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Translational diseases models and neurodegeneration

Laboratory of Experimental Medicine
Junior research group

Our research delves into the intricate mechanisms underlying neurodegenerative disorders (NDDs), aiming to develop targeted therapeutic interventions. We embark on this journey by scrutinizing 'druggable' targets implicated in age-related protein misfolding and aggregation. Currently, our focus lies on pharmacological modulators targeting tau and synuclein spreading mechanisms in Alzheimer's and Parkinson's diseases. As we explore tau-targeting agents to attenuate tau spreading in tauopathies, we are also investigating the impact of tau mutations on the efficacy of these agents in targeted therapy.

Concurrently, we are actively engaged in developing selective inhibitors of Bruton’s tyrosine kinase (BTK) as potential therapeutic agents. Our specific interest lies in elucidating how BTK inhibition can ameliorate neuroinflammation and subsequent neuronal damage, with potential applications across various diseases, including cancer.

To achieve our research objectives, we utilize advanced methodologies encompassing peptides, microfluidic devices, tissue-on-a-chip models, genetically engineered cell lines, 3D cell cultures, and induced pluripotent stem cells. These models serve as faithful representations of the intricate pathology observed in NDDs, providing invaluable insights for the development of effective therapeutic strategies.

  • Drug discovery and repurposing 
  • Proteinopathies
  • Prion-like spreading of protein in neurodegeneration 
  • Three-dimensional cell culture systems 
  • Human iPSC-based disease modelling and drug discovery 
  1. Repurposing of anticancer drugs for ageing-associated neurodegenerative disorderschud
  2. Specific pharmacological modulators of tau spreading for Alzheimer's disease preclinical studies
  3. Identifying druggable targets conferring selective advantages to protein misfolding and aggregation – example of tau aggregation 
  4. Developing physiologically relevant cellular models – 3D cell cultures, organotypic slice cultures (brain and lungs) and human iPSCs.
ANNADURAI, N., J. DE SANCTIS, M. HAJDÚCH, V. DAS
Tau secretion and propagation: Perspectives for potential preventive interventions in Alzheimer's disease and other tauopathies. Experimental Neurology. 2021, 343, 113756, ISSN: 0014-4886, PMID: 33989658,
Projekt: The role of tumor hypoxia in the emergence of acquired resistance to drugs aimed at microtubules
Vedoucí: Das Viswanath M.Sc., Ph.D.
K dispozici: 1
Určeno pro: Doktorské studium
Souhrn: 1 place in full-time study
Projekt: Generation of 3D human neuronal cultures: application to modeling CNS diseases
Vedoucí: Das Viswanath M.Sc., Ph.D.
K dispozici: 1
Určeno pro: Magisterské studium
Souhrn: -
Projekt: Biochemical and cellular analysis of amyloid staining agents in models of tauopathies and synucleopathies
Vedoucí: Das Viswanath M.Sc., Ph.D.
K dispozici: 1
Určeno pro: Magisterské studium
Souhrn: -
Projekt: Investigating Effects of Aggregates of Intrinsically Disordered Proteins on Microglia: Implication for Neurodegenerative Diseases
Vedoucí: Das Viswanath M.Sc., Ph.D.
K dispozici: 1
Určeno pro: Magisterské studium
Souhrn: -
Projekt: Efficacy of Bruton Tyrosine Kinase Inhibitors Against Neuroinflammation in Neurodegenerative Diseases
Vedoucí: Das Viswanath M.Sc., Ph.D.
K dispozici: 1
Určeno pro: Magisterské studium
Souhrn: -
Projekt: Systems approaches to understanding aging and neurodegeneration
Vedoucí: Das Viswanath M.Sc., Ph.D.
K dispozici: 2
Určeno pro: Doktorské studium
Projekt: Role of axonal transport and pathology in neurodegeneration
Vedoucí: Das Viswanath M.Sc., Ph.D.
K dispozici: 2
Určeno pro: Doktorské studium
Projekt: Research and development of agents for cancer, neurodegenerative and infectious diseases
Vedoucí: De Sanctis Juan Bautista Ph.D., Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D., Urban Milan Ph.D., Das Viswanath M.Sc., Ph.D.
K dispozici: 5
Určeno pro: Doktorské studium
ÚMTM, LEM, POSTDOKTORSKÝ STUDENT, PERSONÁL
ÚMTM, LEM, MAGISTERSKÝ STUDENT
BAKALÁŘSKÝ STUDENT, ÚMTM, LEM
ÚMTM, LEM, PERSONÁL
DOKTORSKÝ STUDENT, ÚMTM, LEM, MAGISTERSKÝ STUDENT, PERSONÁL
ÚMTM, LEM, MAGISTERSKÝ STUDENT
ÚMTM, LEM, MAGISTERSKÝ STUDENT
ÚMTM, LEM, MAGISTERSKÝ STUDENT