Contakt

Žižkovičová Patrícia

Academic Title: Mgr.
Phone: +420 585632070
Groups: Doctoral Student, Staff, LEM

Doctoral training

Molecular and cellular changes in the process of aging.

Somatic mutations occur during aging in cells. Most of these mutations are harmless and passively accumulate in the human body. However, some somatic mutations obtained at the beginning of growth may cause developmental disorders and their accumulation is also responsible for the formation of cancer and may contribute to the aging process. As the sensitivity of methods for detection of low-frequency mutations has evolved, it is now possible to monitor the development of clonal mutations and to understand their occurrence in normal cells, respectively their connection with the development of the pathological state. The aim of the dissertation thesis is to monitor population aging and collection of acquired clonal mutations using deep whole exome sequencing and panel sequencing.

Specialization: Oncology.
Status: Ongoing from 2019.
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