Opened topics

New topics of bachelor's theses at IMTM LF UP for the academic year 2021/2022 in the cooperation with CGB laboratories Ostrava, within the project “Analysis of Czech genomes for theranostics” (www.acgt.cz) with the possibility of thesis elaboration and holiday practice in CGB laboratories Ostrava, as

1. Detection of MED12 mutations and selected cytogenetic changes in cervical myomas
Supervisor: MUDr. Josef Srovnal, Ph.D. (IMTM LF UP, josef.srovnal@upol.cz)
Professional supervisor: RNDr. Magdalena Uvirova, Ph.D. (CGB Ostrava, uvirova@pathology.cz)
Number of students: 1
Bachelor training

2. Revision of the variants of unclear significance (VUS) in patients tested for hereditary cancer syndromes in the context of the results of the A-C-G-T project
Supervisor: MUDr. Josef Srovnal, Ph.D. (IMTM LF UP, josef.srovnal@upol.cz)
Professional supervisor: RNDr. Magdalena Uvirova, Ph.D. (CGB Ostrava, uvirova@pathology.cz)
Number of students: 1
Bachelor training

3. Analysis of genetic changes in tumors of prostate cancer patients
Supervisor: MUDr. Josef Srovnal, Ph.D. (IMTM LF UP, josef.srovnal@upol.cz)
Professional supervisor: RNDr. Magdalena Uvirova, Ph.D. (CGB Ostrava, uvirova@pathology.cz)
Number of students: 1
Bachelor training

4. Detection of somatic mutations and selected cytogenetic changes in gliomas
Supervisor: MUDr. Josef Srovnal, Ph.D. (IMTM LF UP, josef.srovnal@upol.cz)
Professional supervisor: RNDr. Magdalena Uvirova, Ph.D. (CGB Ostrava, uvirova@pathology.cz)
Number of students: 1
Bachelor training

Drug synergy studies in 3D spheroids cultures of tumour cell lines
Supervisor: Viswanath Das, PhD (viswanath.das@upol.cz
Number of student(s): 2
Bachelor training /Master training     

Development of organoid assays for anti-tumour drug screening
Supervisor: Viswanath Das, PhD (viswanath.das@upol.cz
Number of student(s): 2
Bachelor training /Master training    

Biochemical and cellular analysis of amyloid staining agents in models of tauopathies and synucleopathies
Supervisor: Viswanath Das, PhD (viswanath.das@upol.cz
Number of students: 2
Bachelor and Master training   

Small animal imaging using microPET/SPECT/CT system in preclinical developement of potential drugs
Supervisor: Mgr. Zbyněk Nový, Ph.D.
Number of students: 1
Bachelor training/ Master training

In vivo imaging of 68Ga labelled biomolecules
Supervisor: PharmDr. Miloš Petřík, PhD.
Number of students: 1
Bachelor training
 
Radiolabelled siderophores for infection imaging
Supervisor: PharmDr. Miloš Petřík, PhD.
Number of students: 1
Master training
 
Radiolabelled peptides for cancer imaging
Supervisor: PharmDr. Miloš Petřík, PhD.
Number of students: 1
Master training

Development and characterization of resistant cell lines to purine and pyrimidine cytotoxic drugs.
Supervisor: MUDr. Petr Džubák, Ph.D.
Number of students: 1
Master training

Lipidomic analysis of exhaled breath condensate 
Supervisor: prof. Juan B. De Sanctis, PhD
Number of students: 1
Master training 

Antigen presentation and immune response in cancer
Supervisor: prof. Juan B. De Sanctis, PhD
Number of students: 2
Bachelor training  

Lipidomics aanalysis of exhaled breath condensate
Supervisor: prof. Juan B. De Sanctis, PhD
Number of students: 1
Bachelor training    

Fragment-based de novo design using pharmacophore models 
Pavlo Polishchuk, Ph.D.,M.Sc.
Number of students: 1
Master training

Novel 3D pharmacophore representation for machine learning 
Pavlo Polishchuk, Ph.D.,M.Sc.
Number of students: 1
Master training

Computationally guided optimization of compound properties
Pavlo Polishchuk, Ph.D.,M.Sc.
Number of students: 1
Master training 

Applicability domains in machine learning modeling
Pavlo Polishchuk, Ph.D.,M.Sc.
Number of students: 1
Master training 

Genetic biomarkers
prof. Mgr. Jiří Drábek, Ph.D.
Number of students: 1
Master training 

Epigenetic biomarkers
prof. Mgr. Jiří Drábek, Ph.D.
​Number of students: 1
Master training 

Identification of small molecule cell cycle modulators
Mgr. Jiří Řehulka, Ph.D.
Number of students: 0
Bachelor training/ Master training