Annadurai Narendran M.Sc.

Annadurai Narendran M.Sc.'s picture
Phone: +420 775 094 851

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Doctoral training
Tau aggregation inhibitors in the treatment of neurodegenerative diseases
Understanding the mechanism of tau aggregation, propagation and cellular machinery involved in aggregated tau degradation would help in identifying therapeutic targets for tauopathies (Alzheimer’s disease, PSP, CTE, FTLD, etc.) and other neurodegenerative diseases. The thesis is focused on studying tau aggregate spreading mechanisms, identifying small molecule inhibitors of tau misfolding and aggregation using in vitro aggregation assays, cell biology, biochemistry and microscopy techniques.

Status:

Ongoing

Publications (Impact Factor Journals):



Bachelor students mentor:

[1] Jiří Hrubý, Studying the role of tunneling nanotubes in cell-to-cell transfer of tau aggregates: Implications in tauopathies,
status: Ongoing, from: 2018