Contakt

Chromá Katarína Ph.D.

Academic Title: Mgr
Phone: +420 585632234
Groups: Staff, LIG, Doctoral Student
Curriculum Vitae: curriculum_vitae_b.pdf

Doctoral training

Using novel anti-cancer agents in elucidation of DNA damage response (DDR) mechanisms and their role in onset of cancer.

The thesis is centered on cellular responses, termed DNA damage response (DDR) to DNA double-strand breaks, presumably the most deleterious lesions affecting DNA. The aim of the thesis is to shed more light on certain mechanistic aspects of the DDR. To this end, several chemical inhibitors interfering with different key steps of the DDR are utilized. Apart from deciphering the underlying mechanisms, this approach might lead to new diagnostic and therapeutic approaches.

Supervisor:
Specialization: Medical genetics.
Status: Graduated from 2012 to 2017.

About me

My research is focused on mechanisms of DNA damage response (DDR) in connection to either disrupted protein homeostasis or DNA replication. Another aspect of my study aims at understanding of cancer cell vulnerabilities for better guidance of existing anticancer treatments as well as the drug-repurposing strategies.
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