Hodoň Jiří

Hodoň Jiří's picture
Bachelor training
Attempt to find the mechanizm of action in cytotoxic active triterpenes
Attempt to find the mechanizm of action in cytotoxic active triterpenes . The main goals of this work is to prepare a set of triterpenoid derivatives that have shown high selective cytotoxicity and synthesize biotinylated probes from them that may be used in pull down essays in order to try to find molecular targets.

Supervisor:

Urban Milan Ph.D.

Status:

Graduated 2012 - 2015

Publications (Impact Factor Journals):

  • [2]
    SOURAL, M., J. HODOŇ, N.J. DICKINSON, V. ŠIDOVÁ, S. GURSKÁ, P. DŽUBÁK, M. HAJDÚCH, J. ŠAREK a M. URBAN. Preparation of Conjugates of Cytotoxic Lupane Triterpenes with Biotin. Bioconjugate Chemistry. 2015, 26(12), 2563-70. ISSN 1043-1802. IF: 4.818. PMID: 26537839
  • [1]
    BORKOVÁ, L., J. HODOŇ a M. URBAN. Synthesis of Betulinic Acid Derivatives with Modified A-Rings and their Application as Potential Drug Candidates. Asian Journal of Organic Chemistry. 2018, 7(8), 1542-1560. ISSN 2193-5807. IF: 2.496.