Šarek Jan Ph.D.

Šarek Jan Ph.D.'s picture
Academic Title: RNDr.

Publications (Impact Factor Journals):

  • [21]
    EIGNEROVA, B., M. TICHÝ, J. KRASULOVA, L. RAROVA, R. CHRISTOVÁ, M. URBAN, B. BEDNARCZYK-CWYNAR, M. HAJDÚCH a J. ŠAREK. Q1_Synthesis and antiproliferative properties of new hydrophilic esters of triterpenic acids. European Journal of Medicinal Chemistry. 2017, 140, 403-420. ISSN 0223-5234. IF: 4.519. PMID: 28987603
  • [20]
    BORKOVÁ, L., R. ADÁMEK, P. KALINA, P. DRAŠAR, P. DŽUBÁK, S. GURSKÁ, J. ŘEHULKA, M. HAJDÚCH, M. URBAN a J. ŠAREK. Synthesis and Cytotoxic Activity of Triterpenoid Thiazoles Derived from Allobetulin, Methyl Betulonate, Methyl Oleanonate, and Oleanonic Acid. ChemMedChem. 2017, 12(5), 390-398. ISSN 1860-7179 . IF: 2.980. PMID: 28084676
  • [19]
    BORKOVÁ, L., S. GURSKÁ, P. DŽUBÁK, R. BURIÁNOVÁ, M. HAJDÚCH, J. ŠAREK, I. POPA a M. URBAN. Lupane and 18α-oleanane derivatives substituted in the position 2, their cytotoxicity and influence on cancer cells. European Journal of Medicinal Chemistry. 2016, 121, 120-131. ISSN 0223-5234 . IF: 4.519. PMID: 27236068
  • [18]
    SOSVOROVA, L., J. ŠAREK, J. VITKU a M. KVASNICA. Synthesis of 3α-deuterated 7α-hydroxy-DHEA and 7-oxo-DHEA and application in LC-MS/MS plasma analysis. Steroids. 2016, 112(2016), 88-94. ISSN 0039-128X . IF: 2.282. PMID: 27192427
  • [17]
    SOURAL, M., J. HODOŇ, N.J. DICKINSON, V. ŠIDOVÁ, S. GURSKÁ, P. DŽUBÁK, M. HAJDÚCH, J. ŠAREK a M. URBAN. Preparation of Conjugates of Cytotoxic Lupane Triterpenes with Biotin. Bioconjugate Chemistry. 2015, 26(12), 2563-70. ISSN 1043-1802. IF: 4.818. PMID: 26537839
  • [16]
    KVASNICA, M., M. URBAN, N.J. DICKINSON a J. ŠAREK. Pentacyclic triterpenoids with nitrogen- and sulfur-containing heterocycles: synthesis and medicinal significance. Natural Product Reports. 2015, 20(32), 1303-1330. ISSN 0265-0568. IF: 10.986. PMID: 26030604
  • [15]
    BORKOVÁ, L., L. JASILKOVA, J. ŘEHULKA, K. FRISONSOVA, M. URBAN, I. FRYDRYCH, I. POPA, M. HAJDÚCH, N.J. DICKINSON, M. VLK, P. DŽUBÁK a J. ŠAREK. Synthesis of cytotoxic 2,2-difluoroderivatives of dihydrobetulinic acid and allobetulin and study of their impact on cancer cells. European Journal of Medicinal Chemistry. 2015, 96(-), 482-490. ISSN 0223-5234. IF: 3.902. PMID: 25942059
  • [14]
    URBAN, M., M. VLK, P. DŽUBÁK, M. HAJDÚCH a J. ŠAREK. Cytotoxic heterocyclic triterpenoids derived from betulin and betulinic acid. Bioorganic & Medicinal Chemistry. 2012, 20(11), 3666-3674. ISSN 0968-0896. IF: 2.903. PMID: 22551630
  • [13]
    URBAN, M., J. ŠAREK, M. KVASNICA, I. TIŠLEROVÁ a M. HAJDÚCH. Triterpenoid Pyrazines and Benzopyrazines with Cytotoxic Activity. Journal of Natural products. 2007, 70(4), 526-532. ISSN 0163-3864. IF: 2.418. PMID: 17371067
  • [12]
    DŽUBÁK, P., M. HAJDÚCH, D. VYDRA, A. HÚŠŤOVÁ, M. KVASNICA, D. BIEDERMANN, L. MARKOVÁ, M. URBAN a J. ŠAREK. Pharmacological activities of natural triterpenoids and their therapeutic implications. Natural Product Reports. 2006, 23(3), 394-411. ISSN 0265-0568. IF: 7.325. PMID: 16741586
  • [11]
    URBAN, M., J. ŠAREK, I. TIŠLEROVÁ, P. DŽUBÁK a M. HAJDÚCH. Influence of esterification and modification of A-ring in a group of lupane acids on their cytotoxicity. Bioorganic & Medicinal Chemistry. 2005, 13(19), 5527-5535. ISSN 0968-0896. IF: 2.018. PMID: 16087342
  • [10]
    ŠAREK, J., M. KVASNICA, M. URBAN, J. KLINOT a M. HAJDÚCH. Correlation of cytotoxic activity of betulinines and their hydroxy analogues. Bioorganic & Medicinal Chemistry Letters. 2005, 15(19), 4196-4200. ISSN 0960-894X. IF: 2.333. PMID: 16051489
  • [9]
    KVASNICA, M., J. ŠAREK, E. KLINOTOVÁ, P. DŽUBÁK a M. HAJDÚCH. Synthesis of phthalates of betulinic acid and betulin with cytotoxic activity. Bioorganic & Medicinal Chemistry. 2005, 13(10), 3447-54. ISSN 0968-0896. IF: 2.018. PMID: 15848757
  • [8]
    URBAN, M., J. ŠAREK, J. KLINOT, G. KOŘÍNKOVÁ a M. HAJDÚCH. Synthesis of A-seco derivatives of betulinic acid with cytotoxic activity. Journal of Natural Products. 2004, 67(7), 1100-1105. ISSN 0163-3864. IF: 1.849. PMID: 15270560
  • [7]
    ŠAREK, J., P. DŽUBÁK, E. KLINOTOVÁ, V. NOSKOVA, V. KŘEČEK, G. KOŘÍNKOVÁ, J.O. THOMSON, A. JANOŠŤÁKOVÁ, S. WANG, S. PARSONS, P.M. FISCHER, N. ZHELEV a M. HAJDÚCH. New lupane derived compounds with Pro-Apoptotic activity in cancer cells: Synthesis and structure-activity relationships. Journal of Medicinal Chemistry. 2003, 46(25), 5402-5415. ISSN 0022-2623. IF: 4.566. PMID: 14640549
  • [6]
    VLK, M., M. URBAN, T. ELBERT a J. ŠAREK. Synthesis of selectively deuterated and tritiated lupane derivatives with cytotoxic activity. Journal of Radioanalytical and Nuclear Chemistry. 2013, 298(2), 1149-1157. ISSN 0236-5731. IF: 1.415.
  • [5]
    BIEDERMANN, D., M. URBAN, M. BUDESINKY, M. KVASNICA a J. ŠAREK. Study of addition of difluorocarbene on double bond of triterpenes. Journal of Fluorine Chemistry. 2013, 148(-), 30-35. ISSN 0022-1139. IF: 1.952.
  • [4]
    VLK, M., P. MICOLOVA, M. URBAN, M. KVASNICA, D. SAMAN a J. ŠAREK. N-15-labelled pyrazines of triterpenic acids. Journal of Radioanalytical and Nuclear Chemistry. 2016, 308(2), 733-739. ISSN 0236-5731. IF: 1.282.
  • [3]
    DŽUBÁK, P., M. HAJDÚCH, D. VYDRA, A. HÚŠŤOVÁ, M. KVASNICA, D. BIEDERMANN, L. MARKOVÁ, M. URBAN a J. ŠAREK. Pharmacological activities of natural triterpenoids and their therapeutic implications. Natural Product Reports. 2006, 23, 394-411. ISSN 0265-0568. IF: 7.325.
  • [2]
    BIEDERMANN, D., J. ŠAREK, J. KLINOT, M. HAJDÚCH a P. DŽUBÁK. Fluorination of betulinines and other triterpenoids with DAST. Synthesis-Stuttgart. 2005, -(7), 1157-1163. ISSN 0039-7881. IF: 2.203.
  • [1]
    BORKOVÁ, L., R. ADÁMEK, P. KALINA, P. DRAŠAR, P. DŽUBÁK, S. GURSKÁ, J. ŘEHULKA, M. HAJDÚCH, M. URBAN a J. ŠAREK. Synthesis and Cytotoxic Activity of Triterpenoid Thiazoles Derived from Allobetulin, Methyl Betulonate, Methyl Oleanonate, and Oleanonic Acid. ChemMedChem. 2017, 12(5), 390-398. ISSN 1860-7179. IF: 3.225.

Book Chapters:

  • [2]
    URBAN, M., M. KVASNICA, N.J. DICKINSON a J. ŠAREK. Biologically Active Triterpenoids Usable As Prodrugs. In: Terpenoids and Squalene: Biosynthesis, Functions and Health Implications. 1. vyd. New York, USA: Nova Science Publishers, 2015. Kapitola 2, s. 25-50. ISBN: 978-1-63463-656-8.
  • [1]
    ŠAREK, J., M. KVASNICA, M. VLK, M. URBAN, P. DŽUBÁK a M. HAJDÚCH. The Potential of Triterpenoids in the Treatment of Melanoma. In: Research on Melanoma – A Glimpse into Current Directions and Future Trends. 1.vyd. Rijeka: InTech, 2011. Kapitola 7, s. 125-158. ISBN: 978-953-307-293-7.

Patents, Utility models & other IP's :

[1] PROCESS FOR PREPARING INCLUSION COMPLEX OF PENTACYCLIC AND TETRACYCLIC TERPENOIDS, PROCESS FOR PREPARING PHARMACEUTICAL COMPOSITION CONTAINING THIS INCLUSION COMPLEX, INCLUSION COMPLEX OF PENTACYCLIC OR TETRACYCLIC TERPENOID AND PHARMACEUTICAL COMPOSITION, Priority Appl. CZ PV 2006-606
  1. Patent: CZ 300 722, Granted: 13. 5. 2009, Ownership: Charles University Prague, Palacky University Olomouc, I.Q.A., Inventors: Šarek Jan, Hajdúch Marián, Svoboda Michal, Nováková Kateřina
  2. Patent: US 8,653,056, Granted: 18. 2. 2014, Ownership: Charles University Prague, Palacky University Olomouc, I.Q.A., Inventors: Šarek Jan, Hajdúch Marián, Svoboda Michal, Nováková Kateřina, Spáčilová Pavla, Kubelka Tomáš, Biedermann David
  3. Patent: CA 2 666 437, Granted: 24. 4. 2012, Ownership: Charles University Prague, Palacky University Olomouc, I.Q.A., Inventors: Šarek Jan, Hajdúch Marián, Svoboda Michal, Nováková Kateřina, Spáčilová Pavla, Kubelka Tomáš, Biedermann David
  4. Patent: CA 2 762 911, Granted: 5. 11. 2013, Ownership: Charles University Prague, Palacky University Olomouc, I.Q.A., Inventors: Šarek Jan, Hajdúch Marián, Svoboda Michal, Nováková Kateřina, Spáčilová Pavla, Kubelka Tomáš, Biedermann David
  5. Patent: EP 2068882, Granted: 23. 08. 2017, Ownership: Charles University Prague, Palacky University Olomouc, I.Q.A., Inventors: Šarek JanHajdúch Marián, Svoboda Michal, Nováková Kateřina, Spáčilová Pavla, Kubelka Tomáš, Biedermann David

Status: Available