Nová Alice Ph.D.

Nová Alice Ph.D.'s picture
Academic Title: PharmDr.
Phone: +420 585632334, +420 585632244
Curriculum Vitae: download
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Researcher experienced in the field of early ADME (absorption, distribution, metabolism and excretion) profiling of drug candidates.

Research interests: determination of in vitro ADME properties of NCEs (new chemical entities), i.e. assessment of NCEs GIT permeability, identification of P-glycoprotein substrates, prediction of blood brain barrier permeability, determination of chemical and metabolic stability, determination of the NCEs stability in plasma, determination of NCEs plasma protein binding.

Published 5 scientific papers, 20 SCI citations, H-index 2.

 

Publications:

Techlovská S, Chambers JN, Dvořáková M, Petralia RS, Wang YX, Hájková A, Nová A, Franková D, Prezeau L, Blahoš J. Metabotropic glutamate receptor 1 splice variants mGluR1a and mGluR1b combine in mGluR1a/b dimers in vivo. Neuropharmacology. 2014, 86, 329-36. ISSN: 0028-3908. IF (2013): 4.819. PMID: 25158311

Rulcova A, Krausova L, Smutny T, Vrzal R, Dvorak Z, Jover R, Pavek P. Glucocorticoid receptor regulates organic cation transporter 1 (OCT1, SLC22A1) expression via HNF4α upregulation in primary human hepatocytes. Pharmacol Rep. 2013, 65(5), 1322-35. ISSN: 1734-1140. IF (2012): 1,965. PMID: 24399729

Rulcova A, Prokopova I, Krausova L, Bitman M, Vrzal R, Dvorak Z, Blahos J, Pavek P. Stereoselective interactions of warfarin enantiomers with Pregnane X nuclear (PXR) receptor in gene regulation of major drug-metabolizing cytochrom P450 enzymes. J Thromb Haemost. 2010, 8(12), 2708-17. ISSN: 1538-7933. IF (2009): 6,069. PMID: 20735727

 

 

                         


Publications (Impact Factor Journals):

  • [4]
    SMUTNY, T., A. NOVÁ, M. DRECHSLEROVA, A. CARAZO, L. HYRSOVA, Z. HRUSKOVA, J. KUNEŠ, M. POUR, M. SPULAK a P. PAVEK. 2-(3-Methoxyphenyl)quinazoline Derivatives: A New Class of Direct Constitutive Androstane Receptor (CAR) Agonists. Journal of Medicinal Chemistry. 2016, 59(10), 4601-10. ISSN 0022-2623. IF: 6.259. PMID: 27145071
  • [3]
    PERLÍKOVÁ, P., G. RYLOVÁ, P. NAUŠ, T. ELBERT, E. TLOUŠŤOVÁ, A. BOURDERIOUX, L. SLAVĚTÍNSKÁ, K. MOTYKA, D. DOLEŽAL, P. ZNOJEK, A. NOVÁ, M. HARVANOVÁ, P. DŽUBÁK, M. ŠILLER, J. HLAVÁČ, M. HAJDÚCH a M. HOCEK. 7-(2-Thienyl)-7-deazaadenosine (AB61), a new potent nucleoside cytostatic with a complex mode of action. Molecular Cancer Therapeutics. 2016, 15(5), 922-937. ISSN 1535-7163 . IF: 5.764. PMID: 26819331
  • [2]
    STEJSKALOVA, L., A. RULCOVÁ, R. VRZAL, Z. DVORAK a P. PAVEK. Dexamethasone accelerates degradation of aryl hydrocarbon receptor (AHR) and suppresses CYP1A1 induction in placental JEG-3 cell line. Toxicology Letters. 2013, 223(2), 183-191. ISSN 0378-4274. IF: 3.355. PMID: 24091107
  • [1]
    STEJSKALOVA, L., R. VRZAL, A. RULCOVÁ, Z. DVORAK a P. PAVEK. Effects of glucocorticoids on cytochrome P450 1A1 (CYP1A1) expression in isolated human placental trophoblast. Journal of Applied Biomedicine. 2013, 11(3), 163-172. ISSN 1214-021X. IF: 1.775.

Books:

  • [1]
    NOVA, A. a P. PAVEK. Základy ADME a toxického hodnocení léčiv v preklinickém vývoji. 1. vyd. Olomouc: Univerzita Palackého v Olomouci, 2015. 64 s. ISBN: 978-80-244-4539-7.