Jan Pokorný
Supervisor:
Urban Milan Ph.D.
Status: Graduated
Specialization:
Modifications of double bonds in triterpenes with antitumor activity
In this work, double bond of betulin, betulinic acid and other cytotoxic triterpenes will be modified by various methods. First method will be based on transition metal catalyzed crosscoupling reactions, of triterpenic boronic acids with a variety of other molecules. Second, aldehyde will be prepared in the neighborhood of the double bond and it will be condensed with a number of organic hydrazines, hydrazones, amines etc.