Gurská Soňa Ph.D.

Gurská Soňa Ph.D.'s picture
Phone: +420 585632069
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I am working in the high throughput screening facility with focus on the testing of new chemical compounds, the implementation and validation of new biochemical and cell based assays into HTS. I am interested in identifying the active substances as potential drugs. I am experienced in liquid handling and robotic automation. Previously I was working in a field of mutagenesis and carcinogenesis at Cancer Reasearch Institute in Bratislava.


Publications (Impact Factor Journals):

  • [15]
    NOWIKOW, C., R. FUERST, M. KAUDERER, C. DANK, W. SCHMID, M. HAJDÚCH, J. ŘEHULKA, S. GURSKÁ, O. MOKSHYNA, P. POLISHCHUK, I. ZUPKO, P. DŽUBÁK a U. RINNER. Synthesis and biological evaluation of cis-restrained carbocyclic combretastatin A-4 analogs: Influence of the ring size and saturation on cytotoxic properties. Bioorganic & Medicinal Chemistry. 2019, -, -. ISSN 0968-0896. IF: 2.802. PMID: 31401010
  • [14]
    LOBAZ, V., R. KONEFAL, J. PANEK, M. VLK, J. KOZEMPEL, M. PETŘÍK, Z. NOVÝ, S. GURSKÁ, P. ZNOJEK, P. STEPANEK a M. HRUBY. In Situ In Vivo radiolabeling of polymer-coated hydroxyapatite nanoparticles to track their biodistribution in mice. Colloids and surfaces. B, Biointerfaces. 2019, 179, 143-152. ISSN 0927-7765. IF: 3.997. PMID: 30954015
  • [13]
    PORUBA, M., Z. RÁCOVÁ (MATUŠKOVÁ), M. HÜTTL, H. MALINSKA, O. OLIYARNYK, I. MARKOVA, S. GURSKÁ, L. KAZDOVA a R. VECERA. Fenofibrate Decreases Hepatic P-Glycoprotein in a Rat Model of Hereditary Hypertriglyceridemia. Frontiers in Pharmacology. 2019, 10, 56. ISSN 1663-9812. IF: 3.831. PMID: 30787874
  • [12]
    TOKARENKO, A., B. LIŠKOVÁ, S. SMOLEN, N. TÁBORSKÁ, M. TICHÝ, S. GURSKÁ, P. PERLÍKOVÁ, I. FRYDRYCH, E. TLOUŠŤOVÁ, P. ZNOJEK, H. MERTLIKOVA-KAISEROVA, L. POSTOVA SLAVETINSKA, R. POHL, B. KLEPETAROVA, N. KHALID, Y. WENREN, R. LAPOSA, P. DŽUBÁK, M. HAJDÚCH a M. HOCEK. Synthesis and Cytotoxic and Antiviral Profiling of Pyrrolo- and Furo-fused 7-Deazapurine Ribonucleosides. Journal of Medicinal Chemistry. 2018, 61(20), 9347-9359. ISSN 0022-2623. IF: 6.253. PMID: 30281308
  • [11]
    JURÁŠEK, M., M. CERNOHORSKA, J. ŘEHULKA, V. SPIWOK, T. SULIMENKO, E. DRABEROVA, M. DARMOSTUK, S. GURSKÁ, I. FRYDRYCH, R. BURIÁNOVÁ, T. RUML, M. HAJDÚCH, P. BARTŮNĚK, P. DRABER, P. DŽUBÁK, P. DRAŠAR a D. SEDLÁK. Estradiol Dimer Inhibits Tubulin Polymerization and Microtubule Dynamics. The Journal of Steroid Biochemistry and Molecular Biology. 2018, 183, 68-79. ISSN 0960-0760. IF: 4.561. PMID: 29803726
  • [10]
    POKORNÝ, J., S. KRAJČOVIČOVÁ, M. HAJDÚCH, M. HOLOUBEK, S. GURSKÁ, P. DŽUBÁK, T. VOLNÁ, I. POPA a M. URBAN. Triterpenic azines, a new class of compounds with selective cytotoxicity to leukemia cells CCRF-CEM. Future Medicinal Chemistry. 2018, 10(5), 483-491. ISSN 1756-8919. IF: 3.566. PMID: 29424548
  • [9]
    SESTAK, S., M. BELLA, T. KLUNDA, S. GURSKÁ, P. DŽUBÁK, F. WÖLS, I. WILSON, V. SLADEK, M. HAJDÚCH, M. POLÁKOVÁ a J. KONA. N-Benzyl Substitution of Polyhydroxypyrrolidines: The Way to Selective Inhibitors of Golgi α-Mannosidase II. ChemMedChem. 2018, 13(4), 373-383. ISSN 1860-7179. IF: 3.225. PMID: 29323461
  • [8]
    DAS, V., T. FÜRST, S. GURSKÁ, P. DŽUBÁK a M. HAJDÚCH. Evaporation-reducing Culture Condition Increases the Reproducibility of Multicellular Spheroid Formation in Microtiter Plates. Journal of Visualized Experiments. 2017, 121, doi: 10.3791/55403. ISSN 1940-087X. IF: 1.113. PMID: 28362402
  • [7]
    TICHÝ, M., S. SMOLEN, E. TLOUŠŤOVÁ, R. POHL, T. OŽDIAN, K. HEJTMÁNKOVÁ, B. LIŠKOVÁ, S. GURSKÁ, P. DŽUBÁK, M. HAJDÚCH a M. HOCEK. Synthesis and Cytostatic and Antiviral Profiling of Thieno-Fused 7-Deazapurine Ribonucleosides. Journal of Medicinal Chemistry. 2017, 60(6), 2411-2424. ISSN 0022-2623. IF: 5.589. PMID: 28221790
  • [6]
    BORKOVÁ, L., R. ADÁMEK, P. KALINA, P. DRAŠAR, P. DŽUBÁK, S. GURSKÁ, J. ŘEHULKA, M. HAJDÚCH, M. URBAN a J. ŠAREK. Synthesis and Cytotoxic Activity of Triterpenoid Thiazoles Derived from Allobetulin, Methyl Betulonate, Methyl Oleanonate, and Oleanonic Acid. ChemMedChem. 2017, 12(5), 390-398. ISSN 1860-7179 . IF: 2.980. PMID: 28084676
  • [5]
    JURÁŠEK, M., P. DŽUBÁK, S. RIMPELOVA, D. SEDLÁK, P. KONEČNÝ, I. FRYDRYCH, S. GURSKÁ, M. HAJDÚCH, K. BOGDANOVÁ, M. KOLÁŘ, T. MÜLLER, E. KMONICKOVA, T. RUML, J. HARMATHA a P. DRAŠAR. Trilobolide-steroid hybrids: Synthesis, cytotoxic and antimycobacterial activity. Steroids. 2017, 117(2017), 97-104. ISSN 0039-128X. IF: 2.513. PMID: 27543674
  • [4]
    BORKOVÁ, L., S. GURSKÁ, P. DŽUBÁK, R. BURIÁNOVÁ, M. HAJDÚCH, J. ŠAREK, I. POPA a M. URBAN. Lupane and 18α-oleanane derivatives substituted in the position 2, their cytotoxicity and influence on cancer cells. European Journal of Medicinal Chemistry. 2016, 121, 120-131. ISSN 0223-5234 . IF: 4.519. PMID: 27236068
  • [3]
    DAS, V., T. FÜRST, S. GURSKÁ, P. DŽUBÁK a M. HAJDÚCH. Reproducibility of Uniform Spheroid Formation in 384-Well Plates: The Effect of Medium Evaporation. Journal of Biomolecular Screening. 2016, 21(9), 923-30. ISSN 1087-0571 . IF: 2.444. PMID: 27226477
  • [2]
    SOURAL, M., J. HODOŇ, N.J. DICKINSON, V. ŠIDOVÁ, S. GURSKÁ, P. DŽUBÁK, M. HAJDÚCH, J. ŠAREK a M. URBAN. Preparation of Conjugates of Cytotoxic Lupane Triterpenes with Biotin. Bioconjugate Chemistry. 2015, 26(12), 2563-70. ISSN 1043-1802. IF: 4.818. PMID: 26537839
  • [1]
    FUNK, P., K. MOTYKA, P. DŽUBÁK, P. ZNOJEK, S. GURSKÁ, J. KUSZ, C. MCMASTER, M. HAJDÚCH a M. SOURAL. Preparation of 2-phenyl-3-hydroxyquinoline- 4(1H)-one-5-carboxamides as potential anticancer and fluorescence agents. RSC Advances. 2015, 5(60), 48861-48867. ISSN 2046-2069. IF: 3.289.

Publications (Other Reviewed Journals):



Master students mentor:

[2] Vojtěch Synek, Development of the assay for measurement of the CA activity and its implementation into HTS,
status: Ongoing, from: 2018
[1] Kristýna Dostálová, Cell-based assays for high-throughput screening in drug discovery,
status: Graduated, from: 2014 to 2016


Bachelor students mentor:

[1] Vojtěch Synek, Cytotoxicity tests for high-throughput drug discovery,
status: Graduated, from: 2014 to 2018