Ručilová Veronika Ph.D.

Ručilová Veronika Ph.D.'s picture
Phone: 585 632 189
Curriculum Vitae: download
Doctoral training
Development of Strategies for Solid-Phase Synthesis of Nitrogenous Heterocyclic Compounds Based on the 2- and 4-Nitrobenzenesulfonamide Chemistry
The submitted doctoral thesis deals with the development of simple procedures applicable for the preparation of libraries of selected heterocyclic compounds. In all of the introduced procedures, the immobilized 2- or 4-nitrobenzenesulfonamides were used as the key intermediates. Different scenarios have been used in which the nitrobenzenesulfonyl (Nos) group was applied (1) only as a protective/activating group for Fukuyama selective monoalkylation followed by the cleavage of the sulfonamide scaffold, (2) as a building block after previous Fukuyma alkylation, or (3) as a building block without application of Fukuyama alkylation. The key intermediates were further modified and converted to the target products under different cyclization conditions. During our long-term research we have developed high-throughput solid-phase syntheses of various heterocyclic compounds involving six types of different scaffolds.



Publications (Impact Factor Journals):

  • [14]
    KRÁLOVÁ, P., V. RUČILOVÁ a M. SOURAL. Polymer-Supported Syntheses of Heterocycles Bearing Oxazine and Thiazine Scaffolds. ACS Combinatorial Science. 2018, 20(9), 529-543. ISSN 2156-8952. IF: 3.500. PMID: 30040392
  • [13]
    VANDA, D., M. SOURAL, V. CANALE, S. CHAUMONT-DUBEL, G. SATALA, T. KOS, P. FUNK, V. RUČILOVÁ, B. LEMROVÁ, K. P., E. PEKALA, A. BOJARSKI, P. POPIK, P. MARIN a P. ZAJDEL. Novel non-sulfonamide 5-HT6 receptor partial inverse agonist in a group of imidazo[4,5-b]pyridines with cognition enhancing properties. European Journal of Medicinal Chemistry. 2017, 144(2018), 716-729. ISSN 0223-5234. IF: 4.519. PMID: 29291439
  • [12]
    KRÁLOVÁ, P., M. MALOŇ, T. VOLNÁ, V. RUČILOVÁ a M. SOURAL. Polymer-Supported Stereoselective Synthesis of Benzoxazino[4,3-b][1,2,5]thiadiazepinone 6,6-dioxides. ACS Combinatorial Science. 2017, 19(10), 670-674. ISSN 2156-8952. IF: 3.168. PMID: 28825802
  • [11]
    KRÁLOVÁ, P., V. FÜLÖPOVÁ, M. MALOŇ, T. VOLNÁ, I. POPA a M. SOURAL. Stereoselective Polymer-Supported Synthesis of Morpholine- and Thiomorpholine-3-carboxylic Acid Derivatives. ACS Combinatorial Science. 2017, 19(3), 173-180. ISSN 2156-8952 . IF: 3.317. PMID: 28085245
  • [10]
    FÜLÖPOVÁ, V. a M. SOURAL. Mining the Chemical Space: Application of 2/4-Nitrobenzenesulfonamides in Solid-Phase Synthesis. ACS Combinatorial Science. 2015, 17(10), 570-591. ISSN 2156-8952. IF: 3.317. PMID: 26325251
  • [9]
    FÜLÖPOVÁ, V., L. CZIESLA, M. FLEMING, Y. LU, A. VOELKER a V. KRCHŇÁK. Traceless Solid-Phase Synthesis of Trisubstituted Quinazolines. ACS Combinatorial Science. 2015, 17(8), 470-473. ISSN 2156-8952. IF: 3.317. PMID: 26145229
  • [8]
    FÜLÖPOVÁ, V., A. KRCHNAKOVA, E. SCHUTZNEROVA, J. ZAJICEK a V. KRCHŇÁK. Ring Contraction of 2,5-Dihydrobenzo[f][1,2,5]thiadiazepine 1,1-Dioxides: Access to 4H-Benzo[b][1,4]thiazine 1,1-Dioxides. Journal of Organic Chemistry. 2015, 80(3), 1795-1801. ISSN 1520-6904. IF: 4.785. PMID: 25564930
  • [7]
    FÜLÖPOVÁ, V. a V. KRCHŇÁK. Solid-Phase Synthesis of Trisubstituted 2,5-Dihydrobenzo[f][1,2,5]thiadiazepine 1,1-Dioxide Derivatives. ACS Combinatorial Science. 2014, 16(8), 412-420. ISSN 2156-8952. IF: 3.032. PMID: 24884092
  • [6]
    MCMASTER, C., V. FÜLÖPOVÁ, I. POPA, M. GREPL a M. SOURAL. Solid-Phase Synthesis of Anagrelide Sulfonyl Analogues. ACS Combinatorial Science. 2014, 16(5), 221-224. ISSN 2156-8952. IF: 3.032. PMID: 24725158
  • [5]
    FÜLÖPOVÁ, V., T. GUCKÝ, M. GREPL a M. SOURAL. Solid-Phase Synthesis of Trisubstituted Benzo[1,4]-Diazepin-5-one Derivatives. ACS Combinatorial Science. 2012, 14(12), 651-656. ISSN 2156-8952. IF: 3.636. PMID: 23145965
  • [4]
    FÜLÖPOVÁ, V., P. FUNK, I. POPA, C. MCMASTER a M. SOURAL. Solid-Phase Synthesis of Trisubstituted Benzo[f][1,2,3]triazolo[1,5-a][1,4]- diazepin-6(5H)-ones and Their Sulfonyl Analogues under Mild Reaction Conditions. European Journal of Organic Chemistry. 2015, 16(-), 3551-3557. ISSN 1434-193X. IF: 3.068.
  • [3]
    FÜLÖPOVÁ, V. a M. SOURAL. Solid-Phase Synthesis of Heterocycles with -Haloketones as the Key Building Blocks. Synthesis-Stuttgart. 2016, 48(21), 3684. ISSN 0039-7881. IF: 2.650.
  • [2]
    RUČILOVÁ, V., P. KRÁLOVÁ a M. SOURAL. Synthesis of Disubstituted Pyrazino-Oxazine Derivatives with Controlled Stereochemistry. European Journal of Organic Chemistry. 2017, 47, 7034-7039. ISSN 1434-193X. IF: 2.834.
  • [1]
    RUČILOVÁ, V., M. MALOŇ a M. SOURAL. Use of Triethylsilane for Directed Enantioselective Reduction of Olefines: Synthesis of Pyrazino[2,1-c][1,4]oxazine-6,9-diones with Full Control of the Absolute Configuration. European Journal of Organic Chemistry. 2018, 4, 564-570. ISSN 1434-193X . IF: 2.834.

Book Chapters:

  • [1]
    RUČILOVÁ, V. a M. SOURAL. Solid-Phase Synthesis of Seven-Membered Heterocycles with Two Nitrogen Atoms. In: Topics in Heterocyclic Chemistry. x. x: Springer International Publishing, 2017. Kapitola 52, s. 23-63. ISBN: 978-3-642-15454-6.

Master students mentor:

[2] Petra Králová, Solid-Phase Synthesis of Novel Morpholine/Thiomorpholine-3-Carboxylic Acid Derivatives ,
status: Graduated, from: 2014 to 2016
[1] Richard Hekele, Synthesis of trisubstituted derivatives of 4H-benzo triazole diazepin one on solid phase using an alpha-amino acid,
status: Graduated, from: 2014 to 2016

Bachelor students mentor:

[2] Zuzana Balová, Synthesis of S-imidazopyridines with potential dual PDE4 / PDE7 activity,
status: Ongoing, from: 2016
[1] Renáta Páníková, Synthesis of derivatives of imidazopyridine,
status: Ongoing, from: 2016