Urban Milan Ph.D.

Journals

KAZAKOVA, A., I. FRYDRYCH, N. JAKUBCOVÁ, J. POKORNÝ, B. LIŠKOVÁ, S. GURSKÁ, P. DŽUBÁK, M. HAJDÚCH, M. URBAN
Novel triterpenoid pyrones, phthalimides and phthalates are selectively cytotoxic in CCRF-CEM cancer cells - Synthesis, potency, and mitochondrial mechanism of action. European Journal of Medicinal Chemistry. 2024, 269, 116336, ISSN: 0223-5234, PMID: 38520761,  PDF.
BORKOVÁ, L., I. FRYDRYCH, B. VRÁNOVÁ, N. JAKUBCOVÁ, B. LIŠKOVÁ, P. DŽUBÁK, P. PAVLIŠ, M. HAJDÚCH, M. URBAN
Lupane derivatives containing various aryl substituents in the position 3 have selective cytostatic effect in leukemic cancer cells including resistant phenotypes. European Journal of Medicinal Chemistry. 2022, 244, 114850, ISSN: 0223-5234, PMID: 36283179,
HODOŇ, J., I. FRYDRYCH, Z. TRHLÍKOVÁ, J. POKORNÝ, L. BORKOVÁ, S. BENICKÁ, M. VLK, B. LIŠKOVÁ, A. KUBÍČKOVÁ, M. MEDVEDÍKOVÁ, M. PISÁR, J. ŠAREK, V. DAS, A. LIGASOVÁ, K. KOBERNA, P. DŽUBÁK, M. HAJDÚCH, M. URBAN
Triterpenoid pyrazines and pyridines - Synthesis, cytotoxicity, mechanism of action, preparation of prodrugs. European Journal of Medicinal Chemistry. 2022, 243, 114777, ISSN: 0223-5234, PMID: 36174412,  PDF.

Doctoral mentorship

Borková Lucie Ph.D.

Modification of triterpenes with the use of transition metal catalyzed reactions and nucleophilic substitution

Stav: Absolvoval od 2014 do 2018.
Pokorný Jan Ph.D.

Modifications of double bonds in triterpenes with antitumor activity

Stav: Absolvoval od 2015 do 2022.
Hodoň Jiří, Ph.D.

Cytotoxic active triterpenes and their mechanism of action

Stav: Absolvoval od 2017 do 2024.

Master mentorship

Olejníková Denisa

Synthesis of new lupane derivatives modified at position 20 or 30

Stav: Absolvoval od 2018 do 2020.
Šidová Veronika

Synthesis of new cytotoxic triterpenoid derivatives using click chemistry

Stav: Absolvoval od 2013 do 2015.
Zoufalý Pavel

Exploraton of click reaction approach in triterpenoids containing propargyl substituent

Stav: Absolvoval od 2014 do 2016.

Bachelor mentorship

Horka Vladimír

Conjugates of betulin prepared by cycloaddition reactions

Stav: Absolvoval od 2016 do 2018.
Olejníková Denisa

Synthesis of new lupane derivatives modified at position 20 or 30

Stav: Absolvoval od 2016 do 2018.
Orság Šimon

Preparation of new heterocyclic derivatives of triterpene

Stav: Absolvoval od 2018 do 2020.

Open positions

Projekt: Research and development of agents for cancer, neurodegenerative and infectious diseases
Vedoucí: De Sanctis Juan Bautista Ph.D., Hajdúch Marián M.D., Ph.D., Džubák Petr M.D., Ph.D., Urban Milan Ph.D., Das Viswanath M.Sc., Ph.D.
K dispozici: 5
Určeno pro: Doktorské studium