Králová Petra

Králová Petra's picture
Academic Title: M.Sc.
Master training
Solid-Phase Synthesis of Novel Morpholine/Thiomorpholine-3-Carboxylic Acid Derivatives
This diploma thesis deals with the preparation of novel morpholine/thiomorpholine-3-carboxylic acids derivatives with use of solid phase synthesis. The starting materials for the preparation of target compounds are four types of resin with acid-labile linkers, natural α-amino acids, sulfonyl chlorides, α-bromoacetophenones, carboxylic acids or their chlorides, trifluoroacetic acid and reducing agent (triethylsilane). The Theoretical section is devoted to the literature summarizing methods for the preparation of the target derivatives. In the Discussion part there are described issues concerning the preparation of the desired compounds. The Experimental section presents general procedures for the preparation and isolation of these derivatives followed by analytical data of the individual substances. The Conclusion part summarizes our results and their evaluation. In the last part, there are attached annexes of the prepared compounds.

Status:

Graduated 2014 - 2016

Publications (Impact Factor Journals):

  • [7]
    KRÁLOVÁ, P., V. RUČILOVÁ a M. SOURAL. Polymer-Supported Syntheses of Heterocycles Bearing Oxazine and Thiazine Scaffolds. ACS Combinatorial Science. 2018, -, -. ISSN 2156-8952. IF: 3.500. PMID: 30040392
  • [6]
    KRÁLOVÁ, P. a M. SOURAL. Synthesis of 2-Alkylsulfonyl-imidazoles with Three Diversity Positions from Immobilized α-Acylamino Ketones. ACS Combinatorial Science. 2018, 20(8), 467-471. ISSN 2156-8952. IF: 3.500. PMID: 29969011
  • [5]
    KRÁLOVÁ, P., M. MALOŇ, H. KOSHINO a M. SOURAL. Convenient Synthesis of Thiohydantoins, Imidazole-2-thiones and Imidazo[2,1-b]thiazol-4-iums from Polymer-Supported α-Acylamino Ketones. Molecules. 2018, 23(4), pii: E976. ISSN 1420-3049. IF: 2.861. PMID: 29690582
  • [4]
    KRÁLOVÁ, P., M. MALOŇ a M. SOURAL. Stereoselective Synthesis of Benzo[e][1,4]oxazino[4,3-a][1,4]diazepine-6,12-diones with Two Diversity Positions. ACS Combinatorial Science. 2017, -, -. ISSN 2156-8952. IF: 3.168. PMID: 29048877
  • [3]
    KRÁLOVÁ, P., M. MALOŇ, T. VOLNÁ, V. RUČILOVÁ a M. SOURAL. Polymer-Supported Stereoselective Synthesis of Benzoxazino[4,3-b][1,2,5]thiadiazepinone 6,6-dioxides. ACS Combinatorial Science. 2017, 19(10), 670-674. ISSN 2156-8952. IF: 3.168. PMID: 28825802
  • [2]
    KRÁLOVÁ, P., V. FÜLÖPOVÁ, M. MALOŇ, T. VOLNÁ, I. POPA a M. SOURAL. Stereoselective Polymer-Supported Synthesis of Morpholine- and Thiomorpholine-3-carboxylic Acid Derivatives. ACS Combinatorial Science. 2017, 19(3), 173-180. ISSN 2156-8952 . IF: 3.317. PMID: 28085245
  • [1]
    RUČILOVÁ, V., P. KRÁLOVÁ a M. SOURAL. Synthesis of Disubstituted Pyrazino-Oxazine Derivatives with Controlled Stereochemistry. European Journal of Organic Chemistry. 2017, 47, 7034-7039. ISSN 1434-193X. IF: 2.834.