Moudrý Pavel Ph.D.

Moudrý Pavel Ph.D.'s picture
Academic Title: Ing.
Phone: +420 585 632 234

Laboratory of Genome Integrity


Twitter: @Bartek_Lab



Open Positions

Positions for undergraduate students and for highly-motivated PhD students are available. Topics include DNA damage response and ribosomal biogenesis. Feel free to contact me for detailed information.




Maya-Mendoza A*, Moudry P*, Merchut-Maya JM, Lee M, Strauss R, Bartek J

High speed of fork progression induces DNA replication stress and genomic instability​​

Nature 2018 Jul 12; 559:(7713)279-284

*These authors contributed equally to this work



Skrott Z, Mistrik M, Andersen KK, Friis S, Majera D, Gursky J, Ozdian T, Bartkova J, Turi Z, Moudry P, Kraus M, Michalova M, Vaclavkova J, Dzubak P, Vrobel I, Pouckova P, Sedlacek J, Miklovicova A, Kutt A, Li J, Mattova J, Driessen C, Dou QP, Olsen J, Hajduch M, Cvek B, Deshaies RJ, Bartek J

Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4​​

Nature 2017 Dec 14; 552:(7684)194 - 199


Turi Z, Senkyrikova M, Mistrik M, Bartek J, Moudry P

Perturbation of RNA Polymerase I transcription machinery by ablation of HEATR1 triggers the RPL5/RPL11-MDM2-p53 ribosome biogenesis stress checkpoint pathway in human cells

Cell Cycle 2018 Jan 16; 17:(1)92-101


Ozdian T, Holub D, Maceckova Z, Varanasi L, Rylova G, Rehulka J, Vaclavkova J, Slavik H, Moudry P, Znojek P, Stankova J, Bautista de Sanctis J, Hajduch M, Dzubak P

Proteomic profiling reveals DNA damage, nucleolar and ribosomal stress are the main responses to oxaliplatin treatment in cancer cells

Journal of Proteomics 2017 Jun 6; 162:73 - 85


Chroma K, Mistrik M*, Moudry P*, Gursky J, Liptay M, Strauss R, Skrott Z, Vrtel R, Bartkova J, Kramara J, Bartek J

Tumors overexpressing RNF168 show altered DNA repair and responses to genotoxic treatments, genomic instability and resistance to proteotoxic stress

Oncogene 2017 Apr 27; 36(17):2405 - 2422

*These authors contributed equally to this work 


Moudry P, Watanabe K, Wolanin KM, Bartkova J, Wassing IE, Watanabe S, Strauss R, Troelsgaard Pedersen R, Oestergaard VH, Lisby M, Andújar-Sánchez M, Maya-Mendoza A, Esashi F, Lukas J, Bartek J

TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity

Journal of Cell Biology 2016 Feb 1; 212(3):281 - 288 

Paper also featured in JCB's​ Special Collections: The Year in Cell Biology and DNA replication, recombination and repair


Frankum J*, Moudry P*, Brough R, Hodny Z, Ashworth A, Bartek J, Lord CJ

Complementary genetic screens identify the E3 ubiquitin ligase CBLC, as a modifier of PARP inhibitor sensitivity

Oncotarget 2015 May 10; 6(13):10746 - 107458

*These authors contributed equally to this work


Moudry P, Lukas C, Macurek L, Neumann B, Heriche JK, Pepperkok R, Ellenberg J, Hodny Z, Lukas J, Bartek J

Nucleoporin NUP153 guards genome integrity by promoting nuclear import of 53BP1

Cell Death &​ Differentiation 2012 May; 19(5):798 - 807


Moudry P, Lukas C, Macurek L, Hanzlikova H, Hodny Z, Lukas J, Bartek J

Ubiquitin-activating enzyme UBA1 is required for cellular response to DNA damage

Cell Cycle 2012 Apr 15; 11(8):1573 - 1582


Hamerlik P, Lathia JD, Rasmussen R, Wu Q, Bartkova J, Lee M, Moudry P, Bartek J Jr, Fischer W, Lukas J, Rich JN, Bartek J

Autocrine VEGF-VEGFR2-Neuropilin-1 signaling promotes glioma stem-like cell viability and tumor growth

Journal of Experimental Medicine 2012 Mar 12; 209(3):507 - 520


Bartkova J, Moudry P, Hodny Z, Lukas J, Rajpert-De Meyts E, Bartek J

Heterochromatin marks HP1γ, HP1α and H3K9me3, and DNA damage response activation in human testis development and germ cell tumours

International Journal of Andrology 2011 Aug; 34(4 Pt2):e103 - 113


Blazkova H, Krejcikova K, Moudry P, Frisan T, Hodny Z, Bartek J

Bacterial intoxication evokes cellular senescence with persistent DNA damage and cytokine signalling

Journal of Cellular and  Molecular Medicine 2010 Jan; 14(1-2):357 - 367

Publications (Impact Factor Journals):

Doctoral students mentor:

[1] Zsofia Turi, Replication stress induced cellular senescence in primary fibroblast cell lines,
Ph.D. specialization: , status: Ongoing, from: 2014

Master students mentor:

[1] Barbora Haroková, Ribosomal stress and activation of p53,
status: Ongoing, from: 2016

Bachelor students mentor:

[1] Ondřej Šanovec, Cellular response to ribosomal stress,
status: Ongoing, from: 2017