁ, I. POPA a M. URBAN. Triterpenic azines, a new class of compounds with selective cytotoxicity to leukemia cells CCRF-CEM. Future Medicinal Chemistry. 2018, 10(5), 483-491. ISSN 1756-8919. IF: 3.566. PMID: 29424548
  • [168]
    KRAJČOVIČOVÁ, S., J. STANKOVÁ, P. DŽUBÁK, M. HAJDÚCH, M. SOURAL a M. URBAN. A Synthetic Approach for the Rapid Preparation of BODIPY Conjugates and their use in Imaging of Cellular Drug Uptake and Distribution. Chemistry- A European Journal. 2018, 24(19), 4957-4966. ISSN 0947-6539. IF: 5.317. PMID: 29411907
  • [167]
    ŘEHULKA, J., N. ANNADURAI, I. FRYDRYCH, P. DŽUBÁK, M. MILLER, M. HAJDÚCH a V. DAS. Peloruside A-Induced Cell Death in Hypoxia Is p53 Dependent in HCT116 Colorectal Cancer Cells. Journal of Natural Products. 2018, -, -. ISSN 0163-3864. IF: 3.281. PMID: 29400463
  • [166]
    SESTAK, S., M. BELLA, T. KLUNDA, S. GURSKÁ, P. DŽUBÁK, F. WÖLS, I. WILSON, V. SLADEK, M. HAJDÚCH, M. POLÁKOVÁ a J. KONA. N-Benzyl Substitution of Polyhydroxypyrrolidines: The Way to Selective Inhibitors of Golgi α-Mannosidase II. ChemMedChem. 2018, 13(4), 373-383. ISSN 1860-7179. IF: 3.225. PMID: 29323461
  • [165]
    ŠKROTT, Z., M. MISTRÍK, K. ANDERSEN, S. FRIIS, D. MAJERA, J. GURSKÝ, T. OŽDIAN, J. BARTKOVA, Z. TURI, P. MOUDRÝ, M. KRAUS, M. MEDVEDÍKOVÁ, J. VÁCLAVKOVÁ, P. DŽUBÁK, I. VROBEL, P. POUCKOVA, J. SEDLACEK, A. MIKLOVICOVA, A. KUTT, J. MATTOVA, C. DRIESSEN, Q. DOU, J. OLSEN, M. HAJDÚCH, B. CVEK, R. DESHAIES a J. BÁRTEK. Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4. Nature. 2017, 552(7684), 194-199. ISSN 0028-0836. IF: 40.137. PMID: 29211715
  • [164]
    EIGNEROVA, B., M. TICHÝ, J. KRASULOVA, L. RAROVA, R. CHRISTOVÁ, M. URBAN, B. BEDNARCZYK-CWYNAR, M. HAJDÚCH a J. ŠAREK. Q1_Synthesis and antiproliferative properties of new hydrophilic esters of triterpenic acids. European Journal of Medicinal Chemistry. 2017, 140, 403-420. ISSN 0223-5234. IF: 4.519. PMID: 28987603
  • [163]
    USSI, A.E., M. DE KORT, N.P. COUSSENS, T. AITTOKALLIO a M. HAJDÚCH. In Search of System-Wide Productivity Gains - The Role of Global Collaborations in Preclinical Translation. Clinical and Translational Science. 2017, 10(6), 423-425. ISSN 1752-8054. IF: 0.860. PMID: 28929592
  • [162]
    CAMATEROS, P., C. KANAGARATHAM, L. NAJDEKR, D. HOLUB, J. VRBKOVÁ, L. COTE, J. FOURNIER, J. GOURDON, D. CREERY, R. OLIVENSTEIN, F. KOPŘIVA, T. ADAM, D. FRIEDECKÝ, P. DŽUBÁK, M. HAJDÚCH a D. RADZIOCH. TLR 7/8 Ligand, S28463, Suppresses Ascaris Suum Induced Allergic Asthma in Nonhuman Primates. American Journal of Respiratory Cell and Molecular Biology. 2017, 58(1), 55-65. ISSN 1044-1549. IF: 4.100. PMID: 28850259
  • [161]
    GARIC, D., J.B. DE SANCTIS, G. WOJEWODKA, D. HOULE, S. CUPRI, A. ABU-ARISH, J. HANRAHAN, M. HAJDÚCH, E. MATOUK a D. RADZIOCH. Fenretinide differentially modulates the levels of long- and very long-chain ceramides by downregulating Cers5 enzyme: evidence from bench to bedside. Journal of Molecular Medicine. 2017, 95(10), 1053-1064. ISSN 0946-2716. IF: 4.686. PMID: 28695226
  • [160]
    ANNADURAI, N., K. AGRAWAL, P. DŽUBÁK, M. HAJDÚCH a V. DAS. Microtubule affinity-regulating kinases are potential druggable targets for Alzheimer's disease. Cellular and Molecular Life Sciences. 2017, 74(22), 4159-4169. ISSN 1420-682X. IF: 5.788. PMID: 28634681
  • [159]
    NARDONE, G., J. OLIVER-DE LA CRUZ, J. VRBSKY, C. MARTINI, J. PRIBYL, P. SKLADAL, M. PESL, G. CALUORI, S. PAGLIARI, F. MARTINO, Z. MACEČKOVÁ, M. HAJDÚCH, A. SANZ-GARCIA, N. PUGNO, G. STOKIN a G. FORTE. YAP regulates cell mechanics by controlling focal adhesion assembly. Nature Communications. 2017, 15, 8:15321. ISSN 2041-1723. IF: 11.329. PMID: 28504269
  • [158]
    OŽDIAN, T., D. HOLUB, Z. MACEČKOVÁ, L. VARANASI, G. RYLOVÁ, J. ŘEHULKA, J. VÁCLAVKOVÁ, H. SLAVÍK, P. MOUDRÝ, P. ZNOJEK, J. STANKOVÁ, J.B. DE SANCTIS, M. HAJDÚCH a P. DŽUBÁK. Proteomic profiling reveals DNA damage, nucleolar and ribosomal stress are the main responses to oxaliplatin treatment in cancer cells. Journal of Proteomics. 2017, 162, 73-85. ISSN 1874-3919 . IF: 3.867. PMID: 28478306
  • [157]
    VAN GOOL, A., F. BIETRIX, E. CALDENHOVEN, K. ZATLOUKAL, A. SCHERER, J. LITTON, G. MEIJER, N. BLOMBERG, A. SMITH, B. MONS, J. HERINGA, W. KOOT, M. SMIT, M. HAJDÚCH, T. RIJNDERS a A.E. USSI. Bridging the translational innovation gap through good biomarker practice. Nature Reviews. Drug Discovery. 2017, 16(9), 587-588. ISSN 1474-1776 . IF: 57.000. PMID: 28450744
  • [156]
    ŘEHULKA, J., N. ANNADURAI, I. FRYDRYCH, P. ZNOJEK, P. DŽUBÁK, P. NORTHCOTE, J.H. MILLER, M. HAJDÚCH a V. DAS. Cellular effects of the microtubule-targeting agent peloruside A in hypoxia-conditioned colorectal carcinoma cells. Biochimica et Biophysica Acta. 2017, 17, 30124-1. ISSN 0304-4165. IF: 5.083. PMID: 28366502
  • [155]
    DAS, V., T. FÜRST, S. GURSKÁ, P. DŽUBÁK a M. HAJDÚCH. Evaporation-reducing Culture Condition Increases the Reproducibility of Multicellular Spheroid Formation in Microtiter Plates. Journal of Visualized Experiments. 2017, 121, doi: 10.3791/55403. ISSN 1940-087X. IF: 1.113. PMID: 28362402
  • [154]
    TICHÝ, M., S. SMOLEN, E. TLOUŠŤOVÁ, R. POHL, T. OŽDIAN, K. HEJTMÁNKOVÁ, B. LIŠKOVÁ, S. GURSKÁ, P. DŽUBÁK, M. HAJDÚCH a M. HOCEK. Synthesis and Cytostatic and Antiviral Profiling of Thieno-Fused 7-Deazapurine Ribonucleosides. Journal of Medicinal Chemistry. 2017, 60(6), 2411-2424. ISSN 0022-2623. IF: 5.589. PMID: 28221790
  • [153]
    ŠIDOVÁ, V., P. ZOUFALÝ, J. POKORNÝ, P. DŽUBÁK, M. HAJDÚCH, I. POPA a M. URBAN. Cytotoxic conjugates of betulinic acid and substituted triazoles prepared by Huisgen Cycloaddition from 30-azidoderivatives. PLOS One. 2017, 12(2), e0171621. ISSN 1932-6203 . IF: 3.057. PMID: 28158265
  • [152]
    VOLLER, J., T. BERES, M. ZATLOUKAL, P. KAMINSKI, P. NIEMANN, K. DOLEZAL, P. DŽUBÁK, M. HAJDÚCH a M. STRNAD. The natural cytokinin 2OH3MeOBAR induces cell death by a mechanism that is different from that of the "classical" cytokinin ribosides. Phytochemistry. 2017, 136, 156-164. ISSN 0031-9422 . IF: 2.779. PMID: 28153445
  • [151]
    BORKOVÁ, L., R. ADÁMEK, P. KALINA, P. DRAŠAR, P. DŽUBÁK, S. GURSKÁ, J. ŘEHULKA, M. HAJDÚCH, M. URBAN a J. ŠAREK. Synthesis and Cytotoxic Activity of Triterpenoid Thiazoles Derived from Allobetulin, Methyl Betulonate, Methyl Oleanonate, and Oleanonic Acid. ChemMedChem. 2017, 12(5), 390-398. ISSN 1860-7179 . IF: 2.980. PMID: 28084676
  • [150]
    AGRAWAL, K., V. DAS, M. OTMAR, M. KRECMEROVA, P. DŽUBÁK a M. HAJDÚCH. Cell-based DNA demethylation detection system for screening of epigenetic drugs in 2D, 3D, and xenograft models. Cytometry A. 2016, -, -. ISSN 1552-4922 . IF: 3.222. PMID: 27911980
  • [149]
    LITHWICK-YANAI, G., N. DROMI, A. SHTABSKY, S. MORGENSTERN, Y. STRENOV, M. FEINMESSER, V. KRAVTSOV, M. LEON, M. HAJDÚCH, S. ALI, C. VANDENBUSSCHE, C. ZHANG, L. LEIDER-TREJO, A. ZUBKOV, S. VOROBYOV, M. KUSHNIR, Y. GOREN, S. TABAK, E. KADOSH, H. BENJAMIN, T. SCHNITZER-PERLMAN, H. MARMOR, M. MOTIN, D. LEBANONY, S. KREDO-RUSSO, H. MITCHELL, M. NOLLER, A. SMITH, O. DATTNER, K. ASKHENAZI, M. SANDEN, K. BERLIN, D. BAR a E. MEIRI. Multicentre validation of a microRNA-based assay for diagnosing indeterminate thyroid nodules utilising fine needle aspirate smears. Journal of Clinical Pathology. 2017, 70(6), 500-507. ISSN 0021-9746 . IF: 2.912. PMID: 27798083
  • [148]
    KISS, I., J. MLCOCHOVA, Z. BORTLICEK, A. POPRACH, J. DRÁBEK, P. VYCHYTILOVA-FALTEJSKOVA, M. SVOBODA, T. BUCHLER, S. BATKO, A. RYSKA, M. HAJDÚCH a O. SLABÝ. Efficacy and Toxicity of Panitumumab After Progression on Cetuximab and Predictive Value of MiR-31-5p in Metastatic Wild-type KRAS Colorectal Cancer Patients. Anticancer Research. 2016, 36(9), 7955-9. ISSN 0250-7005 . IF: 1.937. PMID: 27630355
  • [147]
    SCHADICH, E., P. DŽUBÁK a M. HAJDÚCH. Role of Salmonella Typhi Vi Antigen and Secretory Systems on Immune Response. Current Pharmaceutical Design. 2016, 22(41), 6251-6260. ISSN 1381-6128. IF: 2.611. PMID: 27573929
  • [146]
    JURÁŠEK, M., P. DŽUBÁK, S. RIMPELOVA, D. SEDLÁK, P. KONEČNÝ, I. FRYDRYCH, S. GURSKÁ, M. HAJDÚCH, K. BOGDANOVÁ, M. KOLÁŘ, T. MÜLLER, E. KMONICKOVA, T. RUML, J. HARMATHA a P. DRAŠAR. Trilobolide-steroid hybrids: Synthesis, cytotoxic and antimycobacterial activity. Steroids. 2017, 117(2017), 97-104. ISSN 0039-128X. IF: 2.513. PMID: 27543674
  • [145]
    BORKOVÁ, L., S. GURSKÁ, P. DŽUBÁK, R. BURIÁNOVÁ, M. HAJDÚCH, J. ŠAREK, I. POPA a M. URBAN. Lupane and 18α-oleanane derivatives substituted in the position 2, their cytotoxicity and influence on cancer cells. European Journal of Medicinal Chemistry. 2016, 121, 120-131. ISSN 0223-5234 . IF: 4.519. PMID: 27236068
  • [144]
    DAS, V., T. FÜRST, S. GURSKÁ, P. DŽUBÁK a M. HAJDÚCH. Reproducibility of Uniform Spheroid Formation in 384-Well Plates: The Effect of Medium Evaporation. Journal of Biomolecular Screening. 2016, 21(9), 923-30. ISSN 1087-0571 . IF: 2.444. PMID: 27226477
  • [143]
    VOLEJNÍKOVÁ, J., V. BAJCIOVA, L. SULOVSKÁ, M. GEIEROVÁ, E. BURIANKOVA, M. JAROSOVA, M. HAJDÚCH, J. STERBA a V. MIHÁL. Bone marrow metastasis of malignant melanoma in childhood arising within a congenital melanocytic nevus. Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czech Republic. 2016, 160(3), 456-460. ISSN 1213-8118 . IF: 0.894. PMID: 27049531
  • [142]
    GILLILAND, C.T., D. ZUK, P. KOCIS, M. JOHNSON, S. HAY, M. HAJDÚCH, F. BIETRIX, G. AVERSA, C.P. AUSTIN a A.E. USSI. Putting translational science on to a global stage. Nature Reviews Drug Discovery. 2016, 15, 217-219. ISSN 1474-1776. IF: 57.000. PMID: 27032820
  • [141]
    HRUBY, M., K. AGRAWAL, O. POLICIANOVA, J. BRUS, J. SKOPAL, P. SVEC, M. OTMAR, P. DŽUBÁK, P. STEPANEK a M. HAJDÚCH. Biodegradable system for drug delivery of hydrolytically labile azanucleoside drugs. Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czech Republic. 2016, 160(2), 222-230. ISSN 1213-8118 . IF: 0.894. PMID: 27003313
  • [140]
    KALITA, O., R. TROJANEC, M. HOUDOVÁ MEGOVÁ , M. HAJDÚCH, M. VAVERKA, L. HRABALEK, M. ZLEVOROVA, J. DRÁBEK, L. TUČKOVÁ a J. VRBKOVÁ. Glioblastoma multiforme in patients with history of extracranial cancer: Case series. Clinical Neurology and Neurosurgery. 2016, 144(-), 39-43. ISSN 0303-8467. IF: 1.381. PMID: 26971293
  • [139]
    SCHADICH, E., J. HLAVÁČ, T. VOLNÁ, L. VARANASI, M. HAJDÚCH a P. DŽUBÁK. Effects of Ginger Phenylpropanoids and Quercetin on Nrf2-ARE Pathway in Human BJ Fibroblasts and HaCaT Keratinocytes. BioMed Research International . 2016, 2016, 2016:2173275. ISSN 2314-6133. IF: 2.476. PMID: 26942188
  • [138]
    VOLEJNÍKOVÁ, J., M. JAROSOVA, D. POSPÍŠILOVÁ, Z. NOVÁK, J. VRBKOVÁ, M. HAJDÚCH a V. MIHÁL. Treatment and prognosis of childhood acute lymphoblastic leukemia on protocols ALL-BFM 90, 95 and ALL IC-BFM 2002: a retrospective single-center study from Olomouc, Czech Republic. Neoplasma. 2016, 63(3), 456-61. ISSN 0028-2685. IF: 1.871. PMID: 26925793
  • [137]
    KOUDELÁKOVÁ, V., R. TROJANEC, J. VRBKOVÁ, S. DONEVSKA, K. BOUCHALOVÁ, M. KOLÁŘ, L. VARANASI a M. HAJDÚCH. Frequency of chromosome 17 polysomy in relation to CEP17 copy number in a large breast cancer cohort. Genes Chromosomes & Cancer. 2016, 55(5), 409-17. ISSN 1045-2257 . IF: 3.696. PMID: 26847577
  • [136]
    PERLÍKOVÁ, P., G. RYLOVÁ, P. NAUŠ, T. ELBERT, E. TLOUŠŤOVÁ, A. BOURDERIOUX, L. SLAVĚTÍNSKÁ, K. MOTYKA, D. DOLEŽAL, P. ZNOJEK, A. NOVÁ, M. HARVANOVÁ, P. DŽUBÁK, M. ŠILLER, J. HLAVÁČ, M. HAJDÚCH a M. HOCEK. 7-(2-Thienyl)-7-deazaadenosine (AB61), a new potent nucleoside cytostatic with a complex mode of action. Molecular Cancer Therapeutics. 2016, 15(5), 922-937. ISSN 1535-7163 . IF: 5.764. PMID: 26819331
  • [135]
    HEZOVA, R., A. KOVARIKOVA, J. SROVNAL, M. ZEMANOVÁ, T. HARUSTIAK, J. EHRMANN, M. HAJDÚCH, M. SACHLOVA, M. SVOBODA a O. SLABÝ. MiR-205 functions as a tumor suppressor in adenocarcinoma and an oncogene in squamous cell carcinoma of esophagus. Tumor Biology. 2015, 37(6), 8007-18. ISSN 1010-4283 . IF: 2.926. PMID: 26711784
  • [134]
    SULOVSKÁ, L., D. HOLUB, Z. ŽIDOVÁ, M. DIVOKÁ, M. HAJDÚCH, V. MIHÁL, J. VRBKOVÁ, M. HORVÁTHOVÁ a D. POSPÍŠILOVÁ. Characterization of iron metabolism and erythropoiesis in erythrocyte membrane defects and thalassemia traits. Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czech Republic. 2015, 160(2), 231-237. ISSN 1213-8118 . IF: 0.924. PMID: 26592557
  • [133]
    NAUŠ, P., O. CALETKOVÁ, P. PERLÍKOVÁ, L. SLAVĚTÍNSKÁ, E. TLOUŠŤOVÁ, J. HODEK, J. WEBER, P. DŽUBÁK, M. HAJDÚCH a M. HOCEK. Synthesis and biological profiling of 6-or 7-(het)aryl-7-deazapurine 4 '-C-methylribonucleosides. Bioorganic and Medicinal Chemistry. 2015, 23(23), 7422-7438. ISSN 0968-0896 . IF: 2.923. PMID: 26558518
  • [132]
    BRAUER, R., J. TURECKOVA, I. KANCHEV, M. KHOYLOU, J. ŠKARDA, J. PROCHAZKA, F. SPOUTIL, I.M. BECK, O. ŽBODÁKOVÁ, P. KASPAREK, V. KORINEK, K. CHALUPSKÝ, T. KARHU, K.H. HERZIG, M. HAJDÚCH, M. GREGOR a R. SEDLÁČEK. MMP-19 deficiency causes aggravation of colitis due to defects in innate immune cell function. Mucosal Immunology. 2016, 9(4), 974-985. ISSN 1933-0219. IF: 7.478. PMID: 26555704
  • [131]
    SOURAL, M., J. HODOŇ, N.J. DICKINSON, V. ŠIDOVÁ, S. GURSKÁ, P. DŽUBÁK, M. HAJDÚCH, J. ŠAREK a M. URBAN. Preparation of Conjugates of Cytotoxic Lupane Triterpenes with Biotin. Bioconjugate Chemistry. 2015, 26(12), 2563-70. ISSN 1043-1802. IF: 4.818. PMID: 26537839
  • [130]
    POL, J., H. FALTYSKOVA, L. KRASNY, M. VOLNY, O. VLACIL, M. HAJDÚCH, K. LEMR a V. HAVLICEK. Age-related changes in the lateral lipid distribution in a human lens described by mass spectrometry imaging. European Journal of Mass Spectrometry . 2015, 21(3), 297-303. ISSN 1469-0667. IF: 1.011. PMID: 26307709
  • [129]
    SURINOVA, S., M. CHOI, S. TAO, P.J. SCHÜFFLER, C.Y.. CHANG, T. CLOUGH, K. VYSLOUŽIL, M. KHOYLOU, J. SROVNAL, Y. LIU, M. MATONDO, R. HÜTTENHAIN, H. WEISSER, J.M. BUHMANN, M. HAJDÚCH, H. BRENNER, O. VITEK a R. AEBERSOLD. Prediction of colorectal cancer diagnosis based on circulating plasma proteins. EMBO Molecular Medicine. 2015, 7(9), 1166-1178. ISSN 1757-4676 . IF: 9.547. PMID: 26253081
  • [128]
    SURINOVA, S., L. RADOVÁ, M. CHOI, J. SROVNAL, H. BRENNER, O. VITEK, M. HAJDÚCH a R. AEBERSOLD. Non-invasive prognostic protein biomarker signatures associated with colorectal cancer. EMBO Molecular Medicine. 2015, 7(9), 1153-1165. ISSN 1757-4676. IF: 9.547. PMID: 26253080
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    GUCKÝ, T., I. FRYŠOVÁ, J. SLOUKA, M. HAJDÚCH a P. DŽUBÁK. Cyclocondensation reaction of heterocyclic carbonyl compounds, Part XIII: Synthesis and cytotoxic activity of some 3,7-diaryl-5-(3,4,5-trimethoxyphenyl)pyrazolo[4,3-e][1,2,4]triazines. European Journal of Medicinal Chemistry. 2009, 44(2), 891-900. ISSN 0223-5234. IF: 2.882.
  • [7]
    STÝSKALA, J., L. STÝSKALOVÁ, J. SLOUKA a M. HAJDÚCH. Synthesis of 2-aryl-4-(benzimidazol-2-yl)-1,2-dihydro[1,2,4]triazino-[4,5-a]benzimidazol-1-one derivatives with preferential cytotoxicity against carcinoma cell lines. European Journal of Medicinal Chemistry. 2008, 84(2), 449-455. ISSN 0223-5234. IF: 2.301.
  • [6]
    URBAN, M., J. KLINOT, I. TIŠLEROVÁ, D. BIEDERMANN, M. HAJDÚCH a I. CISAROVA. Reactions of activated lupane oxo-compounds with diazomethane: An approach to new derivatives of cytotoxic triterpenes. Synthesis-Stuttgart. 2006, 23(-), 3979-3986. ISSN 0039-7881. IF: 2.401.
  • [5]
    BIEDERMANN, D., J. ŠAREK, J. KLINOT, M. HAJDÚCH a P. DŽUBÁK. Fluorination of betulinines and other triterpenoids with DAST. Synthesis-Stuttgart. 2005, -(7), 1157-1163. ISSN 0039-7881. IF: 2.203.
  • [4]
    MIHÁL, V., M. HAJDÚCH, V. NOSKOVA, A. JANOŠŤÁKOVÁ, M. SAFAROVA, M. OREL, G. KUZMINA, B.. BLAZEK a D. POSPÍŠILOVÁ. The analysis od correlations between drug resistance and clinical/laboratory measures found in a group of children with all treated by ALL-BFM 90 protocol. Bulletin du Cancer. 2004, 91(4), -. ISSN 0007-4551. IF: 0.654.
  • [3]
    SELIGSON, A.L., J.W. CAMPION, R.C. TERRY, R. KUCEROVA, M. BIENOVA, M. HAJDÚCH a M. SOVÁK. Development of Fluridil, a topical suppressor of the androgen receptor in androgentic alopecia. Drug Development Research. 2003, 59(3), 292-306. ISSN 0272-4391. IF: 1.325.
  • [2]
    TRAVNICEK, Z., M. MALOŇ, M. BILER, M. HAJDÚCH, P. BROŽ, K. DOLEZAL, J. HOLUB, V. KRYŠTOF a M. STRNAD. Synthesis, characterization and biological activity of two nickel(II) complexes with 6-(2-chlorobenzylamino)purine. Transition Metal Chemistry. 2000, 25(3), 265-269. ISSN 0340-4285. IF: 0.825.
  • [1]
    BORKOVÁ, L., R. ADÁMEK, P. KALINA, P. DRAŠAR, P. DŽUBÁK, S. GURSKÁ, J. ŘEHULKA, M. HAJDÚCH, M. URBAN a J. ŠAREK. Synthesis and Cytotoxic Activity of Triterpenoid Thiazoles Derived from Allobetulin, Methyl Betulonate, Methyl Oleanonate, and Oleanonic Acid. ChemMedChem. 2017, 12(5), 390-398. ISSN 1860-7179. IF: 3.225.

Publications (Other Reviewed Journals):

  • [20]
    BÉBAROVÁ, L., P. SKALICKÝ, J. SROVNAL, A. PROKOPOVÁ, J. ZAPLETALOVA, M. HAJDÚCH a M. LOVECEK. The effect of circulating tumor cells on the survival of patients with pancreatic cancer − 5-year results. Rozhledy v chirurgii. 2018, 97(2), 94-98. ISSN 0035-9351.
  • [19]
    HOUDOVÁ MEGOVÁ , M., J. DRÁBEK, Z. DWIGHT, R. TROJANEC, V. KOUDELÁKOVÁ, J. VRBKOVÁ, O. KALITA, S. MLČOCHOVÁ, M. RABČANOVÁ a M. HAJDÚCH. Isocitrate Dehydrogenase Mutations are Better Prognostic Marker than O6-methylguanine-DNA Methyltransferase Promoter Methylation in Glioblastomas - a Retrospective, Single-centre Molecular Genetics Study of Gliomas. Klinická onkologie. 2017, 30(5), 361-371. ISSN 0862-495X.
  • [18]
    KUFOVA, Z., T. SEVCIKOVA, K. GROWKOVA, P. VOJTA, J. FILIPOVA, Z. ADAM, L. POUR, M. PENKA, R. RYSAVA, P. NEMEC, L. BROZOVA, P. VYCHYTILOVA, A. JURCZYSZYN, S. GROSICKI, A. BARCHNICKA, M. HAJDÚCH, M. SIMICEK a R. HAJEK. Biomarkers in Immunoglobulin Light Chain Amyloidosis. Klinická Onkologie. 2017, 30(2), 75-80. ISSN 0862-495X. PMID: 28 903 574
  • [17]
    ZATOPKOVA, M., J. FILIPOVA, T. JELINEK, P. VOJTA, T. SEVCIKOVA, M. SIMICEK, L. RIHOVA, R. BEZDEKOVA, K. GROWKOVA, Z. KUFOVA, J. SMEJKALOVA, M. HAJDÚCH, L. POUR, J. MINARIK, A. JUNGOVA, V. MAISNAR, F. KRYUKOV a R. HAJEK. Whole Exome Sequencing of Aberrant Plasma Cells in a Patient with Multiple Myeloma Minimal Residual Disease. Klinická Onkologie. 2017, 30(2), 75-80. ISSN 0862-495X. PMID: 28 903 574
  • [16]
    HOLUB, D., J. HOUDA, M. HAJDÚCH, D. POSPÍŠILOVÁ a P. DŽUBÁK. Stanovení hladiny hepcidinu-25 v séru pomocí SPE_LC_MS/MS metody. Chemagazín. 2016, 5, 8-10. ISSN 1210-7409.
  • [15]
    OŽDIAN, T., D. HOLUB, G. RYLOVÁ, J. VÁCLAVKOVÁ, M. HAJDÚCH a P. DŽUBÁK. Porovnání hmotnostně spektrometrických přístupů v proteomickém profilování léčiv. Chemagazín. 2016, 5, 8-11. ISSN 1210-7409.
  • [14]
    KOLECKOVA, M., G. KOŘÍNKOVÁ, V. KOUDELÁKOVÁ, J. POTOČKOVÁ, B. ŠOPÍKOVÁ, M. HAJDÚCH a Z. KOLÁŘ. Metoda RNAscope pro analýzu exprese HER2 ve vzorcích karcinomů mléčné žlázy s neprokázanou amplifikací. Onkologie. 2015, 9(5), 245-247. ISSN 1802-4475 .
  • [13]
    KULTAN, J., V. KOLEK, L. FAJKOSOVA, M. HAJDÚCH, J. DRÁBEK, T. TICHÝ a R. TACHEZY. Recurrent respiratory papillomatosis successfully treated with gefitinib: a case study. American Journal of Medical Case Reports. 2015, 3(11), 352-358. ISSN 2374-2151.
  • [12]
    ONDRYÁŠOVÁ, H., V. KOUDELÁKOVÁ, J. DRÁBEK, P. VANEK, R. SLAVKOVSKÝ a M. HAJDÚCH. Utilization of self-sampling kits for HPV testing in cervical cancer screening - pilot study. Česká gynekologie. 2015, 80(6), 436-443. ISSN 1210-7832.
  • [11]
    KONEČNÝ, P., S. GURSKÁ, P. ZNOJEK, E. SCHADICH, M. HAJDÚCH a P. DŽUBÁK. Reprofilování jako úspěšná strategie hledání nových léčiv. Farmakologická léčba. 2015, 4(10/2015), 12-18. ISSN 1805-398X.
  • [10]
    GHOTHIM, M., J. SROVNAL, L. BÉBAROVÁ, J. TESAŘÍKOVÁ, P. SKALICKÝ, D. KLOS, A. PROKOPOVÁ, M. VAHALÍKOVÁ, H. SLAVÍK, J. VRBKOVÁ, C. NEORAL, R. HAVLÍK, M. HAJDÚCH a M. LOVEČEK. Determination of CEA, EGFR and hTERT expression in peritoneal lavage in patients with pancreatic adenocarcinoma using RT - PCR method. Rozhledy v chirurgii. 2015, 94(11), 464-9. ISSN 0035-9351 . PMID: 26 766 154
  • [9]
    SPENEROVA, M., J. SROVNAL, J. POTĚŠIL, M. HAJDÚCH, V. MIHÁL a P. DŽUBÁK. Historie glukokortikoidní terapie v léčbě akutních leukémií u dětí. Česko-slovenská pediatrie. 2014, 69(6), 350-362. ISSN 0069-2328.
  • [8]
    HOUDA, J., P. DŽUBÁK, E. KARASKOVA, D. HOLUB, D. VYDRA, D. MLCUCHOVA, M. HAJDÚCH, O. POZLER a D. POSPÍŠILOVÁ. Výskyt anemie a význam měření hladiny hepcidinu metodou ELISA u dětí s nespecifickými střevními záněty. Česko-slovenská pediatrie. 2014, 69(3), 137-147. ISSN 0069-2328.
  • [7]
    ONDRYÁŠOVÁ, H., V. KOUDELÁKOVÁ a M. HAJDÚCH. Karcinom cervixu-možnosti detekce lidského papilomaviru. Česká gynekologie. 2013, 78(3), 289-294. ISSN 1210-7832.
  • [6]
    POSPÍŠILOVÁ, D., J. HOUDA, D. HOLUB, B. LUDÍKOVÁ, R. MOJZIKOVA, P. POSPISILOVA, Z. ŽIDOVÁ, K. KAPRALOVA, M. HORVÁTHOVÁ, M. HAJDÚCH a P. DŽUBÁK. Význam stanovení hladiny hepcidinu v diagnostice vybraných typů anémií v dětském věku. Transfuze a hematologie dnes. 2012, 18(-), 58-65. ISSN 1213-5763.
  • [5]
    NEUWIRTHOVA, J., P. SMILEK, J. JARKOVSKÝ, L. DUŠEK, J. ROTTENBERG, R. KOSTŘICA, J. SROVNAL, M. HAJDÚCH, J. DRÁBEK, J. KLOZAR a R. CERVENA. Sledování mutace KRAS při léčbě cetuximabem u spinocelulárních karcinomů hlavy a krku. Remedia. 2012, 22(3), 231-234. ISSN 0862-8947.
  • [4]
    KOUDELÁKOVÁ, V., M. KNEBLOVÁ a M. HAJDÚCH. Personalizovaná medicína a biomarkery v onkologii. Klinická farmakologie a farmacie. 2012, 26(4), 181-185. ISSN 1212-7973.
  • [3]
    BENEDÍKOVÁ, A., J. SROVNAL, M. SZKORUPA, P. SKALICKÝ, J. CHUDÁČEK, T. BOHANES, J. ŠKARDA, Z. KOLÁŘ, M. HAJDÚCH a J. KLEIN. Biomarkery detekce minimální systémové diseminace u nemocných s karcinomem plic. Rozhledy v chirurgii. 2012, 91(4), 209-215. ISSN 0035-9531.
  • [2]
    DUBSKA, L., M. VYSKOCILOVA, R. NENUTIL, D. VALIK, D. KNOFLICKOVA, P. FABIAN, I. KOCAKOVA, R. DEMLOVA, M. BERANEK, M. DRASTIKOVA, H. VOSMIKOVA, A. BODAY, K.. HORKA, J. SIMOVA, J. DRÁBEK, J. EHRMANN, M. HAJDÚCH, M. MATEJCKOVA, R. SIMA, D. TVRDIK, C. POVYSIL a A. RYSKA. Vyšetření mutačního statutu genu KRAS jako součást algoritmu léčby metastatického kolorektálního karcinomu. Časopis lékařů českých. 2011, 150(6), 321-326. ISSN 0008-7335.
  • [1]
    HRABALEK, L., O. KALITA, H. ŠTUDENTOVÁ, J. JANKOVA, J. EHRMANN, R. TROJANEC a M. HAJDÚCH. Intramedullary spinal cord and cauda equina metastasis of breast carcinoma: case report. Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czech Republic. 2010, 154, 1-3. ISSN 1213-8118.

Book Chapters:

  • [5]
    DŽUBÁK, P., M. URBAN a M. HAJDÚCH. Vývoj nových léčiv. In: Molekulární medicína. 1. vyd. Praha: Galén, 2015. Kapitola 11, s. 469-472. ISBN: 978-80-7492-121-6.
  • [4]
    ŠÁNA, J., M. HAJDÚCH a O. SLABÝ. MicroRNA and Glial tumors: Tiny Relation with Great Potential. In: Novel Therapeutics Concepts in Targeting Glioma. 1. vyd. Rijeka: InTech, 2012. Kapitola 4, s. 59-74. ISBN: 979-953-307-198-4.
  • [3]
    HAJDÚCH, M., J. DRÁBEK a R. TROJANEC. Význam biomarkerů pro indikaci cílené biologické léčby v onkologii. In: Biologická léčiva: Teoretické základy a klinická praxe. 1. vyd. Praha: Grada Publishing, 2012. Kapitola 2.8, s. 137-149. ISBN: 978-80-247-3727-0.
  • [2]
    HAJDÚCH, M. a R. PYTLÍK. Biologická léčba v onkologii. In: Biologická léčiva: Teoretické základy a klinická praxe. 1. vyd. Praha: Grada Publishing, 2012. Kapitola 2.7, s. 111-137. ISBN: 978-80-247-3727-0.
  • [1]
    ŠAREK, J., M. KVASNICA, M. VLK, M. URBAN, P. DŽUBÁK a M. HAJDÚCH. The Potential of Triterpenoids in the Treatment of Melanoma. In: Research on Melanoma – A Glimpse into Current Directions and Future Trends. 1.vyd. Rijeka: InTech, 2011. Kapitola 7, s. 125-158. ISBN: 978-953-307-293-7.

Books:


Patents, Utility models & other IP's :

[25] SUBSTITUTED HETEROPENTADIENO-PYRROLOPYRIMIDINE RIBONUCLEOSIDES FOR THERAPEUTIC USE, PV 2016-465

Patent: CZ 307 334. Granted: 2. 5. 2018. Ownership: Palacky University, Olomouc. Inventors: Hocek Michal, Tokarenko Anna, Smoleń Sabina, Džubák Petr, Hajdúch Marián.

Status: Available.

[24] METHOD OF PREDICTING THE TUMOR RESPONSE TO DNA METHYLATION INHIBITORS AND ALTERNATIVE THERAPEUTIC REGIMENS FOR OVERCOMING RESISTANCE, EP 14161897.5
  1. Patent appl. EP 14161897.5 (ASH1L), Patent: EP 2924125, Granted: 17. 6. 2017, Ownership: Palacky University Olomouc, Inventors: Agrawal Khushboo, Frydrych Ivo, Džubák PetrHajdúch Marián
  2. Patent appl. EP 15717786.6 (BRD4), Patent: EP 3122902, Granted: 16. 5. 2018, Ownership: Palacký University, Olomouc, Inventors: Agrawal KhushbooFrydrych IvoDžubák PetrHajdúch Marián

​Status: Available 

[23] BENZOISOTHIAZOLE-1, 1-DIOXIDE-3-HYDRAZONES AND THEIR USE IN ANTICANCER THERAPY, PV 2014-322
  1. Patent: CZ 306 554, Granted: 25. 1. 2017, Ownership: Institute of Chemical technology Prague, Palacky University Olomouc, Institute of Molecular Genetics CAS, Inventors: Kaplánek Robert, Bříza Tomáš, Havlík Martin, Rak Jakub, Kejík Zdeněk, Džubák PetrHajdúch Marián, Konečný Petr, Štěpánková Jana, Králová Jarmila, Král Vladimír

​Status: Available 

[22] FLUORESCENT DERIVATIVE FOR NON-CATALYTIC LABELING OF NUCLEIC ACID AND PEPTIDE COMPONENTS, PUV 2016-32558
  1. Utility Model: CZ 30 136, Granted: 13. 12. 2016, Ownership: Palacky University, Olomouc, Inventors: Jedináková Petra, Hlaváč JanVáclavková Jana, Konečný Petr, Džubák Petr, Hajdúch Marián

Status: Available

[21] METHOD OF DETERMINATION OF CANCER CELL DRUG SENSITIVITY TOWARDS AURORA KINASE INHIBITORS AND OVERCOMIMG THEIR RESISTANCE, Priority Appl. EP 1192330.6
  1. Patent: EP 2788504, Granted: 21. 7. 2016, Ownership: Palacky University Olomouc, Institute of Animal Physiology and Genetics AS CR, Inventors: Kollaredy MadhuHajdúch MariánDžubák PetrSrovnal JosefHrabáková, Kovářová Hana  
  2. Patent: JP 6144696, Granted: 19. 5. 2017, Ownership: Palacky University Olomouc, Institute of Animal Physiology and Genetics AS CR, Inventors: Kollaredy Madhu, Hajdúch MariánDžubák PetrSrovnal Josef, Hrabáková, Kovářová Hana

Status: Available

[20] CARBONIC ANHYDRASE INHIBITORS AND METHOD OF THEIR PRODUCTION, Priority Appl. CZ PV 2011-676
  1. Patent: EP 2 771 015, Granted: 16. 3. 2016, Ownership: Institute of Organic Chemistry and Biochemistry AS CR, Institute of Molecular Genetics AS CR, Institute of Inorganic Chemistry AS CVR, Palacky University Olomouc, Inventors: Brynda Jiří, Cígler Petr, Gruner Bohumír, Maloy Řezáčová Pavlína, Mader Pavel, Šícha Václav, Bakardijev Mario, Džubák PetrHajdúch Marián
  2. Patent: US 9,290,529, Granted: 22. 3. 2016, Ownership: Institute of Organic Chemistry and Biochemistry AS CR, Institute of Molecular Genetics AS CR, Institute of Inorganic Chemistry AS CVR, Palacky University Olomouc, Inventors: Brynda Jiří, Cígler Petr, Gruner Bohumír, Maloy Řezáčová Pavlína, Mader Pavel, Šícha Václav, Bakardijev Mario, Džubák PetrHajdúch Marián

Status: Available

[19] CULTURE DISH, Priority Appl. CZ PUV 2015-31565, Priority Appl. CZ PVZ 2015-40394
  1. Utility Model: CZ 28 806, Granted: 10. 11. 2015, Ownership: Palacky University Olomouc, Inventors: Džubák PetrHajdúch Marián
  2. Design: CZ 36 622, Granted: 28. 12. 2015, Ownership: Palacky University Olomouc, Inventors: Džubák PetrHajdúch Marián
  3. Registered Community Design: RCD 003039577-0001, Granted: 23. 3. 2016, Ownership: Palacky University Olomouc, Inventors: Džubák PetrHajdúch Marián
  4. Registered Community Design: RCD 003039577-0002, Granted: 23. 3. 2016, Ownership: Palacky University Olomouc, Inventors: Džubák PetrHajdúch Marián

Status: Available 

[18] ASYMMETRIC TROGER BASES WITH HYDRAZONE GROUP AND THEIR USE IN THE TREATMENT OF ONCOLOGIC DISEASES, Priority Appl. CZ PV 2014-317
  1. Patent: CZ 305 683, Granted: 23. 12. 2015, Ownership: Institute of Chemical technology Prague, Palacky University Olomouc, Institute of molecular genetics AS CR, Inventors: Rak Jakub, Kaplánek Robert, Štulcová Tereza, Drašar Pavel, Havlík Martin, Bříza Tomáš, Džubák PetrHajdúch MariánKonečný PetrŠtěpánková Jana, Králová Jarmila, Král Vladimír

Status: Available  

[17] DIOXOCYCLOBUTENYL HYDRAZONES AND THEIR ANTICANCER ACTIVITY, Priority Appl. CZ PV 2014-321
  1. Patent: CZ 305 626, Granted: 2. 12. 2015, Ownership: Institute of Chemical technology Prague, Palacky University Olomouc, Institute of molecular genetics AS CR, Inventors: Havlík Martin, Kaplánek Robert, Dolenský Bohumil, Rak Jakub, Bříza Tomáš, Džubák PetrHajdúch MariánKonečný PetrŠtěpánková Jana, Králová Jarmila, Král Vladimír

Status: Available 

[16] CAFFEINE-8-HYDRAZONES AS NOVEL CYTOSTATICS FOR THE TREATMENT OF ONCOLOGIC DISEASES, Priority Appl. CZ PV 2014-307
  1. Patent: CZ 305 625, Granted: 2. 12. 2015, Ownership: Institute of Chemical technology Prague, Palacky University Olomouc, Institute of molecular genetics AS CR, Inventors: Rak Jakub, Kaplánek Robert, Štulcová Tereza, Drašar Pavel, Havlík Martin, Bříza Tomáš, Džubák PetrHajdúch MariánKonečný PetrŠtěpánková Jana, Králová Jarmila, Král Vladimír 

Status: Available 

[15] CHOLYL HYDRAZONES AND THEIR USE IN THE TREATMENT OF TUMOR AND LEUKEMIA DISEASES, Priority Appl. CZ PV 2014-305
  1. Patent: CZ 305 607, Granted: 25. 11. 2015, Ownership: Institute of Chemical technology Prague, Institute of molecular genetics AS CR, Palacky University OlomoucInventors: Rak Jakub, Kaplánek Robert, Štulcová Tereza, Drašar Pavel, Havlík Martin, Bříza Tomáš, Džubák PetrHajdúch MariánKonečný PetrŠtěpánková Jana, Králová Jarmila, Král Vladimír

Status: Available

[14] BENZOTHIAZOLE-SUBSTITUTED CYCLOBUT-3-ENE-1, 2-DIONE-3-HYDRAZONES AND THEIR USE IN THE TREATMENT OF VARIOUS TYPES OF LEUKEMIA AND TUMOUR DISEASES, Priority Appl. CZ PV 2014-306
  1. Patent: CZ 305 538, Granted: 14. 10. 2015, Ownership: Institute of Chemical Technology Prague, Palacky University Olomouc, Institute of Molecular Genetics AS CR, Inventors: Kaplánek Robert, Bříza Tomáš, Havlík Martin, Rak Jakub, Kejík Zdeněk, Krejčí Petr, Džubák PetrHajdúch MariánŠtěpánková JanaKonečný PetrKrálová Jarmila, Král Vladimír 

Status: Available

[13] SUBSTITUTED 7-DEZAPURIN RIBONUCLEOSIDES, Priority Appl. CZ PV 2013-845
  1. Patent: JP 5485172, Granted: 7. 5. 2014, Ownership: Institute of Organic Chemistry and Biochemistry AS CR, Palacky University Olomouc, Inventors: Hocek Michal, Nauš Petr, Caletková Olga, Džubák Petr, Hajdúch Marián
  2. Patent: CZ 305 466, Granted: 7. 9. 2015, Ownership: Institute of Organic Chemistry and Biochemistry AS CR, Palacky University Olomouc, Inventors: Hocek Michal, Nauš Petr, Caletková Olga, Džubák PetrHajdúch Marián 
  3. Patent: AU 20142777740, Granted: 25. 2. 2016, Ownership: Institute of Organic Chemistry and Biochemistry AS CR, Palacky University Olomouc, Inventors: Hocek Michal, Nauš Petr, Caletková Olga, Džubák PetrHajdúch Marián 
  4. Patent: US 9,586,986, Granted: 7. 3. 2017, Ownership: Institute of Organic Chemistry and Biochemistry AS CR, Palacky University Olomouc, Inventors: Hocek Michal, Nauš Petr, Caletková Olga, Džubák PetrHajdúch Mariá

Status: Available

 

[12] KIT FOR INVESTIGATING HER2 GENE STATUS IN SAMPLES OF BREAST CANCER SAMPLES USING QUANTITATIVE PCR METHOD, Priority Appl. CZ PUV 2015-30957
  1. Utility Model: CZ 28 596, Granted: 7. 9. 2015, Ownership: Palacky University Olomouc, Inventors: Koudeláková Vladimíra, Berkovcová Jitka, Trojanec Radek, Hajdúch Marián

Status: Excl. Licensed

[11] METHOD OF DETERMINING SENSITIVITY OF PATIENTS WITH TUMOROUS DISEASE TO TREATMENT WITH HER-2 RECEPTOR INHIBITORS, Priority Appl. CZ PV 2008-40
  1. Patent: CZ 302 709, Granted: 3. 8. 2011, Ownership: Palacky University Olomouc, Masaryk Memorial Cancer Institute Brno, Inventors: Hajdúch MariánDziechcarková Marta, Radová Lenka, Svoboda Marek
  2. Patent: US 8,465,936, Granted: 18. 6. 2013, Ownership: Palacky University Olomouc, Masaryk Memorial Cancer Institute Brno, Inventors: Hajdúch MariánDziechcarková Marta, Radová Lenka, Svoboda Marek
  3. Patent: JP 5295268, Granted: 18. 12. 2013, Ownership: Palacky University Olomouc, Masaryk Memorial Cancer Institute Brno, Inventors: Hajdúch MariánDziechcarková Marta, Radová Lenka, Svoboda Marek
  4. Patent: EP 2 241 890, Granted: 9. 4. 2014, Ownership: Palacky University Olomouc, Masaryk Memorial Cancer Institute Brno, Inventors: Hajdúch MariánDziechcarková Marta, Radová Lenka, Svoboda Marek

Status: Available

[10] TRITERPENOID DERIVATES I, Priority Appl. GB 0012528.6, GB 0012823.1
  1. Patent: US 7,858,606, Granted: 28. 12. 2010, Co-ownership: Charles University Prague, Palacky University Olomouc, Inventors: Šarek JanHajdúch Marián

Status: Available

[9] PEPTIDE, PROCESS FOR ITS PREPARATION AND USE, Priority Appl. CZ PV 2009-646
  1. Patent: CZ 301 822, Granted: 24. 5. 2010, Ownership: Institute of Organic Chemistry and Biochemistry AS CR, Veterinary Research Institute, Palacky University Olomouc, Inventors: Čeřovský Václav, Voburka Zdeněk, Fučík Vladimír, Bednárová Lucie, Kolář MilanHajdúch Marián, Slaninová Jiřina, Hovorka Oldřich, Cvačka Josef, Turánek Jaroslav

Status: Available

[8] TRITERPENOID 2-DEOXY GLYCOSIDES, METHOD OF PREPARATION THEREOF AND USE THEREOF AS MEDICAMENTS, Priority Appl. CZ PV 2008-723
  1. Patent: CZ 301 318, Granted: 2. 12. 2009, Ownership: Palacky University Olomouc, Inventors: Šarek Jan, Spáčilová Pavla, Hajdúch Marián
  2. Patent: US 8,680,251, Granted: 25. 3. 2014, Ownership: Palacky University Olomouc, Inventors: Šarek Jan, Spáčilová Pavla, Hajdúch Marián
  3. Patent: JP 5566392, Granted: 6. 8. 2014, Ownership: Palacky University Olomouc, Inventors: Šarek Jan, Spáčilová Pavla, Hajdúch Marián
  4. Patent: CA 2 741 096, Granted: 20. 1. 2015, Ownership: Palacky University Olomouc, Inventors: Šarek Jan, Spáčilová Pavla, Hajdúch Marián

Status: Available

[7] TRITERPENOID DERIVATIVES FOR TREATING TUMOR DISEASES AND PHARMACEUTICAL COMPOSITION IN WHICH THE DERIVATIVES ARE COMPRISED, Priority Appl. CZ PV 2008-528
  1. Patent: CZ 301 158, Granted: 12. 10. 2009, Ownership: Charles University Prague, Palacky University Olomouc, Inventors: Šarek Jan, Biedermann David, Hajdúch Marián

Status: Available

[6] METHOD OF DETERMINING SENSITIVITY OF PATIENTS WITH TUMOROUS DISEASE TO TREATMENT WITH HER-2 RECEPTOR INHIBITORS, Priority Appl. CZ PV 2008-40
  1. Patent: CZ 302 709, Granted: 3. 8. 2011, Ownership: Palacky University Olomouc, Masaryk Memorial Cancer Institute Brno, Inventors: Hajdúch Marián, Dziechcarková Marta, Radová Lenka, Svoboda Marek
  2. Patent: US 8,465,936, Granted: 18. 6. 2013, Ownership: Palacky University Olomouc, Masaryk Memorial Cancer Institute Brno, Inventors: Hajdúch Marián, Dziechcarková Marta, Radová Lenka, Svoboda Marek
  3. Patent: JP 5295268, Granted: 18. 12. 2013, Ownership: Palacky University Olomouc, Masaryk Memorial Cancer Institute Brno, Inventors: Hajdúch Marián, Dziechcarková Marta, Radová Lenka, Svoboda Marek
  4. Patent: EP 2 241 890, Granted: 9. 4. 2014, Ownership: Palacky University Olomouc, Masaryk Memorial Cancer Institute Brno, Inventors: Hajdúch Marián, Dziechcarková Marta, Radová Lenka, Svoboda Marek

Status: Available

[5] METHOD OF PREPARATION AND ISOLATION OF BETULIN DIACETATE FROM BIRCH BARK FROM PAPER MILLS AND ITS OPTIONAL PROCESSING TO BETULIN, Priority Appl. CZ PV 2007-36
  1. Patent: CZ 301 038, Granted: 9. 9. 2009, Ownership: Charles University Prague, Palacky University Olomouc, I.Q.A., Inventors: Šarek Jan, Svoboda Michal, Hajdúch Marián
  2. Patent: CA 2 673 226, Granted: 8. 1. 2013, Ownership: Charles University Prague, Palacky University Olomouc, I.Q.A., Inventors: Šarek Jan, Svoboda Michal, Hajdúch Marián
  3. Patent: US 8, 093, 413, Granted: 10. 1. 2012, Ownership: Charles University Prague, Palacky University Olomouc, I.Q.A., Inventors: Šarek Jan, Svoboda Michal, Hajdúch Marián
  4. Patent: EP 2 125 860, Granted: 19. 12. 2012, Ownership: Charles University Prague, Palacky University Olomouc, I.Q.A., Inventors: Šarek Jan, Svoboda Michal, Hajdúch Marián

Status: Available

[4] PROCESS FOR PREPARING INCLUSION COMPLEX OF PENTACYCLIC AND TETRACYCLIC TERPENOIDS, PROCESS FOR PREPARING PHARMACEUTICAL COMPOSITION CONTAINING THIS INCLUSION COMPLEX, INCLUSION COMPLEX OF PENTACYCLIC OR TETRACYCLIC TERPENOID AND PHARMACEUTICAL COMPOSITION, Priority Appl. CZ PV 2006-606
  1. Patent: CZ 300 722, Granted: 13. 5. 2009, Ownership: Charles University Prague, Palacky University Olomouc, I.Q.A., Inventors: Šarek Jan, Hajdúch Marián, Svoboda Michal, Nováková Kateřina
  2. Patent: US 8,653,056, Granted: 18. 2. 2014, Ownership: Charles University Prague, Palacky University Olomouc, I.Q.A., Inventors: Šarek Jan, Hajdúch Marián, Svoboda Michal, Nováková Kateřina, Spáčilová Pavla, Kubelka Tomáš, Biedermann David
  3. Patent: CA 2 666 437, Granted: 24. 4. 2012, Ownership: Charles University Prague, Palacky University Olomouc, I.Q.A., Inventors: Šarek Jan, Hajdúch Marián, Svoboda Michal, Nováková Kateřina, Spáčilová Pavla, Kubelka Tomáš, Biedermann David
  4. Patent: CA 2 762 911, Granted: 5. 11. 2013, Ownership: Charles University Prague, Palacky University Olomouc, I.Q.A., Inventors: Šarek Jan, Hajdúch Marián, Svoboda Michal, Nováková Kateřina, Spáčilová Pavla, Kubelka Tomáš, Biedermann David
  5. Patent: EP 2068882, Granted: 23. 08. 2017, Ownership: Charles University Prague, Palacky University Olomouc, I.Q.A., Inventors: Šarek JanHajdúch Marián, Svoboda Michal, Nováková Kateřina, Spáčilová Pavla, Kubelka Tomáš, Biedermann David

Status: Available

[3] DERIVATES OF 2-PHENYL-3-HYDROXYQUINOLINE-4(1H)-ONE AND METHODS OF THEIR PREPARATION AND UTILIZATION, Priority Appl. CZ PV 2006-546
  1. Patent: CZ 300 589, Granted: 13. 5. 2009, Ownership: Palacky University Olomouc, Inventors: Krejčí Petr, Hlaváč Jan, Hradil Pavel, Hajdúch Marián
  2. Patent: US 8,299,092, Granted: 30. 10. 2012, Ownership: Palacky University Olomouc, Inventors: Krejčí Petr, Hlaváč Jan, Hradil Pavel, Hajdúch Marián
  3. Patent: EP 2 064 200, Granted: 4. 9. 2013, Ownership: Palacky University Olomouc, Inventors: Krejčí Petr, Hlaváč Jan, Hradil Pavel, Hajdúch Marián

Status: Terminated

[2] TRITERPENOID DERIVATES III, Priority Appl. GB 0012526.0
  1. Patent: US 7,041,701, Granted: 9. 5. 2006, Co-ownership: Charles University Prague, Palacky University Olomouc, Inventors: Šarek Jan, Hajdúch Marián
  2. Patent: EP 1 294 370, Granted: 5. 10. 2005, Co-ownership: Charles University Prague, Palacky University Olomouc, Inventors: Šarek Jan, Hajdúch Marián

Status: Available

[1] TRITERPENOID DERIVATES II, Priority Appl. GB 0012532.8, GB 0012825.6
  1. Patent: EP 1289977, Granted: 23. 3. 2005, Co-ownership: Charles University Prague, Palacky University Olomouc, Inventors: Šarek JanHajdúch Marián

Status: Terminated


Doctoral students mentor:

[8] Martin Ondra, Role of ribosomal proteins and ribosomal stress in case of DNA damage,
Ph.D. specialization: , status: Ongoing, from: 2017
[7] Agáta Kubíčková, Cell models for optical screening of biologically active compounds,
Ph.D. specialization: Oncology, status: Ongoing, from: 2016
[6] Natálie Táborská, High throughput sequencing methods in biomarker identification and validation ,
Ph.D. specialization: , status: Ongoing, from: 2014
[5] Zuzana Macečková, Molecular pathology of Diamond-Blackfan anemia,
Ph.D. specialization: , status: Ongoing, from: 2014
[4] Magdalena Uvírová, Molecular genetic studies of selected solid tumors,
Ph.D. specialization: Pediatrics, status: Graduated, from: 2011 to 2016
[3] Khushboo Agrawal, 5-Azacytidine Nucleosides and their Derivatives: Molecular Hallmarks of Drug Resistance & Alternative Therapeutic Regimen,
Ph.D. specialization: , status: Graduated, from: 2010 to 2017
[2] Petr Vojta, Molecular biological methods of preimplantation diagnosis,
Ph.D. specialization: , status: Ongoing, from: 2009
[1] Andrea Prokopová, Detection and clinical importance of minimal residual disease in solid tumours,
Ph.D. specialization: , status: Ongoing, from: 2009