Kocourková Lenka M.Sc.
Phone: +420 588444242
Effect of coregulators on the androgen receptor activity in cells derived from prostate cancer after their treatment with histone deacetylase inhibitor
The thesis is focused on the detection of coregulator expressions in cancer and normal prostate cells. Coregulators, coactivators as well as coregulators, play an important role in androgen receptor-mediated progression of the prostate cancer. There is a competition between coactivators and corepressors for binding on the androgen receptor and therefore, the changes and the expression ratio between could be important for prostate cancer growth and progression. We focus on two regulators: SMRT (silencing mediator for retinoid and thyroid hormone receptors) as corepressor, and p300 as coactivator.
Supervisor:Smešný Trtková Kateřina Ph.D.
Publications (Impact Factor Journals):
- PETŘEK, M., L. KOCOURKOVÁ, V. ŽIŽKOVÁ, Z. NOSEK, M. TABORSKY a J. PETŘKOVÁ. Characterization of three CYP2C19 gene variants by Mass Array and Point of care techniques - experience from a Czech centre. Archivum Immunologiae et Therapiae Experimentalis. 2016, 64, 99-107. ISSN 0004-069X. IF: 2.040. PMID: 28083610
- KISHORE, A., V. ŽIŽKOVÁ, L. KOCOURKOVÁ, J. PETŘKOVÁ, E. BOUROS, H. NUNES, V. LOSTAKOVA, J. MÜLLER-QUERNHEIM, G. ZISSEL, V. KOLEK, D. BOUROS, D. VALEYRE a M. PETŘEK. Association Study for 26 Candidate Loci in Idiopathic Pulmonary Fibrosis Patients from Four European Populations. Frontiers in Immunology. 2016, 7(-), 274. ISSN 1664-3224 . IF: 6.429. PMID: 27462317
- KISHORE, A., V. ŽIŽKOVÁ, L. KOCOURKOVÁ a M. PETŘEK. A dataset of 26 candidate gene and pro-inflammatory cytokine variants for association studies in idiopathic pulmonary fibrosis: frequency distribution in normal Czech population. Frontiers in Immunology. 2015, 6(476), article number: 476. ISSN 1664-3224. IF: 5.695. PMID: 26441981