Dear colleagues,
I would like to invite you to the lecture by Lenka Slavíčková "The effect of zebularine on DNA methyltransferases in multiple myeloma cell lines". The lecture will be on Wednesday March 18th at 9AM in the room 1.09 at IMTM.
Abstract
Multiple myeloma is a malignant plasma cell disorder characterized by frequent epigenetic alterations, including DNA hypermethylation. DNA methyltransferases (DNMTs) are key enzymes in this process, and their inhibition represents a promising therapeutic approach. Among potential demethylating agents, zebularine has gained attention for its ability to modulate DNMT activity and affect gene expression.
This presentation focuses on the effects of zebularine on DNA methyltransferases in multiple myeloma cell lines KMS-12-BM, KMS-12-PE, and U266. Experimental results evaluating DNMT expression, and downstream epigenetic changes will be discussed, highlighting the potential of zebularine as a tool for epigenetic therapy in multiple myeloma.