Laboratory of Genome Integrity

Research in the LIG focuses on various mechanistic aspects of the DNA damage response and DNA repair pathways. Both pathways play a key role in the onset and progress of cancer and thus represent ideal targets for novel anti-cancer drugs. In addition we endeavor to understand how elevated replication stress in rapidly growing pre-cancerous and cancerous cells affects the progression of the disease. We would also like to understand in detail how the cell copes with replication stress at the molecular level. Our long term goal is to set up specific DDR response based high throughput screens capable of assessing the effect of different compounds and environmental conditions on DNA integrity in human cells. In our research we employ state-of-the-art equipment including the Carl Zeiss Super resolution and Spinning Disc microscopic systems.

Impact Factor Journals

KANELLIS, D., A. ZISI, Z. ŠKROTT, B. LEMMENS, J. ESPINOZA, M. KOSAR, A. BJÖRKMAN, X. LI, S. ARAMPATZIS, J. BARTKOVA, M. ANDUJAR-SANCHEZ, O. FERNANDEZ-CAPETILLO, M. MISTRÍK, M. LINDSTROM a J. BÁRTEK. Actionable cancer vulnerability due to translational arrest, p53 aggregation and ribosome biogenesis stress evoked by the disulfiram metabolite CuET. Cell Death and Differentiation. 2023, -, -, ISSN 1350-9047, IF: 12.073, PMID: 37142656
BUCHTOVÁ, T., L. BÉRESOVÁ, K. CHROMÁ, T. PLUHACEK, T. BERES, D. KACZOROVA, P. TARKOWSKI, J. BÁRTEK a M. MISTRÍK. Cannabis-derived products antagonize platinum drugs by altered cellular transport. Biomedicine & Pharmacotherapy. 2023, 163, 114801, ISSN 0753-3322, IF: 7.419, PMID: 37137184
BUCHTOVÁ, T., D.. LUKÁČ, Z. ŠKROTT, K. CHROMÁ, J. BÁRTEK a M. MISTRÍK. Drug-Drug Interactions of Cannabidiol with Standard-of-Care Chemotherapeutics. International Journal of Molecular Sciences. 2023, 24(3), 2885, ISSN 1422-0067, IF: 6.208, PMID: 36769206 Dedication: CZ.02.1.01/0.0/0.0/16_019/0000868, 20-28685S, IGA_LF_2022_038, DNRF 12, LX22NPO5102 PDF
LUKÁČ, D.., Z. MACHAČOVÁ a P. MOUDRÝ. Emetine blocks DNA replication via proteosynthesis inhibition not by targeting Okazaki fragments. Life Science Alliance. 2022, 5(12), e202201560, ISSN 2575-1077, IF: 5.781, PMID: 36260751
GIALLONGO, S., D. REHAKOVA, T. BIAGINI, O. LO RE, P. RAINA, G. LOCHMANOVA, Z. ZDRAHAL, I. RESNICK, P. PATA, M. MISTRÍK, J. DE MAGALHAES, T. MAZZA, I. KOUTNA a M. VINCIGUERRA. Histone Variant macroH2A1.1 Enhances Nonhomologous End Joining-dependent DNA Double-strand-break Repair and Reprogramming Efficiency of Human iPSCs. Stem Cells. 2022, 40(1), 35-48, ISSN 1066-5099, IF: 6.277, PMID: 35511867
PAUN, R., D. DUMUT, A. CENTORAME, T. THURAISINGAM, M. HAJDÚCH, M. MISTRÍK, P. DŽUBÁK, J.B. DE SANCTIS, D. RADZIOCH a M. TABRIZIAN. One-Step Synthesis of Nanoliposomal Copper Diethyldithiocarbamate and Its Assessment for Cancer Therapy. Pharmaceutics. 2022, 14(3), 640, ISSN 1999-4923, IF: 6.321, PMID: 35336014 Dedication: TIPS-CRC-232667, CZ.02.1.01/0.0/0.0/16_019/0000868, EATRIS-CZ Account No.7283 PDF DATA
CHROMÁ, K., Z. ŠKROTT, J. GURSKÝ, J. BACOVSKY, P. MOUDRÝ, T. BUCHTOVÁ, M. MISTRÍK a J. BÁRTEK. A drug repurposing strategy for overcoming human multiple myeloma resistance to standard-of-care treatment. Cell Death & Disease. 2022, 13(3), 203, ISSN 2041-4889, IF: 8.469, PMID: 35246527
KUDLOVÁ, N., H. SLAVÍK, P. DUŠKOVÁ, T. FÜRST, J. SROVNAL, J. BÁRTEK, M. MISTRÍK a M. HAJDÚCH. An efficient, non-invasive approach for in-vivo sampling of hair follicles: design and applications in monitoring DNA damage and aging. Aging. 2021, 13(23), 25004-25024, ISSN 1945-4589, IF: 5.682, PMID: 34874896
RAFFAELE, M., K. KOVACOVICOVA, T. BIAGINI, O. LO RE, J. FROHLICH, S. GIALLONGO, J. NHAN, A. GIANNONE, D. CABIBI, M. IVANOV, A. TONCHEV, M. MISTRÍK, M. LACEY, P. DŽUBÁK, S. GURSKÁ, M. HAJDÚCH, J. BÁRTEK, T. MAZZA, V. MICALE, S. CURRAN a M. VINCIGUERRA. Nociceptin/orphanin FQ opioid receptor (NOP) selective ligand MCOPPB links anxiolytic and senolytic effects. Geroscience. 2021, 44(1), 463-483, ISSN 2509-2715, IF: 7.713, PMID: 34820764
BUCHTOVÁ, T., Z. ŠKROTT, K. CHROMÁ, J. ŘEHULKA, P. DŽUBÁK, M. HAJDÚCH, D.. LUKÁČ, S. ARAMPATZIS, J. BÁRTEK a M. MISTRÍK. Cannabidiol-induced activation of the metallothionein pathway impedes anticancer effects of disulfiram and its metabolite CuET. Molecular Oncology. 2021, 16(7), 1541-1554, ISSN 1574-7891, IF: 6.603, PMID: 34632694
MOUDRÝ, P., K. CHROMÁ, S. BURSAC, S. VOLAREVIC a J. BÁRTEK. RNA-interference screen for p53 regulators unveils a role of WDR75 in ribosome biogenesis. Cell Death and Differentiation. 2022, 29(3), 687-696, ISSN 1350-9047, IF: 15.828, PMID: 34611297
MIČKOVÁ, A., G. KHARAISHVILI, D. KURFÜRSTOVÁ, M. GACHECHILADZE, M. KRAL, O. VACEK, B. POKRYVKOVA, M. MISTRÍK, K. SOUCEK a J. BOUCHAL. Skp2 and Slug Are Coexpressed in Aggressive Prostate Cancer and Inhibited by Neddylation Blockade. International Journal of Molecular Sciences. 2021, 22(6), 2844, ISSN 1422-0067, IF: 4.556, PMID: 33799604 Dedication: NU20-03-00201, 17-28518A, 00098892, LF_2021_005, CZ.02.1.01/0.0/0.0/16_019/0000868, CZ.1.05/2.1.00/19.0400, LM2018129, DRO 61989592 PDF
MISTRÍK, M., Z. ŠKROTT, P. MULLER, A. PANACEK, L. HOCHVALDOVA, K. CHROMÁ, T. BUCHTOVÁ, V. VANDOVA, L. KVÍTEK a J. BÁRTEK. Microthermal-induced subcellular-targeted protein damage in cells on plasmonic nanosilver-modified surfaces evokes a two-phase HSP-p97/VCP response. Nature Communications. 2021, 12(1), 713, ISSN 2041-1723, IF: 12.121, PMID: 33514738
MINARIK, J., T. PIKA, J. RADOCHA, A. JUNGOVA, J. STRAUB, T. JELINEK, L. POUR, P. PAVLICEK, M. MISTRÍK, L. BROZOVA, P. KRHOVSKA, K. MACHALKOVA, P. JINDRA, I. SPICKA, H. PLONKOVA, M. STORK, J. BACOVSKY, L. CAPKOVA, M. SYKORA, P. KESSLER, L. STEJSKAL, A. HEINDORFER, J. ULLRYCHOVA, T. SKACEL, V. MAISNAR a R. HAJEK. Survival benefit of ixazomib, lenalidomide and dexamethasone (IRD) over lenalidomide and dexamethasone (Rd) in relapsed and refractory multiple myeloma patients in routine clinical practice. BMC Cancer. 2021, 21(1), 73, ISSN 1471-2407, IF: 3.150, PMID: 33451293
TAUBER, Z., K. CHROMÁ, R. BARANOVA a K. ČÍŽKOVÁ. The expression patterns of IL-1β and IL-10 and their relation to CYP epoxygenases in normal human placenta. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft. 2021, 236(2021), 151671, ISSN 0940-9602, IF: 2.388, PMID: 33440233
MAJERA, D. a M. MISTRÍK. Effect of Sepatronium Bromide (YM-155) on DNA Double-Strand Breaks Repair in Cancer Cells. International Journal of Molecular Sciences. 2020, 21(24), 9431, ISSN 1422-0067, IF: 4.556, PMID: 33322336 Dedication: CZ.02.1.01/0.0/0.0/16_019/0000868, TN01000013, IGA-LF-2020-023 PDF
CHYRA, Z., T. SEVCIKOVA, P. VOJTA, J. PUTEROVA, L. BROZOVA, K. GROWKOVA, J. FILIPOVA, M. ZATOPKOVA, S. GROSICKI, A. BARCHNICKA, W. JEDRZEJCAK, A. WASCUK-GAJDA, A. JUNGOVA, A. MIKULASOVA, M. HAJDÚCH, M. MOKREJS, L. POUR, M. STORK, L. HARVANOVA, M. MISTRÍK, G. MIKALA, P. ROBAK, A. CZYZ, J. DEBSKI, L. USNARSKA-ZUBKIEWICZ, A. JURCZYSZYN, L. STEJSKAL, G. MORGAN, F. KRYUKOV, E. BUDINSKA, M. SIMICEK, T. JELINEK, M. HRDINKA a R. HAJEK. Heterogenous mutation spectrum and deregulated cellular pathways in aberrant plasma cells underline molecular pathology of light-chain amyloidosis. Haematologica. 2020, 106(2), 601-604, ISSN 0390-6078, IF: 7.570, PMID: 32381580
MAJERA, D., Z. ŠKROTT, K. CHROMÁ, J. MERCHUT-MAYA, M. MISTRÍK a J. BÁRTEK. Targeting the NPL4 Adaptor of p97/VCP Segregase by Disulfiram as an Emerging Cancer Vulnerability Evokes Replication Stress and DNA Damage while Silencing the ATR Pathway. Cells. 2020, 9(2), pii: E469, ISSN 2073-4409, IF: 5.656, PMID: 32085572 Dedication: 17-25976S, LM2018129, CZ.02.1.01/0.0/0.0/16_013/0001775, IGA_LF_2019_026, CZ.02.1.01/0.0/0.0/16_019/0000868, DNRF125, R204-A12617, VR-MH 2014-46602-117891-30, 170176 PDF
ČÍŽKOVÁ, K., P. FLODROVÁ, R. BARANOVA, J. MALOHLAVA, M. LACEY a Z. TAUBER. Beneficial Effect of Heat-induced Antigen Retrieval in Immunocytochemical Detection of Intracellular Antigens in Alcohol-fixed Cell Samples. Applied Immunohistochemistry and Molecular Morphology. 2020, 28(2), 166-174, ISSN 1541-2016, IF: 1.863, PMID: 32044886
ŠKROTT, Z., D. MAJERA, J. GURSKÝ, T. BUCHTOVÁ, M. HAJDÚCH, M. MISTRÍK a J. BÁRTEK. Disulfiram's anti-cancer activity reflects targeting NPL4, not inhibition of aldehyde dehydrogenase. Oncogene. 2019, 38(40), 6711-6722, ISSN 0950-9232, IF: 6.634, PMID: 31391554
TURI, Z., M. LACEY, M. MISTRÍK a P. MOUDRÝ. Impaired ribosome biogenesis: mechanisms and relevance to cancer and aging. Aging-US. 2019, 11(8), 2512-2540, ISSN 1945-4589, IF: 5.179, PMID: 31026227
VANCUROVA, M., H. HANZLIKOVA, L. KNOBLOCHOVA, J. KOSLA, D. MAJERA, M. MISTRÍK, K. BURDOVA, Z. HODNY a J. BÁRTEK. PML nuclear bodies are recruited to persistent DNA damage lesions in an RNF168-53BP1 dependent manner and contribute to DNA repair. DNA Repair. 2019, 78, 114-127, ISSN 1568-7864, IF: 4.461, PMID: 31009828
TAUBER, Z., K. ČÍŽKOVÁ, R. LICHNOVSKA, M. LACEY, B. ERDÖSOVÁ, R. ZIZKA a V. KAMARAD. Evaluation of the Effectiveness of the Presentation of Virtual Histology Slides by Students During Classes. Are There Any Differences in Approach Between Dentistry and General Medicine Students?. European Journal of Dental Education. 2019, 23(2), 119-126, ISSN 1396-5883, IF: 1.343, PMID: 30582772
MAJERA, D., Z. ŠKROTT, J. BOUCHAL, J. BARTKOVA, D. ŠIMKOVÁ, M. GACHECHILADZE, J. STEIGEROVÁ, D. KURFÜRSTOVÁ, J. GURSKÝ, G. KOŘÍNKOVÁ, K. CWIERTKA, Z. HODNY, M. MISTRÍK a J. BÁRTEK. Targeting genotoxic and proteotoxic stress-response pathways in human prostate cancer by clinically available PARP inhibitors, vorinostat and disulfiram. The Prostate. 2018, 79(4), 352-362, ISSN 0270-4137, IF: 3.347, PMID: 30499118
KOVACICOVA, K., M. SKOLNAJA, M. HEINMAA, M. MISTRÍK, P. PATA, I. PATA, J. BÁRTEK a M. VINCIGUERRA. Senolytic Cocktail Dasatinib+Quercetin (D+Q) Does Not Enhance the Efficacy of Senescence-Inducing Chemotherapy in Liver Cancer. Frontiers in Oncology. 2018, 8, 459, ISSN 2234-943X, IF: 4.416, PMID: 30425964 Dedication: CZ.02.1.01/0.0/0.0/15_003/0000492 PDF
ČÍŽKOVÁ, K., P. FLODROVÁ, R. BARANOVA, J. MALOHLAVA, M. LACEY a Z. TAUBER. Beneficial Effect of Heat-induced Antigen Retrieval in Immunocytochemical Detection of Intracellular Antigens in Alcohol-fixed Cell Samples. Applied immunohistochemistry & Molecular Morphology. 2018, 28(2), 166-174, ISSN 1541-2016, IF: 2.042, PMID: 30095458
MAYA-MENDOZA, A., P. MOUDRÝ, J. MERCHUT-MAYA, M. LEE, R. STRAUSS a J. BÁRTEK. High speed of fork progression induces DNA replication stress and genomic instability. Nature. 2018, 559(7713), 279-284, ISSN 0028-0836, IF: 41.577, PMID: 29950726
ŠKROTT, Z., M. MISTRÍK, K. ANDERSEN, S. FRIIS, D. MAJERA, J. GURSKÝ, T. OŽDIAN, J. BARTKOVA, Z. TURI, P. MOUDRÝ, M. KRAUS, M. MEDVEDÍKOVÁ, J. VÁCLAVKOVÁ, P. DŽUBÁK, I. VROBEL, P. POUCKOVA, J. SEDLACEK, A. MIKLOVICOVA, A. KUTT, J. MATTOVA, C. DRIESSEN, Q. DOU, J. OLSEN, M. HAJDÚCH, B. CVEK, R. DESHAIES a J. BÁRTEK. Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4. Nature. 2017, 552(7684), 194-199, ISSN 0028-0836, IF: 40.137, PMID: 29211715
TURI, Z., M. ŠENKYŘÍKOVÁ, M. MISTRÍK, J. BÁRTEK a P. MOUDRÝ. Perturbation of RNA Polymerase I transcription machinery by ablation of HEATR1 triggers the RPL5/RPL11-MDM2-p53 ribosome biogenesis stress checkpoint pathway in human cells. Cell Cycle. 2017, 17(1), 92-101, ISSN 1538-4101, IF: 3.530, PMID: 29143558
PACULOVA, H., J. KRAMARA, S. SIMECKOVA, R. FEDR, K. SOUCEK, O. HYLSE, K. PARUCH, M. SVOBODA, M. MISTRÍK a J. KOHOUTEK. BRCA1 or CDK12 loss sensitizes cells to CHK1 inhibitors. Tumor Biology. 2017, 39(10), 1010428317727479, ISSN 1010-4283, IF: 3.650, PMID: 29025359 Dedication: NT14599-3/2013, 16-34152A, LQ1605, 15-33999A, LM2015063, LO1304, 7F14061 PDF
OŽDIAN, T., D. HOLUB, Z. MACEČKOVÁ, L. VARANASI, G. RYLOVÁ, J. ŘEHULKA, J. VÁCLAVKOVÁ, H. SLAVÍK, P. MOUDRÝ, P. ZNOJEK, J. STANKOVÁ, J.B. DE SANCTIS, M. HAJDÚCH a P. DŽUBÁK. Proteomic profiling reveals DNA damage, nucleolar and ribosomal stress are the main responses to oxaliplatin treatment in cancer cells. Journal of Proteomics. 2017, 162, 73-85, ISSN 1874-3919 , IF: 3.867, PMID: 28478306
VESELÁ, E., K. CHROMÁ, Z. TURI a M. MISTRÍK. Common Chemical Inductors of Replication Stress: Focus on Cell-Based Studies. Biomolecules. 2017, 7(1), pii: E19, ISSN 2218-273X , IF: 2.127, PMID: 28230817 Dedication: 13-17555S, IGA_LF_2016_030, CZ09 (Project PHOSCAN 7F14061) PDF
CHROMÁ, K., M. MISTRÍK, P. MOUDRÝ, J. GURSKÝ, M. LIPTAY, R. STRAUSS, Z. ŠKROTT, R. VRTEL, J. BARTKOVA, J. KRAMARA a J. BÁRTEK. Tumors overexpressing RNF168 show altered DNA repair and responses to genotoxic treatments, genomic instability and resistance to proteotoxic stress. Oncogene. 2017, 36(17), 2405-2422, ISSN 0950-9232 , IF: 7.932, PMID: 27841863
BÉRESOVÁ, L., E. VESELÁ, I. CHAMRAD, J. VOLLER, M. YAMADA, T. FÜRST, R. LENOBEL, K. CHROMÁ, J. GURSKÝ, K. KŘÍŽOVÁ, M. MISTRÍK a J. BÁRTEK. Role of DNA Repair Factor Xeroderma Pigmentosum Protein Group C in Response to Replication Stress As Revealed by DNA Fragile Site Affinity Chromatography and Quantitative Proteomics. Journal of Proteome Research. 2016, 15(12), 4505-4517, ISSN 1535-3893 , IF: 4.268, PMID: 27794614
KURFÜRSTOVÁ, D., J. BARTKOVA, R. VRTEL, A. MIČKOVÁ, A. BURDOVA, D. MAJERA, M. MISTRÍK, M. KRAL, F.R. SANTER, J. BOUCHAL a J. BÁRTEK. DNA damage signalling barrier, oxidative stress and treatment-relevant DNA repair factor alterations during progression of human prostate cancer. Molecular Oncology. 2016, 10(6), 879-894, ISSN 1574-7891, IF: 5.314, PMID: 26987799
MOUDRÝ, P., K. WATANABE, K. WOLANIN, J. BARTKOVA, I. WASSING, S. WATANABE, R. STRAUSS, R.S. PEDERSEN, V. OESTERGAARD, M. LISBY, M. ANDUJAR-SANCHEZ, A. MAYA-MENDOZA, F. ESASHI, J. LUKÁŠ a J. BÁRTEK. TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity. Journal of Cell Biology. 2016, 212(3), 281-288, ISSN 0021-9525 , IF: 7.955, PMID: 26811421
MISTRÍK, M., E. VESELÁ, T. FÜRST, H. HANZLIKOVA, I. FRYDRYCH, J. GURSKÝ, D. MAJERA a J. BÁRTEK. Cells and Stripes: A novel quantitative photo-manipulation technique. Scientific Reports. 2016, 6(-), Article Number: 19567, ISSN 2045-2322, IF: 4.259, PMID: 26777522
KOMIS, G., M. MISTRÍK, O. SAMAJOVA, M. OVECKA, J. BÁRTEK a J. SAMAJ. Superresolution live imaging of plant cells using structured illumination microscopy. Nature Protocols. 2015, 10(8), 1248-1263, ISSN 1754-2189, IF: 9.646, PMID: 26203822
MISTRÍK, M. a J. BÁRTEK. Editorial Material_ What a 'Ku'incidence!: parallel discoveries of a new DNA repair factor. Cell Death and Differentiation. 2015, 22(6), 888-889, ISSN 1350-9047, IF: IF (2014): 8.184, PMID: 25941165
XU, G., J. CHAPMAN, I. BRANDSMA, J. YUAN, M. MISTRÍK, P. BOUWMAN, J. BARTKOVA, E. GOGOLA, D. WARMERDAM, M. BAZARAS, J. JASPERS, K. WATANABE, M. PIETERSE, K. KERSBERGEN, W. SOL, P. CELIE, P. SCHOUTEN, B. VAN DEN BROEK, A. SALMAN, M. NIEUWLAND, I. DE RINK, J. DE RONDE, K. JALINK, S. BOULTON, J. CHEN, D. VAN GENT, J. BÁRTEK, J. JONKERS, P. BORST a S. ROTTENBERG. REV7 counteracts DNA double-strand break resection and affects PARP inhibition. Nature. 2015, 521(7553), 541-544, ISSN 0028-0836, IF: 38.138, PMID: 25799992
FUGGER, K., M. MISTRÍK, K. NEELSEN, Q. YAO , R. ZELLWEGER, A. KOUSHOLT, P. HAAHR, W. CHU, J. BÁRTEK, M. LOPES, I. HICKSON a C. SORENSEN. FBH1 Catalyzes Regression of Stalled Replication Forks. Cell Reports. 2015, 10(10), 1749-1757, ISSN 2211-1247, IF: 7.870, PMID: 25772361 Dedication: Novo Nordisk Foundation , Danish Cancer Society , Lundbeck Foundation , Association for International Cancer Research , European Research Council , Nordea Foundation , LO1304, VG20102014001 , Villum Kann Rasmussen Fund , Danish National Research Foundation , Danish Medical Research Council , Swiss National Science Foundation , Krebsliga Schweiz PDF
KANU, N., E. GRONROOS, P.. MARTINEZ, R.A. BURRELL, X.Y. GOH, J. BARTKOVA, A. MAYA-MENDOZA, M. MISTRÍK, A.J. ROWAN, H. PATEL, A. RABINOWITZ, P. EAST, G. WILSON, C.R. SANTOS, N. MCGRANAHAN, S. GULATI, M. GERLINGER, N.J. BIRKBAK, T. JOSHI, L.B. ALEXANDROV, M.R. STRATTON, T. POWLES, N. MATTHEWS, P.A. BATES, A. STEWART, Z. SZALLASI, J. LARKIN, J. BÁRTEK a C. SWANTON. SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair. Oncogene. 2015, 34(46), 5699-5708, ISSN 0950-9232, IF: 7.932, PMID: 25728682
MAYA-MENDOZA, A., J. OSTRAKOVA, M. KOSAR, A. HALL., P. DUŠKOVÁ, M. MISTRÍK, J. MERCHUT-MAYA, Z. HODNY, J. BARTKOVA, C. CHRISTENSEN a J. BÁRTEK. Myc and Ras oncogenes engage different energy metabolism programs and evoke distinct patterns of oxidative and DNA replication stress. Molecular Oncology. 2015, 9(3), 601-616, ISSN 1574-7891, IF: 5.367, PMID: 25435281
CHRISTENSEN, C., J. BARTKOVA, M. MISTRÍK, A. HALL., M.K. LANGE, U. RALFKIÆR, J. BÁRTEK a P. GULDBERG. A short acidic motif in ARF guards against mitochondrial dysfunction and melanoma susceptibility. Nature Communications. 2014, 5(5348), -, ISSN 2041-1723, IF: 11.470, PMID: 25370744
KOLÁŘ, M., M. HTOUTOU SEDLAKOVA, V. PUDOVA, M. RÖDEROVÁ, J. NOVOSAD, M. ŠENKYŘÍKOVÁ, R. SZOTKOWSKA a K. INDRAK. Incidence of fecal Enterobacteriaceae producing broad-spectrum beta-lactamases in patients with hematological malignancies. Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czech Republic. 2014, 159(1), 100-103, ISSN 1213-8118, IF: 1.200, PMID: 25270106
OKA, Y., H. VARMARK, K. VITTING-SEERUP, P. BELI, J. WAAGE, A. HAKOBYAN, M. MISTRÍK, C. CHOUDHARY, M. ROHDE, S. BEKKER-JENSEN a N. MAILAND. UBL5 is essential for pre-mRNA splicing and sister chromatid cohesion in human cells. EMBO Reports. 2014, 15(9), 956-964, ISSN 1469-221X, IF: 9.055, PMID: 25092792
KUMAR, A., M. MAZZANTI, M. MISTRÍK, M. KOSAR, G.V. BEZNOUSSENKO, A.A. MIRONOV, M. GARRE, D. PARAZZOLI, G. SHIVASHANKAR, G. SCITA, J. BÁRTEK a M. FOIANI. ATR Mediates a Checkpoint at the Nuclear Envelope in Response to Mechanical Stress. Cell. 2014, 158(3), 633-646, ISSN 0092-8674, IF: 32.242, PMID: 25083873
JANSA, P., D. HOMOLKA, R. BLATNY, M. MISTRÍK, J. BÁRTEK a J. FOREJT. Dosage Compensation of an Aneuploid Genome in Mouse Spermatogenic Cells. Biology of Reproduction. 2014, 90(6), Article Number: 124, ISSN 0006-3363, IF: 3.318, PMID: 24790161
KOMIS, G., M. MISTRÍK, O. SAMAJOVA, A. DOSKOCILOVA, M. OVECKA, P. ILLES, J. BÁRTEK a J. SAMAJ. Dynamics and Organization of Cortical Microtubules as Revealed by Superresolution Structured Illumination Microscopy. Plant Physiology. 2014, 165(1), 129-148, ISSN 0032-0889, IF: 6.841, PMID: 24686112
BHATTACHARYYA, T., R. REIFOVA, S. GREGOROVA, P. SIMECEK, V. GERGELITS, M. MISTRÍK, I. MARTINCOVA, J. PIALEK a J. FOREJT. X Chromosome Control of Meiotic Chromosome Synapsis in Mouse Inter-Subspecific Hybrids. PLOS Genetics. 2014, 10(2), -, ISSN 1553-7404, IF: 7.528, PMID: 24516397 Dedication: 13-08078S, LD11079, CZ.1.05/1.100/02.0109, 72109, SV/4118 PDF
YAMADA, M., K. WATANABE, M. MISTRÍK, E. VESELÁ, I. PROTIVÁNKOVÁ, N. MAILAND, M. LEE, H. MASAI, J. LUKÁŠ a J. BÁRTEK. ATR-Chk1-APC/CCdh1-dependent stabilization of Cdc7-ASK (Dbf4) kinase is required for DNA lesion bypass under replication stress. Genes & Development. 2013, 27(22), 2459-2472, ISSN 0890-9369, IF: 12.639, PMID: 24240236
BÁRTEK, J., M. MISTRÍK a J. BARTKOVA. Androgen receptor signaling fuels DNA repair and radioresistance in prostate cancer. Cancer Discovery. 2013, 3(11), 1222-1224, ISSN 2159-8274, IF: 15.929, PMID: 24203954
MISTRÍK, M. a J. KRAMARA. DNA damage-related ubiquitinations: one E1 that rules them all. Cell Cycle. 2012, 11(10), 1872-1877, ISSN 1538-4101, IF: 5.321, PMID: 22580454
FALCK, J., J. FORMENT, J. COATES, M. MISTRÍK, J. LUKÁŠ, J. BÁRTEK a S.P. JACKSON. CDK targeting of NBS1 promotes DNA-end resection, replication restart and homologous recombination. EMBO Reports. 2012, 13(6), 561-568, ISSN 1469-221X, IF: 7.189, PMID: 22565321
MOUDRÝ, P., C. LUKAS, L. MACUREK, H. HANZLIKOVA, Z. HODNY, J. LUKÁŠ a J. BÁRTEK. Ubiquitin-activating enzyme UBA1 is required for cellular response to DNA damage. Cell Cycle. 2012, 11(8), 1573-1582, ISSN 1538-4101, IF: 5.321, PMID: 22456334
HAMERLIK, P., J. LATHIA, R. RASMUSSEN, B. WU, J. BARTKOVA, M. LEE, P. MOUDRÝ, J.J. BARTEK, W. FISCHER, J. LUKÁŠ, J.N. RICH a J. BÁRTEK. Autocrine VEGF-VEGFR2-Neuropilin-1 signaling promotes glioma stem-like cell viability and tumor growth. Journal of Experimental Medicine. 2012, 209(3), 507-520, ISSN 0022-1007, IF: 13.214, PMID: 22393126
BÁRTEK, J., M. MISTRÍK a J. BARTKOVA. Thresholds of replication stress signaling in cancer development and treatment. Nature Structural & Molecular Biology. 2012, 19(1), 5-7, ISSN 1545-9993, IF: 11.902, PMID: 22218289
JORDA, R., L. HAVLICEK, I.W. MCNAE, M.D. WALKINSHAW, J. VOLLER, A. STURC, J. NAVRATILOVA, M. KUZMA, M. MISTRÍK, J. BÁRTEK, M. STRNAD a V. KRYŠTOF. Pyrazolo[4,3-d]pyrimidine Bioisostere of Roscovitine: Evaluation of a Novel Selective Inhibitor of Cyclin-Dependent Kinases with Antiproliferative Activity. Journal of Medicinal Chemistry. 2011, 54(8), 2980-2993, ISSN 0022-2623, IF: 5.248, PMID: 21417417
LÖFFLER, H., A. FECHTER, M. MATUSZEWSKA, R. SAFFRICH, M. MISTRÍK, J. MARHOLD, C. HORNUNG, F. WESTERMANN, J. BÁRTEK a A. KRÄMER. Cep63 Recruits Cdk1 to the Centrosome: Implications for Regulation of Mitotic Entry, Centrosome Amplification, and Genome Maintenance. Cancer Research. 2011, 71(6), 2129-2139, ISSN 0008-5472, IF: 7.856, PMID: 21406398
BÁRTEK, J., M. MISTRÍK a J. BARTKOVA. Long-distance inflammatory and genotoxic impact of cancer in vivo. Proceedings of the National Academy of Sciences of the United States of America. 2010, 107(42), 17861-17862, ISSN 0027-8424, IF: 9.771, PMID: 20926747
HUBACKOVA, S., Z. NOVAKOVA, K. KREJCIKOVA, M. KOSAR, J. DOBROVOLNA, P. DUŠKOVÁ, H. HANZLIKOVA, M. VANCUROVA, P. BARATH, J. BÁRTEK a Z. HODNY. Regulation of the PML tumor suppressor in drug-induced senescence of human normal and cancer cells by JAK/STAT-mediated signaling. Cell Cycle. 2010, 9(15), 3085-3099, ISSN 1538-4101, IF: 4.999, PMID: 20699642
HODNY, Z., M. MISTRÍK a J. BÁRTEK. HERCulean giant orchestrates ubiquitin-mediated signaling on damaged chromosomes. Cell Cycle. 2010, 9(7), 1227-1228, ISSN 1538-4101, IF: 4.999, PMID: 20234179
MISTRÍK, M. a J. BÁRTEK. Cyclin D3-dependent kinases in lymphoma: redundancy and implications for therapy. Cell Cycle. 2010, 9(3), 446-447, ISSN 1538-4101, IF: 4.999, PMID: 20130452
BRULÍKOVÁ, L., S. KŘUPKOVÁ, M. LABORA, K. MOTYKA, L. HRADILOVÁ, M. MISTRÍK, J. BÁRTEK a J. HLAVÁČ. Synthesis and study of novel pH-independent fluorescent mitochondrial labels based on Rhodamine B. RSC Advances. 2016, 6(28), 23242-23251, ISSN 2046-2069 , IF: 3.108,
OKOROCHENKOV, S., Z. ŠKROTT, D. MAJERA, M. PORUBSKÝ, M. MISTRÍK a J. HLAVÁČ. BODIPY-aza-indole derivate complex as a selective fluorescent sensor for autolysosomes detection. Sensors and Actuators B-Chemical. 2022, 351, 130941, ISSN 0925-4005, IF: 7.46,
DUMUT, D., J.B. DE SANCTIS, M. MISTRÍK, Z. ŠKROTT, P. DŽUBÁK, J. BÁRTEK, M. HAJDÚCH a D. RADZIOCH. ?chybi pdf_Meeting abstract_Dithiocarb-copper complex, CuET, demonstrates anti-neoplastic activity in mouse model of prostate cancer and prevents recurrence of tumors. Cance Research. 2021, 81(13), 1251, ISSN 0008-5472, IF: 12.701,

Other Reviewed Journals

ŠENKYŘÍKOVÁ, M., V. HUSICKOVA, M. CHROMA, P. SAUER, J. BARDOŇ a M. KOLÁŘ. Acinetobacter baumannii producing OXA-23 detected in the Czech Republic. SpringerPlus. 2013, 2(1), 296. ISSN 2193-1801. PMID: 23 888 268
Project: Study of DNA double-strand break repair in tumor model
Supervisors: Mistrík Martin Ph.D.
Available: 1
Intended for: Doctoral training

The so-called double-strand breaks (DSB) are the most lethal DNA lesions, which can be potent sources of mutations and thus become the beginning of irreversible genetic changes leading to degenerative illnesses, including cancer. At the same induction of DSBs introduced in the proper setup can become an unsolvable problem for the cells, particularly in specific genetic backgrounds typical for cancer, which fact is the rationale for a plethora of cancer treatment strategies. Thus the way cells deal with DSBs is under the great interest of current medicinal and biological research. The Ph.D. student will practice several methods of induction of DSBs via various sources such as gamma rays, alpha particles, UV light and various chemical inducers. Next will be studied the molecular mechanisms the cell deal with this type of DNA damage. Emphasis will be put on differences between normal and cancer cells and their potential exploration for cancer therapy. Student will also learn mutiple laboratory techniques including cell culture, RNA/DNA transfections, advanced microscopic techniques, live-cell imaging, and various biochemical analysis of proteins.

Project: Signaling DNA damage in cellular response to stress
Supervisors: Mistrík Martin Ph.D.
Available: 1
Intended for: Doctoral training

Our DNA is constantly under threat from DNA damaging agents. If unrepaired DNA damage can lead to errors during genome duplication, including the mutations that can lead to cancer, contribute to aging and other human diseases. Cells have evolved elaborate repair mechanisms to fix this damage and ensure that the genetic information is faithfully reproduced, and we would like to understand these repair mechanisms at the molecular level. We ultimately aim for a complete molecular and cellular understanding of critical DNA repair pathways that act on DNA damage. The Ph.D. student will practice several molecular and cellular techniques, including cell culture, RNA interference, immunofluorescence microscopy, live-cell imaging and immunoprecipitation of proteins. He/she will also learn novel and powerful techniques, such as super-resolution microscopy and purification of proteins on newly synthesized DNA.

Project: DNA damage signaling in the cellular response to stress
Supervisors: Mistrík Martin Ph.D.
Available: 2
Intended for: Doctoral training
Project: Cellular stress in health and disease
Supervisors: Mistrík Martin Ph.D., Moudrý Pavel Ph.D., Škrott Zdeněk Ph.D.
Available: 3
Intended for: Doctoral training
Project: DNA damage signaling in the cellular response to stress
Supervisors: Mistrík Martin Ph.D.
Available: 1
Intended for: Doctoral training

1 place in full-time study

Laboratory head

Mistrík Martin Ph.D.

Research groups

DNA replication dynamics

Junior research group

Cellular stress

Senior research group