Frydrych Ivo Ph.D.

Frydrych Ivo Ph.D.'s picture
Phone: +420 585 632 145
Curriculum Vitae: download
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My research interests focus on development and validation of cellular gen reporters for high-throughput screening (HTS) of biologically active compounds. I´m working on a development of luminiscent technologies for mapping of cell signalling pathways activation/inhibition  as a powerful tool for assessing the biological impact of small molecule compounds. The another goal is development of cellular fluorescent  models for monitoring cell death hallmarks. My current research focuses on the investigation of pyrimidine derivatives as potential inhibitors of RAGE receptor, which is implicated in the regulation of diverse pathological conditions such as cancer, neurodegenerative diseases, diabetes or inflammation.


Publications (Impact Factor Journals):


Patents, Utility models & other IP's :

[1] METHOD OF PREDICTING THE TUMOR RESPONSE TO DNA METHYLATION INHIBITORS AND ALTERNATIVE THERAPEUTIC REGIMENS FOR OVERCOMING RESISTANCE, EP 14161897.5
  1. Patent appl. EP 14161897.5 (ASH1L), Patent: EP 2924125, Granted: 17. 6. 2017, Ownership: Palacky University Olomouc, Inventors: Agrawal Khushboo, Frydrych Ivo, Džubák PetrHajdúch Marián
  2. Patent appl. EP 15717786.6 (BRD4), Patent: EP 3122902, Granted: 16. 5. 2018, Ownership: Palacký University, Olomouc, Inventors: Agrawal KhushbooFrydrych IvoDžubák PetrHajdúch Marián

​Status: Available 



Master students mentor:

[1] Ivana Reiterová, Preparation of cell-based reporter assay for high-throughput screening of small molecules as potential receptor for advanced glycation endproducts inhibitors,
status: Ongoing, from: 2015