Mádrová Lucie M.Sc

Mádrová Lucie M.Sc's picture
Phone: +420 585632176
Doctoral training
Study of the effect of selected cancerostatics on the cell metabolome
The thesis is focused on the development of both targeted and untargeted metabolomics methods (liquid chromatography coupled with high resolution mass spectrometry) for the study of the effects of various anticancer drugs on model cell lines. The main goal is to quantitatively analyse changes in metabolome’s composition for the comprehensive characterization of metabolic networks.

Supervisor:

Adam Tomáš Ph.D.

Status:

Ongoing

Publications (Impact Factor Journals):

  • [4]
    MÁDROVÁ, L., M. KRIJT, V. BARESOVA, J. VÁCLAVÍK, D. FRIEDECKÝ, D. DOBEŠOVÁ, O. SOUCKOVA, V. SKOPKOVA, T. ADAM a M. ZIKANOVA. Mass spectrometric analysis of purine de novo biosynthesis intermediates. PLOS One. 2018, 13(12), e0208947. ISSN 1932-6203. IF: 2.766. PMID: 30532129
  • [3]
    KARLÍKOVÁ, R., J. ŠIROKÁ, M. MECH, D. FRIEDECKÝ, H. JANEČKOVÁ, L. MÁDROVÁ, F. HRDINOVA, Z. DRABKOVA, O. DOBESOVA, T. ADAM a P. JAHN. Newborn foal with atypical myopathy. Journal of Veterinary Internal Medicine. 2018, 32(5), 1768-1772. ISSN 0891-6640. IF: 2.185. PMID: 30216546
  • [2]
    VÁCLAVÍK, J., K. COENE, I. VROBEL, L. NAJDEKR, D. FRIEDECKÝ, R. KARLÍKOVÁ, L. MÁDROVÁ, A. PETSALO, U. ENGELKE, A. VAN WEGBERG, L. KLUIJTMANS, T. ADAM a R. WEVERS. Structural elucidation of novel biomarkers of known metabolic disorders based on multistage fragmentation mass spectra. Journal of Inherited Metabolic Disease. 2018, 41(3), 407-414. ISSN 0141-8955. IF: 3.970. PMID: 29139026
  • [1]
    NAJDEKR, L., A. GARDLO, L. MÁDROVÁ, D. FRIEDECKÝ, H. JANEČKOVÁ, E. CORREA, R. GOODACRE a T. ADAM. Oxidized phosphatidylcholines suggest oxidative stress in patients with medium-chain acyl-CoA dehydrogenase deficiency. Talanta. 2015, 139(2015), 62-66. ISSN 0039-9140. IF: 4.035. PMID: 25882409


Master students mentor:

[1] Dana Dobešová, Metabolic profiling of HeLa cells deficient in purine de novo synthesis,
status: Ongoing, from: 2018