Chromá Katarína M.Sc.
Academic Title: Mgr
Phone: +420 585632232
Curriculum Vitae: download
Using novel anti-cancer agents in elucidation of DNA damage response (DDR) mechanisms and their role in onset of cancer
The thesis is centered on cellular responses, termed DNA damage response (DDR) to DNA double-strand breaks, presumably the most deleterious lesions affecting DNA. The aim of the thesis is to shed more light on certain mechanistic aspects of the DDR. To this end, several chemical inhibitors interfering with different key steps of the DDR are utilized. Apart from deciphering the underlying mechanisms, this approach might lead to new diagnostic and therapeutic approaches.
Supervisor:Kramara Juraj Ph.D.
Publications (Impact Factor Journals):
- CHROMÁ, K., M. MISTRÍK, P. MOUDRÝ, J. GURSKÝ, M. LIPTAY, R. STRAUSS, Z. ŠKROTT, R. VRTEL, J. BARTKOVA, J. KRAMARA a J. BÁRTEK. Tumors overexpressing RNF168 show altered DNA repair and responses to genotoxic treatments, genomic instability and resistance to proteotoxic stress. Oncogene. 2017, 36(17), 2405-2422. ISSN 0950-9232 . IF: 7.932. PMID: 27841863
- BÉRESOVÁ, L., E. VESELÁ, I. CHAMRAD, J. VOLLER, M. YAMADA, T. FÜRST, R. LENOBEL, K. CHROMÁ, J. GURSKÝ, K. KŘÍŽOVÁ, M. MISTRÍK a J. BÁRTEK. Role of DNA Repair Factor Xeroderma Pigmentosum Protein Group C in Response to Replication Stress As Revealed by DNA Fragile Site Affinity Chromatography and Quantitative Proteomics. Journal of Proteome Research. 2016, 15(12), 4505-4517. ISSN 1535-3893 . IF: 4.268. PMID: 27794614