Annadurai Narendran M.Sc.
Phone: +420 775 094 851
Kinase inhibitors in the treatment of neurodegenerative diseases
My Research thesis is focused on the identification of potential inhibitors of kinases involved in the tau hyperphosphorylation mediated tau aggregation induced tauopathy in neurodegenerative diseases, in particular Alzheimer’s disease (AD). The study will shed further insight into the role of disease-specific kinases in the pathogenesis of AD. The study involves screening of small molecule inhibitors of kinases as well as tau aggregation and their characterization in in vitro and in vivo models of AD.
Supervisor:Das Viswanath M.Sc., Ph.D.
Status:Ongoing 2015 - 2015
Publications (Impact Factor Journals):
- ŘEHULKA, J., N. ANNADURAI, I. FRYDRYCH, P. ZNOJEK, P. DŽUBÁK, P. NORTHCOTE, J.H. MILLER, M. HAJDÚCH a V. DAS. Cellular effects of the microtubule-targeting agent peloruside A in hypoxia-conditioned colorectal carcinoma cells. Biochimica et Biophysica Acta. 2017, 17, 30124-1. ISSN 0304-4165. IF: 5.083. PMID: 28366502